The first hour of this podcast (https://peterattiamd.com/chrismasterjohn/) with Masterjohn discusses the subject in more detail than his LITE video. @ecstatichamster
We discuss:
- Chris’s background, falling in love with biochemistry, and decision to pursue research over medicine [7:45];
- Choline: what it is, why it is important, and how a deficiency can cause non-alcoholic fatty liver disease [11:45];
- NAFLD: increasing prevalence and potential causes [25:00];
- TMAO: Should we be worried about the TMAO content in choline and our foods? [39:15];
- Types of fatty acids: How they may predispose us to different types of illnesses [53:30];
- Why don’t we see low VLDL in patients with NAFLD? [59:45]
Thanks for the link. Chris talks about choline supplementation (or from food) here to as much as 1200 mg/day. He says an egg provides only about 150mg of it. I'm just not sure if this is a therapeutic dosage, but I imagine it is since taking this much choline in a regular day from food seems to be a lot considering you'd have to have an outsize portions in eggs, milk, and liver in a day.
He says choline is needed to transport trigylycerides out of the liver, and without it triglycerides accumulate in the liver.
I wonder if there's still other factors involved though. But didn't Ray Peat mention the role of PUFAs in cholesterol turning into cholesteryl esters? The polyunsaturated fatty acids that accumulate with age have been known for about 80 years to be the main source of this material. These fatty acids inhibit the synthesis of cholesterol and increase its conversion to cholesterol esters. pg. 5 Ray Peat Newsletter Nov 2018.
And Chris also has his say about cholesteryl esters in the liver, in this post by Mito:
Nov 2018: Dr. Peat Talks About Cholesterol Esters Causing Aging
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