Is It Safe To Take High Doses Of B Vitamins?

Discussion in 'Ask For Help or Advice' started by Connor888, Aug 1, 2020.

  1. Connor888

    Connor888 Member

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    [​IMG]

    I know some say you pee out what you don't use, but how much of a guarantee is that? Is it proven without any doubt ? My B12 is on the lower end and figured I may as well get a b complex in case im lacking in any other vitamins. Safe ?? I ask because as you can see by the pic the supplement I've seen has crazy high doses. Just strikes me as quite unnatural taking these vitamins in such high doses
    Thank you.e
     
  2. not_James_Bond

    not_James_Bond Member

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    Below is the one I use for B vitamins (and more);


    About £3.49 from the likes of Tesco, Holland & Barrett etcetera :): I find most of the B-complex tablets have enormous RDA doses, less is sometimes more IMO. Each pack contains 125 grams, so 25 days worth for £3.49.
    Basically with the amount per 5 gram serving you could take with each meal of the day IMO, oh and it tastes nice :hungry::handok:
    Also you might want to investigate Brewers Yeast too.
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  3. Jessie

    Jessie Member

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    I've seen several studies where really high doses of thiamine (up to 1,500mgs), niacinamide (up to 1,500mgs), and biotin (up to 300mgs) were used without incident or much drawback. These three in particular get used pretty rapidly by the body, so that may be why.

    Thiamine, if used in high doses for months at a time, could increase your potassium requirements. And niacinamide could increase your need for choline if used in high doses for months at a time. Generally though, there's many positive benefits to using B1, B3, and B7 in high doses for short intervals (1-4 weeks). Namely the combo can suppress FAO and reignite proper oxidative phosphorylation. It essentially has many of the same effects thyroid supplements have.

    Something like folate or B12 may be more harmful if used in high doses, since we use less of them on a daily basis.
     
  4. OP
    Connor888

    Connor888 Member

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    Great thank you that looks like a good product.
     
  5. OP
    Connor888

    Connor888 Member

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    If you remember where those studies were could you link them here please?
     
  6. Jessie

    Jessie Member

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    Yeah I can find some of them, many of which are on the forum. But I don't remember all of them. All these studies used high doses of these vitamins:

    Thiamine Is A Carbonic Anhydrase Inhibitor As Effective As Acetazolamide

    "The highest concentration of thiamine is required to inhibit hCA I and it is 380nM/L. This figure from a human study on the pharmacokinetics of thiamine shows that this concentration is achievable using a 1,500mg dose."

    Thiamine Reduces Both Lactate And Ammonia

    "The study was with humans and also included exercise, which makes thiamine even more interesting to athletes. The type of thiamine used was TTFD, which is the scientific name for allithiamine, and the dose was 10mg/kg. That would mean a total daily dose in the range of 600mg-900mg for most people."

    Niacinamide May Prevent Melanoma

    "About 2 years ago an Australian study hit frontpage news. It found that ingesting 1g niacinamide daily significantly reduced the risk of non-melanoma skin cancers."

    Niacinamide Can Treat Kidney Failure

    "This study shows that a HED dose of about 30mg/kg niacinamide for 4 days fully restored kidney function."

    Biotin As A Treatment For Multiple Sclerosis (MS)

    "This human study used 300mg daily dose of biotin in patients with MS and the results were so promising that 2 clinical trials are already underway."
     
  7. OP
    Connor888

    Connor888 Member

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    Thank you so much
     
  8. Frankdee20

    Frankdee20 Member

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    I’ve used this same product for many months off and on, but when I took two capsules, my anxiety increased....
     
  9. OP
    Connor888

    Connor888 Member

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    How did you find just the 1 capsule?
     
  10. David PS

    David PS Member

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  11. I like Mary Ruth's B complex drops. No b-1 in them though- they have made such a diff in my hair , nails, mood.
     
  12. SonOfEurope

    SonOfEurope Member

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    Has to be well over what the body would desire but then it might become a bit of a burden on the kidneys too.

    Still far less dangerous than OD on the Fat solubles.
     
  13. Energizer

    Energizer Member

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    Ray Peat Email Exchanges - Ray Peat Forum Wiki
     
  14. Jessie

    Jessie Member

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    Yeah, yeast tends to be the least adulterated multi vitamin on the market. Brewers yeast will work, I prefer nutritional yeast due to the cheesy flavor. I recommend a yeast that's non-fortified, so there's no excess iron. The one I get is by Sari Foods. Here's the nutrient composition, no B12 unfortunately, because B12 in yeast comes from the fortification process.
     

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  15. Energizer

    Energizer Member

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    Yeah, Brewers yeast doesn't have recipients, but might have a lot of estrogen.
     
  16. Jessie

    Jessie Member

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    That is true, trading one con for another I suppose. Few times a week is probably safe, I wouldn't recommend making it apart of the daily diet. Eggs, oysters, liver, and dairy can cover 99% of the basis.
     
  17. Hgreen56

    Hgreen56 Member

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    b-vitamines are water-soluble vitamins so you can never overdose them because you piss it out again if the body not using it.
    (the more yellow your urine is, the more money b-vitamines you peeing out)
     
  18. Ben.

    Ben. Member

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    Well i can only draw from my own experience taking high b-complex vitamins for 2 weeks daily. The urin is literally neon-yellow atleast at the initial pee after taking the vitamins.

    oddly enough after around 4-5 days my eyes changed in colour and intensity. From a greyish blue to a deep ocean blue like the actor in vikings as ragnar has. Sadly this effect only persisted for 2 days (coworkers were amazed tho).
    I didn't take any other supplements during that time i think. Perhaps Fishoil that had vitamin d and olive oil in it (yea i know better now...) and maybe i was experiementing with hericium mushroom capsules for my stomache issues.

    At the 6th or 7th day i started to get issues when taking it. Feeling nauseated or rather sick to my stomache... So i stopped taking it daily and only every second or third day. But this too eventually led to me feeling bad taking it.

    Conclusion for me was taking it 2-3 times a week should be fine and you get a fun colour while you pee, but anything in to high dosages as a supplement can be problematic long term.
     
  19. Hgreen56

    Hgreen56 Member

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    Take the b vitamins separately and find out which one gives you deep ocean blue eyes again.
    With a bit of luck you will find out which one makes you sick to.
     
  20. Ben.

    Ben. Member

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    Mhhhh i am not sure i understand you correctly. It was a experiment for my tinnitus a year ago.

    Taking them seperately in high dosages ... that sounds very expensive. Let's assume i take each B-Vitamin seperately i had in the complex which are 11. Then i use each seperately for 2 weeks. That means i need 22 weeks to go trough all.

    I actually think it was just to much in a to of a high dosage why i felt bad. Or do you guys take these high dosage vitamins on a regular basis without issues?
     
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