Interesting Properties Of The H2 Antagonist Famotidine

haidut

Member
Forum Supporter
Joined
Mar 18, 2013
Messages
19,795
Location
USA / Europe
Famotidine is unique among the H2 antagonists that it does not activate aromatase, cause osteoporosis, inhibit cytochrome p450 or suppress the immune system. I already posted some studies on the more interesting properties of famotidine. The studies in this thread are a more general summary of conditions famotidine has been shown to help.

1. Hepatoprotective
http://www.ncbi.nlm.nih.gov/pubmed/20070855

2. Promotes wound healing
http://www.ncbi.nlm.nih.gov/pubmed/17431284

3. Autism
http://www.ncbi.nlm.nih.gov/pubmed/11459079

4. Schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/10410190

5. Parkinson disease
http://www.ncbi.nlm.nih.gov/pubmed/8527008

6. Radiation protection
http://www.ncbi.nlm.nih.gov/pubmed/25634516
http://www.ncbi.nlm.nih.gov/pubmed/24619016
 

Philomath

Member
Joined
May 23, 2013
Messages
774
Age
54
Location
Chicagoland
Would Famotidine help mitigate the effects of typical doctor or dental x-rays ? Is it worth the effort to procure or would aspirin & VItE be more practical solutions?
 

aguilaroja

Member
Joined
Jul 24, 2013
Messages
850
Philomath said:
post 102928 Would Famotidine help mitigate the effects of typical doctor or dental x-rays ? Is it worth the effort to procure or would aspirin & VItE be more practical solutions?

First, famotidine (Pepcid) is over the counter (OTC) in some countries, including the U.S. and the U.K. and may be relatively accessible. It seems worth considering as one part of preventative measures for known x-ray risk.

As haidut described, famotidine may have many merits. However, famotidine is not as well absorbed as some pharmaceuticals, which may explain the radio-protective effects being described in the rectum (lower GI system).

It is a great and interesting question about what are the most helpful protective measures before known upcoming ionizing radiation. The list of supportive possibilities may be long. Aspirin and vitamin E are two worthy choices.

I will additionally mention two that Dr. Peat has discussed: progesterone and red wavelength light. Both might be used near in time to the radiation exposure. Practically, it is harder to carry around, say, a red light box, but getting promptly to a red light spectrum environment might be possible.

--
http://wiki.raypeatforum.com/index.php/ ... #Radiation
"[Does red light repair damage done just by U.V. light, or maybe also by X-rays?] By any irradiation, but it's most effective within the first hour. The harm from the radiation can be interrupted most effectively right away, before the changes have been amplified and integrated with the system."

http://raypeat.com/pdf/Radiation-and-Gr ... y-2011.pdf
"In 1973, Segaloff treated 3 groups of rats, (I) with estrogen and radiation (800 R of X-rays to half of the body), or (2) with estrogen. radiation and progesterone, or (3) with just radiation and progesterone. As in the earlier experiment, many tumors quickly appeared on the side of the body that received the radiation in most of the animals of group I, but in group 2 only one eighth as many tumors appeared in the animals that received progesterone. In the third group. no tumors appeared in the irradiated animals that received progesterone.-"

"This protective action of progesterone against radiation implies that X-rays have "estrogenic" effects on the body. This had previously been demonstrated very literally, when it was found that irradiating any part of the body of a female animal caused it to go into estrus, behaviorally as well as physiologically and biochemically."

http://en.wikipedia.org/wiki/Famotidine
"Famotidine suffers from poor bioavailability (50%), as it is poorly soluble in the low pH of the stomach. When used in combination with antacids, it promotes local delivery of these drugs to the receptor of the parietal cell wall. Therefore, researchers are developing innovative formulations of tablets, such as gastroretentive drug delivery systems."

http://raypeat.com/articles/aging/aspir ... ncer.shtml
"Since the 1970s, aspirin has been thought of as an inhibitor of prostaglandin synthesis, but that is only part of its effect. Sometimes its effect is the opposite of the effects of other prostaglandin inhibitors.
It protects against the harmful effects of estrogen, prolactin, serotonin, cortisol, histamine, and radiation (u.v., x-rays, gamma rays)."

http://raypeat.com/articles/articles/fa ... ion3.shtml
"PUFA and x-rays have many biological effects in common. They are immunosuppressive, but they produce their own inflammatory reactions, starting with increased permeability of capillaries, disturbed coagulation and proteolysis, and producing fibrosis and tumefaction or tissue atrophy. This isn't just a coincidence, since ionizing radiation attacks the highly unstable polyunsaturated molecules, simply accelerating processes that ordinarily happen more slowly as a result of stress and aging."
 
Last edited by a moderator:

GAF

Member
Joined
Dec 28, 2014
Messages
789
Age
67
Location
Dallas Texas
Famotidine - Wikipedia, the free encyclopedia
"Famotidine suffers from poor bioavailability (50%), as it is poorly soluble in the low pH of the stomach. When used in combination with antacids, it promotes local delivery of these drugs to the receptor of the parietal cell wall. Therefore, researchers are developing innovative formulations of tablets, such as gastroretentive drug delivery systems."

I take one or two of these per day. Does "when used in combination with antacids" above mean that I should chew a Tums with it or not? Or, is there some other delivery system that would make it more effective? Smashing the little pill into powder? Thanks for your assistance.
 
Joined
Nov 21, 2015
Messages
10,501
I take one or two of these per day. Does "when used in combination with antacids" above mean that I should chew a Tums with it or not? Or, is there some other delivery system that would make it more effective? Smashing the little pill into powder? Thanks for your assistance.

why are you taking it?

It seems antacids would compound the stomach acid reducing, which may not be a great idea.

I think the reason famotidine works in stomach problems is due to effects on mucosa, not acid reduction.
 

GAF

Member
Joined
Dec 28, 2014
Messages
789
Age
67
Location
Dallas Texas
Primarily acid reflux or more likely LPR. What mucosa does it impact? I have throat mucus issue.
 

Texon

Member
Joined
Nov 28, 2016
Messages
668

7. Guess antidote for serotonin syndrome is something else positive about Famotidine unless already covered elsewhere in this forum.

https://www.google.com/url?sa=t&sou...H_8Ol-HHSq-668Utw&sig2=l7rX-yi8Dlr_fZopFVghgw
 
OP
haidut

haidut

Member
Forum Supporter
Joined
Mar 18, 2013
Messages
19,795
Location
USA / Europe
7. Guess antidote for serotonin syndrome is something else positive about Famotidine unless already covered elsewhere in this forum.

https://www.google.com/url?sa=t&sou...H_8Ol-HHSq-668Utw&sig2=l7rX-yi8Dlr_fZopFVghgw

Thanks for this link! Here is the actual study with the relevant quote.
Famotidine-induced reversal of meperidine-related serotonin syndrome: a case report
"...Serotonin syndrome is an unexpected fatal adverse event related to serotonergic medication. This case report is the first report describing the possible treatment effect of famotidine on serotonin syndrome. Furthermore, this is the first case report of serotonin syndrome induced by meperidine alone in a patient with no previous history suggesting a susceptibility to serotonin syndrome. A 70-year-old male with no recent history of serotonergic drug use presented with severe serotonin syndrome following ureteroscopy, possibly due to postoperative meperidine administration. The patient's symptoms included hypertension, tachycardia, tachypnea, hyperthermia, myoclonus, diaphoresis, retching, nausea, agitation, and semicoma mentality with no pupillary light reflex. Symptoms began to subside immediately after the administration of intravenous famotidine for prevention of aspiration pneumonia, with mental and neurological symptoms showing improvement initially, followed by autonomic symptoms. This case report suggests that the histamine type 2 receptor antagonist famotidine may be an effective emergency treatment for serotonin syndrome."

Btw, inside that study they reference another one showing that H2 antagonism in the gut with other drugs similar to famotidine reduces serotonin levels. So, H1 antagonists, which are known to antagonize H2 in higher doses, should also reduce serotonin levels. Thus, drugs like cyproheptadine and Benadryl may be not only serotonin antagonists but serotonin synthesis inhibitors as well. A double-benefit for those already highly beneficial drugs.
Effects of eight-week treatment with histamine H2-antagonists or an antacid on plasma levels of histamine and serotonin in duodenal ulcer patients. - PubMed - NCBI
"...The effects of 8-week treatment with oral histamine H2-antagonists (ranitidine or cimetidine) or an antacid on plasma levels of histamine and serotonin were studied in duodenal ulcer patients. Histamine H2-antagonists significantly elevated plasma histamine levels, however, they markedly decreased serotonin concentrations by the 4th week of treatment. Antacid treatment similarly increased histamine levels without significantly affecting blood serotonin. It is concluded that changes in intragastric or intraduodenal acidity affect histamine release, as reflected by increased blood levels; serotonin secretion could be influenced by blocking histamine H2-receptors, possibly those located mainly in the gastrointestinal tract."
 

YourUniverse

Member
Joined
Nov 14, 2017
Messages
2,034
Location
your mind, rent free
Famotidine is an OTC carbonic anhydrase inhibitor available in Canada and I thought it would be a good substitute for acetazolamide that Ray has recommended many times. Problem is that, it comes as Pepcid AC, which has awful excipients like titanium dioxide. Does pure famotidine exist..?
 
Joined
Oct 13, 2019
Messages
140
I have the same question. If anyone knows a source of famotidine without horrible ingredients, please let us know.
I’m not sure there is one. Haidut was interested in creating a famotadine supplement a few years ago but I haven’t seen any updates on that
 
EMF Mitigation - Flush Niacin - Big 5 Minerals

Similar threads

Back
Top Bottom