Famotidine Is A Powerful Anti-serotonin Drug, Can Even Treat Serotonin Syndrome

haidut

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I wanted to make this as a separate thread, given how important anti-serotonin chemicals for metabolism and how few of them are available OTC. It looks like our old friend famotidine is a powerful inhibitor of serotonin synthesis in the GI tract, and the mechanism of action is the H2 antagonism as other H2 antagonists of the same class also appear to lower serotonin.
The only drug known to stop a serotonin syndrome already in progress is cyproheptadine. Metergoline has also been used in some cases but it is much rarer drug than cyproheptadine so alternatives are definitely needed. Now it seems that 10mg - 20mg famotidine is a very viable alternative, and an OTC at that too.
If famotidine is indeed an inhibitor of serotonin synthesis then this may explain its effects on improving insulin sensitivity, treating schizophrenia, preventing GI fibrosis, improving glycogen storage, etc. All of these pathologies involve excess serotonin to some degree.
Thanks to user @Texon for the reference!

Interesting Properties Of The H2 Antagonist Famotidine

Famotidine-induced reversal of meperidine-related serotonin syndrome: a case report
"...Serotonin syndrome is an unexpected fatal adverse event related to serotonergic medication. This case report is the first report describing the possible treatment effect of famotidine on serotonin syndrome. Furthermore, this is the first case report of serotonin syndrome induced by meperidine alone in a patient with no previous history suggesting a susceptibility to serotonin syndrome. A 70-year-old male with no recent history of serotonergic drug use presented with severe serotonin syndrome following ureteroscopy, possibly due to postoperative meperidine administration. The patient's symptoms included hypertension, tachycardia, tachypnea, hyperthermia, myoclonus, diaphoresis, retching, nausea, agitation, and semicoma mentality with no pupillary light reflex. Symptoms began to subside immediately after the administration of intravenous famotidine for prevention of aspiration pneumonia, with mental and neurological symptoms showing improvement initially, followed by autonomic symptoms. This case report suggests that the histamine type 2 receptor antagonist famotidine may be an effective emergency treatment for serotonin syndrome."

Btw, inside that study they reference another one showing that H2 antagonism in the gut with other drugs similar to famotidine reduces serotonin levels. So, H1 antagonists, which are known to antagonize H2 in higher doses, should also reduce serotonin levels. Thus, drugs like cyproheptadine and Benadryl may be not only serotonin antagonists but serotonin synthesis inhibitors as well. A double-benefit for those already highly beneficial drugs.
Effects of eight-week treatment with histamine H2-antagonists or an antacid on plasma levels of histamine and serotonin in duodenal ulcer patients. - PubMed - NCBI
"...The effects of 8-week treatment with oral histamine H2-antagonists (ranitidine or cimetidine) or an antacid on plasma levels of histamine and serotonin were studied in duodenal ulcer patients. Histamine H2-antagonists significantly elevated plasma histamine levels, however, they markedly decreased serotonin concentrations by the 4th week of treatment. Antacid treatment similarly increased histamine levels without significantly affecting blood serotonin. It is concluded that changes in intragastric or intraduodenal acidity affect histamine release, as reflected by increased blood levels; serotonin secretion could be influenced by blocking histamine H2-receptors, possibly those located mainly in the gastrointestinal tract."


Oh, almost forgot. Inhibition of gut serotonin levels by administering TPH inhibitors is so far successful in clinical trials to treat obesity, diabetes, and IBS. Maybe famotidine can provide the same results at a fraction of the cost and with an extensive safety track record?? These new drugs have barely been tested, so we know nothing about their long term side effects.

Diabetes/Obesity:
Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity
Peripheral Serotonin: a New Player in Systemic Energy Homeostasis
Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation : Scientific Reports

IBS:
The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome. - PubMed - NCBI
LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. - PubMed - NCBI
LX-1031, a Tryptophan 5-hydroxylase Inhibitor, and Its Potential in Chronic Diarrhea Associated with Increased Serotonin
 
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encerent

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I really hope the FDA doesn't find out about these extra effects of famotidine.
 

Regina

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I wanted to make this as a separate thread, given how important anti-serotonin chemicals for metabolism and how few of them are available OTC. It looks like our old friend famotidine is a powerful inhibitor of serotonin synthesis in the GI tract, and the mechanism of action is the H2 antagonism as other H2 antagonists of the same class also appear to lower serotonin.
The only drug known to stop a serotonin syndrome already in progress is cyproheptadine. Metergoline has also been used in some cases but it is much rarer drug than cyproheptadine so alternatives are definitely needed. Now it seems that 10mg - 20mg famotidine is a very viable alternative, and an OTC at that too.
If famotidine is indeed an inhibitor of serotonin synthesis then this may explain its effects on improving insulin sensitivity, treating schizophrenia, preventing GI fibrosis, improving glycogen storage, etc. All of these pathologies involve excess serotonin to some degree.

Interesting Properties Of The H2 Antagonist Famotidine
It would be great if you made one so we don't have to take the heavily junked up commercial version.

Is it safe to take famotidine long term?
 

DaveFoster

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All the more reason to release an IdeaLabsDC UlcerBan supplement!
 

TubZy

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It would be great if you made one so we don't have to take the heavily junked up commercial version.

Is it safe to take famotidine long term?

X2, the OTC ones are junk. They don't sell the liquid gel ones anymore either.
 

TubZy

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Even if it has junk in it, still better than nothing if it suits your body.

Well given it specifically is beneficial to the gut and ulcers, I would prefer not to take famo without titanium dioxide and stearates and silica and there is much more than that in it- that is rough on the digestive tract alone especially long term and worst excipients in the peat land
 
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haidut

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OK, I will see what I can do. It is OTC in the USA, so it should be fine to sell as a R&D product.
 

encerent

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Well given it specifically is beneficial to the gut and ulcers, I would prefer not to take famo without titanium dioxide and stearates and silica and there is much more than that in it- that is rough on the digestive tract alone especially long term and worst excipients in the peat land
There are dozens of brands. There really isn't one that is clean?
 

TubZy

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There are dozens of brands. There really isn't one that is clean?

Nope. Here is just one example of how much ***t is in it. This is the least of them, I could find too, this is for one 10mg tablet so if you are planning to do 20mg, 30mg etc per day this crap adds up.
 
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