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inhibitor

  1. haidut

    Niacinamide may treat lymphoma

    A very interesting study and a "synchronicity" event as well, considering the recent in-vivo experiments I conducted with a combination of vitamin B1 and vitamin B3 (niacinamide) in a mouse xenograft model of human mantle-cell lymphoma. In that experiment of mine, HED of 15mg/kg B1 and 30mg/kg...
    • haidut
    • Thread
    • hdac inhibitor lymphoma niacinamide sirt3 sirtuin vitamin b3
    • Replies: 2
    • Forum: Scientific Studies
  2. haidut

    Inhibiting Fatty Acid Synthesis (FAS) Dramatically Improves Sepsis Survival Rate

    Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...
    • haidut
    • Thread
    • endotoxin energy fao fas fasn fatty acid oxidation fatty acid synthase infection inhibit inhibitor randle cycle sepsis tlr tlr4
    • Replies: 6
    • Forum: Scientific Studies
  3. haidut

    Artificially Lowering Blood Glucose May Cause Fatal Flesh-eating Infection

    ...targeting the genitals, of all places. The warning FDA issued is for drugs used to artificially lower blood glucose levels in patients with type II diabetes. The list includes blockbuster drugs like Invokana, Jardiance, etc. The drugs works by forcing the kidneys to excrete glucose extracted...
    • haidut
    • Thread
    • bacteria blood glucose diabetes fatal fatal infection fda inhibitor invokana jardiance sglt2 side effect warning
    • Replies: 13
    • Forum: Scientific Studies
  4. haidut

    Fatty Acid Oxidation (FAO) Makes Cancer Therapy-resistant, Niacinamide May Help

    Yet another study that shows FAO playing a crucial role in cancer progression. As many forum users know, anti-angiogenic therapies are one of the cornerstones of current cancer treatments. This therapy typically uses the so-called VEGF inhibitors to block the formation of new blood vessels in...
    • haidut
    • Thread
    • angiogenesis cancer cpt1 fatty acid oxidation hypoxia inhibitor lipolysis metastasis mildronate niacinamide progression tumor vegf
    • Replies: 0
    • Forum: Scientific Studies
  5. haidut

    Inosine As A Powerful Inhibitor Of Serotonin And Cortisol Synthesis

    As many of you know, I have been reading older Russian studies on many of the substances Peat talks about. He mentioned inosine in one of is articles, but only in relation to improving immunity and preventing dementia. The problem of Alzheimer's disease as a clue to immortality Part 1...
    • haidut
    • Thread
    • hypoxanthine inhibitor inosine mao-a mao-b serotonin synthesis
    • Replies: 38
    • Forum: Scientific Studies
  6. haidut

    Plain (unmodified) Adamantane Is A Powerful Inhibitor Of NO Synthesis

    Many people on the forum are familiar with the beneficial properties of adamantane and its derivatives. However, most of the research conducted on the beneficial effects of these chemicals has been with adamantane derivatives such as amantadine, memantine, rimantadine, bromantane, etc. When we...
    • haidut
    • Thread
    • adamantane endotoxin inhibitor inos lps nitric oxide no synthesis
    • Replies: 11
    • Forum: Scientific Studies
  7. haidut

    Yet Another Study Calls For Inhibiting Fat Oxidation As A Treatment For Cancer

    I have posted a number of threads on the role of fatty acid oxidation (FAO) and fatty acid synthase (FAS) in cancer growth and progression. Inhibiting Lipolysis May Treat / Cure Cancer For more than 100 years FAO and FAS were thought of pathways irrelevant for cancer and also as ones that are...
    • haidut
    • Thread
    • cancer cure fatty acid oxidation fatty acid synthesis inhibit inhibitor therapeutic treatment
    • Replies: 17
    • Forum: Scientific Studies
  8. haidut

    Palmitic Acid (palmitate) Dramatically Inhibits Liver Cancer Progression

    I posted a thread yesterday showing that palmitic acid is a strong inhibitor of fatty acid oxidation, perhaps more effective than established drugs like Mildronate. Palmitic acid also seems to be able to double oxidative metabolism when used in relatively low doses. Palmitic Acid (palmitate) Is...
    • haidut
    • Thread
    • fatty acid oxidation fatty acid synthesis hcc hepatoma inhibitor liver cancer palmitate palmitic acid
    • Replies: 15
    • Forum: Scientific Studies
  9. haidut

    PUFA And MUFA Are Strong Inhibitors Of 5-AR, Saturated Fatty Acids Are Not

    I have posted quite a few studies showing the effects of various fatty acids on estrogen, androgen and glucocorticoid synthesis. This study shows that both PUFA and MUFA are strong inhbitors of 5-AR, with PUFA being the more potent inhibitors and inhibition potency being strongly dependent on...
    • haidut
    • Thread
    • 5-alpha reductase androgens dht inhibition inhibitor mufa prostaglandins pufa
    • Replies: 54
    • Forum: Scientific Studies
  10. haidut

    Alzheimer Disease (AD) May Be Simply Diabetes Of The Brain

    I touched upon this topic in one of the Danny Roddy shows we did last year but the evidence since then has continues to accumulate that AD is entirely a metabolic disorders, basically identical to diabetes but focusing on the brain. A recent study found that delirium, an acute form of...
    • haidut
    • Thread
    • ad alzheimer's brain dementia dhea diabetes glucose inhibitor insulin resistance memantine potassium channel
    • Replies: 13
    • Forum: Scientific Studies
  11. haidut

    Famotidine Is A Powerful Anti-serotonin Drug, Can Even Treat Serotonin Syndrome

    I wanted to make this as a separate thread, given how important anti-serotonin chemicals for metabolism and how few of them are available OTC. It looks like our old friend famotidine is a powerful inhibitor of serotonin synthesis in the GI tract, and the mechanism of action is the H2 antagonism...
    • haidut
    • Thread
    • anti-histamine famotidine inhibit inhibitor prevent serotonin serotonin syndrome treatment
    • Replies: 131
    • Forum: Scientific Studies
  12. haidut

    Pregnenolone Is A Potent Aldosterone Antagonist (antimineralocorticoid)

    Ray has written a number of articles on the hypertension, heart and kidney failure, eclampsia, and CVD in which he describes the central role of aldosterone in the pathogenesis of these conditions. Aldosterone antagonists (antimineralocorticoids - e.g. spironolactone, itself a pregnenolone...
    • haidut
    • Thread
    • aldosterone antagonist inhibitor mineralocorticoid pregnenolone
    • Replies: 10
    • Forum: Scientific Studies
  13. haidut

    Blocking PUFA Metabolism May Reverse Alzheimer Disease (AD)

    I posted a few studied showing PUFA and its metabolites are strongly involved in AD and brain aging in general. Increased Pufa Oxidation May Be Biomarker For Alzheimers Blocking Inflammation From PUFA Reverses Brain Aging The second link above discussed specifically the inhibition of the...
    • haidut
    • Thread
    • alox15 alzheimer's brain inflammation inhibitor leukotrienes lipoxygenase lox
    • Replies: 11
    • Forum: Scientific Studies
  14. haidut

    Dietary Fat And Its Oxidation Drives Cancer Metastasis

    Yet another study that discover cancer cells love for fat. As I posted in a few other threads, cancer cells actually need fat (preferably PUFA) for metastasis and survival, and use sugar for ATP generation. Achilles Heel Of Cancer Found - Its Addiction To Fat Cancer Cells Addicted To Fat And Use...
    • haidut
    • Thread
    • cancer cd36 cell fat inhibitor lipid metastasis preference
    • Replies: 31
    • Forum: Scientific Studies
  15. haidut

    Natural Progesterone Treats Breast Cancer, Synthetic Progestins Promote It

    I think as early as the 1980s Ray was already writing about the beneficial effects of progesterone for breast cancer and the negative effects of synthetic progestins (most of which are actually 19-nortestosterone derivatives). The pharma industry published fraudulent studies with which to...
    • haidut
    • Thread
    • breast cancer inhibitor megace progesterone progestin synthetic treatment
    • Replies: 14
    • Forum: Scientific Studies
  16. haidut

    5α-Dihydroprogesterone (5α-DHP) Is More Effective Than Progesterone In Lowering Prolactin

    Similar to the stud on estrogen receptor decrease, this study shows that the saturated progesterone metabolite 5α-dihydroprogesterone (5α-DHP) is more effective than progesterone at inhibiting prolactin release from the pituitary. Just as in the estrogen study, the effective doses of 5α-DHP were...
    • haidut
    • Thread
    • 5α-dhp 5α-dihydroprogesterone estrogen inhibitor pituitary progesterone prolactin
    • Replies: 29
    • Forum: Scientific Studies
  17. haidut

    Aspirin Is A Janus Kinase (JK) Inhibitor

    The so-called JK inhibitor drugs are all the rage right now for a number of chronic inflammatory conditions including IBD, RA, Lupus, MS, cancer and Alzheimer. This study found that aspirin (salicylic acid) is a potent JK inhibitor and as such relevant for all the conditions mentioned above. Not...
    • haidut
    • Thread
    • ampk aspirin cancer inflammation inhibition inhibitor jak janus jk kinase
    • Replies: 1
    • Forum: Scientific Studies
  18. haidut

    Low-dose DHEA Inhibits Aromatase By 35% And Endotoxin Blocks That Effect

    I found this study while researching the conversion of DHEA into steroids with immunomodulating effects. As you can see (attached picture), a DHEA concentration of 1µM inhibited aromatase activity by about 35%. This concentration of DHEA can be easily achieved with 3mg - 5mg topical DHEA in...
  19. haidut

    Vitamin D Inhibits The Deactivation Of Androgens

    Vitamin D is one of the most versatile substances in Peat world. It is actually a steroid and not a true vitamin, and as a steroid it is expected to have effects on other steroids. Its role in opposing estrogen, together with the other fat-soluble vitamins, is well-known. Now, this study shows...
    • haidut
    • Thread
    • androgen receptor androgens androsterone calcitriol deactivation dht glucuronidation inhibitor study vitamin d
    • Replies: 12
    • Forum: Scientific Studies
  20. haidut

    PPI Drugs (anti GERD) Powerfully Inhibit Steroidogenesis

    I have always been suspicious of PPI drugs. There are many reasons for it, including the falsified clinical trial data to conceal increased risk of gastric cancer, the idiotic premise that gastric acid increases with age, the kidney failure side effects, and the calcium/magnesium depletion being...
    • haidut
    • Thread
    • cholesterol gerd inhibition inhibitor ppi pregnenolone side cleavage side cleavage enzyme steroidogenesis steroids
    • Replies: 3
    • Forum: Scientific Studies
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