1. charlie

    Two-Year Toxicity Study of Doxylamine Succinate in B6C3F1 Mice

    Abstract Doxylamine succinate, a commonly used antihistamine, was administered as an admixture in the feed to groups of male and female B6C3F1 mice at dosage levels of 0,190,375, and 750 parts per million (ppm) (based on free amine) for 65 weeks (12 per group) or 2 years (48 per group). Survival...
  2. md_a

    Ray Peat Interview Dr. Ray Peat, Ph.D – Your Health Questions Answered – February 21, 2022
  3. T

    Antihistamines Raise Prolactin?

    Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis H1-antihistamine is generally a well-tolerated and safe drug. However, in resemblance with all other drugs, H1-antihistamines can also prompt adverse drug reactions (ADRs). We recently encountered the...
  4. P

    Positive Effect Of H1 Antihistamines On Bone Density

    Anti-histamine Therapy and Bone Mineral Density: Analysis in a Population-Based U.S. Sample Background Histamine may play an important role in bone turnover. The data regarding histamine receptor antagonists (H1RA, H2RA) and bone mineral density in humans are sparse. We examined bone mineral...
  5. haidut

    Ketotifen May Treat Hashimoto's

    I am posting this study for those people who need an alternative to thyroid hormone treatment. This is a human study, so it is even more relevant for people with Hashimoto's. Given the main effects of ketotifen as a histamine and leukotriene antagonist, as well as some serotonin antagonism it...
  6. haidut

    Ketotifen Prevents Skin Aging/wrinkles Due To UV Light

    Meet your new beauty ingredient - ketotifen. UV light exposure is one of the main triggers of visible signs of skin aging and contributes to lipofuscin formation as well. It looks like ketotifen may be able to prevent that damage and given its leukotriene and histamine antagonism it may be a...
  7. haidut

    Famotidine Is A Powerful Anti-serotonin Drug, Can Even Treat Serotonin Syndrome

    I wanted to make this as a separate thread, given how important anti-serotonin chemicals for metabolism and how few of them are available OTC. It looks like our old friend famotidine is a powerful inhibitor of serotonin synthesis in the GI tract, and the mechanism of action is the H2 antagonism...
  8. schultz

    Analgesic Effects Of 1st Gen. Anti-histamines

    I wanted to share this study with you all because I found it most interesting! I believe there are already studies showing the analgesic effects of 1st gen AH's, but I thought this paper was concise and summarised the research to date. The paper mentions that this probably would have been...
  9. HealthisWealth

    Clemastine (marshtine)

    Any experience about this antihistamine? Its available in my country. I really want to try cyproheptadine but not available. I have read in haidut post and in layman's term what is FIASMA?
  10. haidut

    OTC Anti-histamines With Anti-serotonin Action

    Given that some people cannot get access to or do not tolerate well drugs like cyproheptadine or mirtazapine, this study offers some possible OTC alternatives for blocking serotonin. As you can see, Benadryl is also in the list but its anti-serotonin activity is much weaker compared to other...
  11. DaveFoster

    Peat Battle Rumble: The Ultimate Anti-Histamine Wonder Drug

    So, let's talk anti-histamines and anti-cholinergic drugs. Obviously, they reduce the short-term memory capabilities of the individual, but as purported by haidut, such executive capacities are enhanced through the actions of estrogen, for example, so they are a short-term gain at the expense...
  12. managing

    Ketotifen (Zaditen)

    Anybody know anything about?
  13. haidut

    Vitamin B6 Is Anti-histamine And Potential Asthma Treatment

    The study was with pyridoxine hydrochloride (the cheap version of B6 available everywhere), and the dosage for children was 200mg. The authors also state that niacinamide has similar/same effects.