Dopaminergic Drugs Treat Ulcers Better Than Acid-blockers

haidut

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Many people on the forum are former or current users of PPI drugs or H2 antagonists. Most of these drugs (ith the possible exception of famotidine) have bad side effects that can persist years after a person stops taking the drugs.
This study says that there is no need for taking those drugs. Dopaminergic drugs like bromocriptine are not only just as effective at healing ulcers, the relapse rate from dopaminergic drugs is much lower than the one for acid-blocking drugs. So, it looks like it may be better to try bromocriptine or lisuride for GI issues, epecially considering their agtagonism of serotonin, which should help GI recovery even more.
I don't know if dopaminergic drugs can help conditions like GERD but it sounds plausible that they would, assuming GERD is caused by serotonin weakening the esophageal sphincter.

http://www.ncbi.nlm.nih.gov/pubmed/2070703

"...The present study investigated both the healing rate (after four weeks) and the relapse rate (during six months) following treatment with the dopamine-like drugs bromocriptine (2.5 mg twice daily), amantadine (100 mg nocte), or with the H2 blockers cimetidine (800 mg nocte), and famotidine (40 mg nocte) in 124 patients with endoscopically proven duodenal ulcer (DU). The ulcer was completely healed in 27 (amantadine), 26 (bromocriptine), 23 (cimetidine), and in 24 (famotidine) patients. Relapse was noted in 34.7% (cimetidine) and 25% (famotidine) versus 11.7% (amantadine) and 7.7% (bromocriptine) DU patients. No significant difference was found in initial healing rates. However, the relapse rate in the cimetidine-treated group was significantly higher than in all the other test groups. Additional comparisons between all the treatment categories showed a significantly lower relapse rate with the dopamine-like agents. These important new results indicate that dopamine-like compounds are equally effective as H2 blockers in inducing DU healing and may offer a promising advantage over H2 blockers concerning their efficacy in preventing ulcer relapse in DU patients."
 

Mat_Eire

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Oct 18, 2016
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Many people on the forum are former or current users of PPI drugs or H2 antagonists. Most of these drugs (ith the possible exception of famotidine) have bad side effects that can persist years after a person stops taking the drugs.
This study says that there is no need for taking those drugs. Dopaminergic drugs like bromocriptine are not only just as effective at healing ulcers, the relapse rate from dopaminergic drugs is much lower than the one for acid-blocking drugs. So, it looks like it may be better to try bromocriptine or lisuride for GI issues, epecially considering their agtagonism of serotonin, which should help GI recovery even more.
I don't know if dopaminergic drugs can help conditions like GERD but it sounds plausible that they would, assuming GERD is caused by serotonin weakening the esophageal sphincter.

Dopamine agonists prevent duodenal ulcer relapse. A comparative study with famotidine and cimetidine. - PubMed - NCBI

"...The present study investigated both the healing rate (after four weeks) and the relapse rate (during six months) following treatment with the dopamine-like drugs bromocriptine (2.5 mg twice daily), amantadine (100 mg nocte), or with the H2 blockers cimetidine (800 mg nocte), and famotidine (40 mg nocte) in 124 patients with endoscopically proven duodenal ulcer (DU). The ulcer was completely healed in 27 (amantadine), 26 (bromocriptine), 23 (cimetidine), and in 24 (famotidine) patients. Relapse was noted in 34.7% (cimetidine) and 25% (famotidine) versus 11.7% (amantadine) and 7.7% (bromocriptine) DU patients. No significant difference was found in initial healing rates. However, the relapse rate in the cimetidine-treated group was significantly higher than in all the other test groups. Additional comparisons between all the treatment categories showed a significantly lower relapse rate with the dopamine-like agents. These important new results indicate that dopamine-like compounds are equally effective as H2 blockers in inducing DU healing and may offer a promising advantage over H2 blockers concerning their efficacy in preventing ulcer relapse in DU patients."

@haidut Do u think that 2,5 mg bromcriptine long term would be safe long term?. It does wonders for my mucosa but I have heard it can affect heart and have other dangerous sides.
 

cedric

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GERD is connected with high NO.
Melatonin, cobalamin, betaine are helpful.
Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omepr... - PubMed - NCBI

J Pineal Res. 2006 Oct;41(3):195-200.
Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole.
Pereira Rde S1.
Author information
1
Depto. de Farmácia-Universidade Estadual da Paraíba, Av das Baraúnas, 351/Campus Universitário, Bodocongó/Campina Grande-PB-Brazil-CEP 58109-753, Brazil. [email protected]
Abstract
The prevalence of gastroesophageal reflux disease (GERD) is increasing. GERD is a chronic disease and its treatment is problematic. It may present with various symptoms including heartburn, regurgitation, dysphagia, coughing, hoarseness or chest pain. The aim of this study was to investigate if a dietary supplementation containing: melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine would help patients with GERD, and to compare the preparation with 20 mg omeprazole. Melatonin has known inhibitory activities on gastric acid secretion and nitric oxide biosynthesis. Nitric oxide has an important role in the transient lower esophageal sphincter relaxation (TLESR), which is a major mechanism of reflux in patients with GERD. Others biocompounds of the formula display anti-inflammatory and analgesic effects. A single blind randomized study was performed in which 176 patients underwent treatment using the supplement cited above (group A) and 175 received treatment of 20 mg omeprazole (group B). Symptoms were recorded in a diary and changes in severity of symptoms noted. All patients of the group A (100%) reported a complete regression of symptoms after 40 days of treatment. On the other hand, 115 subjects (65.7%) of the omeprazole reported regression of symptoms in the same period. There was statiscally significant difference between the groups (P < 0.05). This formulation promotes regression of GERD symptoms with no significant side effects.
 
EMF Mitigation - Flush Niacin - Big 5 Minerals

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