Cyproheptadine Lowers TSH

[haidut]

Given that cyproheptadine also increases plasma levels of T4, it may be an option for hypothyroid people who cannot tolerate thyroid hormone or do not ant to take it.

http://www.ncbi.nlm.nih.gov/pubmed/10437145

"...RESULTS: Cyp 2.3 mg.kg-1 ig for 10 d decreased serum thyroid stimulating hormone (TSH) from control groups (5.3 +/- 0.9) to (4.2 +/- 0.9) mU.L-1 and insulin levels from (64 +/- 8) to (50 +/- 9) kIU.L-1 (P < 0.05 and 0.01). Cyp 4.6 mg.kg-1 decreased serum TSH (3.8 +/- 0.5) mU.L-1, T3 (1.2 +/- 0.2) mmol.L-1, T4 (62 +/- 7) mmol.L-1, and insulin levels (42 +/- 8) kIU.L-1 decreased (P < 0.05 or 0.01). The retrograde changes of ultrastructure of pituitary TSH cells and pancreatic beta cells."

 

[m_arch]

When the question because "what doesn't cyproheptadine do?"

..anything bad :-P

 

[misery guts]

Haidut, do you suspect this to be a function of its effects on serotonin, or some other route?

 

[passivity]

nice!

 

[Waynish]

I bet very few of these cypro studies use transdermal cypro - so I wonder how different the effects are. I'll have to try searching for some cypro pills, or get idealab's cypro into capsules.

 

[InChristAlone]

There is one side effect to be aware of. Due to its antimuscarinic effects it can lead to dry mucous membranes. After 8 months I developed a bump on my eye that isn't going away. Other than that it's really great!

 

[tomisonbottom]

Given that cyproheptadine also increases plasma levels of T4, it may be an option for hypothyroid people who cannot tolerate thyroid hormone or do not ant to take it.

Inhibitory effects of cyproheptadine on pituitary-thyroid axis and pancreatic beta cells in rats. - PubMed - NCBI

"...RESULTS: Cyp 2.3 mg.kg-1 ig for 10 d decreased serum thyroid stimulating hormone (TSH) from control groups (5.3 +/- 0.9) to (4.2 +/- 0.9) mU.L-1 and insulin levels from (64 +/- 8) to (50 +/- 9) kIU.L-1 (P < 0.05 and 0.01). Cyp 4.6 mg.kg-1 decreased serum TSH (3.8 +/- 0.5) mU.L-1, T3 (1.2 +/- 0.2) mmol.L-1, T4 (62 +/- 7) mmol.L-1, and insulin levels (42 +/- 8) kIU.L-1 decreased (P < 0.05 or 0.01). The retrograde changes of ultrastructure of pituitary TSH cells and pancreatic beta cells."

What is the HED for that?

 

[haidut]

What is the HED for that?

Around 0.3mg/kg for a human.

 

[tomisonbottom]

Around 0.3mg/kg for a human.

Oh wow, ok, thanks