GABA decreases flouride inuced hypothyroidism; more effective than thyroid hormone

Mauritio

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This study shows that GABA increases thyroid hormones that were downregulsted from fluoride ingestion in mice .
This shows what a pro metabolic and protective effect GABA has on the body .
So people drinking high fluoride water might want to stack up on GABA for thyroid protection .

"Subacute injection of sodium fluoride (NaF) decreased blood T4, T3 and thyroid hormone-binding globulin (TBG) levels to 33.98 μg/l, 3 2.8 ng/ml and 11.67 ng/ml, respectively. In addition, fluoride intoxication induced structural abnormalities in thyroid follicles. Our results showed that treatment of fluoride-exposed mice with GABA appreciably decreased metabolic toxicity induced by fluoride and restored the microstructural and ultrastructural organisation of the thyroid gland towards normalcy. Compared with the negative control group, GABA treatment groups showed significantly upregulated T4, T3 and TBG levels (42.34 μg/l, 6.54 ng/ml and 18.78 ng/ml, respectively; P < 0.05), properly increased TSH level and apoptosis inhibition in thyroid follicular epithelial cells."

"Treatment of mice with high concentration of GABA countered the fluoride-induced
alteration of T3 level by 17.7% (P > 0.05), indicating that GABA exerted a better protective
effect than thyroid tablet against fluoride-induced decrease in blood T3
level by restoring
52.9% (P < 0.01) T3 expression compared with that in the NCG."

"TSH levels in the NCG increased significantly by 89.5% (P < 0.01) and were normal
(P > 0.05) in groups receiving high and medium concentrations of GABA
(Fig. 1)
compared with those in the control group."


"GABA treatment exerted better
protective effects than thyroid tablets (Fig. 3-c) against fluoride-induced damage of the
ultrastructure of thyroid follicles."


 
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mrchibbs

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Really nice!

Taurine was also found to have this effect, and since Taurine is known to increase GABA, the puzzle pieces are starting to come together.

These days I'm really trying to optimize GABA production and achieve deep sleep, it seems to be a fundamental aspect of recovery/tissue regeneration.
 
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Mauritio

Mauritio

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Really nice!

Taurine was also found to have this effect, and since Taurine is known to increase GABA, the puzzle pieces are starting to come together.

These days I'm really trying to optimize GABA production and achieve deep sleep, it seems to be a fundamental aspect of recovery/tissue regeneration.
Totally agreed . I think it's underrated how important GABA is not just for protection /anti-excitation ,but also as a directly pro-metabolic molecule . (It increases heat production for example)
 

lampofred

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GABA is protective against all poisons because it redirects your body's energetic resources internally for repair, maintenance, and detoxification as opposed to externally for growth. It's hard to increase though, the only big-picture way I have heard so far is keeping calcium higher than phosphate and minimizing iron, and probably avoiding PUFA as well.
 
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Mauritio

Mauritio

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You've been on fire lately @Mauritio. Thanks for another great thread. Watching :)
Thanks :)

GABA is protective against all poisons because it redirects your body's energetic resources internally for repair, maintenance, and detoxification as opposed to externally for growth. It's hard to increase though, the only big-picture way I have heard so far is keeping calcium higher than phosphate and minimizing iron, and probably avoiding PUFA as well.
A GABA supplement might be an option , it has been shown that it proably does cross the BBB , it is hard to find a pure, non-allergenic source though.
 

Explorer

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Would Valerian root extract tincture that increases the GAD enzyme which then converts more Glutamate into the GABA work for this aswell?
 

Phosphor

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I have tried GABA powder and absolutely nothing happens even at high doses. However I get fine results from L-theonine to raise GABA.
 

mrchibbs

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I have tried GABA powder and absolutely nothing happens even at high doses. However I get fine results from L-theonine to raise GABA.

I think combining things which are known to increase GABA like magnesium, taurine, theanine, b6 etc. is the most practical approach.
 

Phosphor

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I also took "200mg of Zen" which is GABA plus theonine, and it was nowhere near as effective as theonine by itself. I think that falls into the "we are all different" category.
 

Ben.

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Since i had some serious sleeping issues at the end of 2019/start of 2020 i bought a GAGAB supplement. I never ended up using it but i gave it to my father, who has insane health issues and also suffers from serious insomnia for years/majority of his life.

From all the things he tried the GABA supplement was the first thing that allowed him to sleep 6 hour straight trough in many years.

I would refrain from repeated use tho. Same with most medication/supplements. With GABA the effectiveness of it reduces with repeated uses, may even cause problems if taken over a longer period of times.
 

cjm

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You've been on fire lately @Mauritio. Thanks for another great thread. Watching :)

+1. I'm finding them personally relevant. Please keep reading my diary.

These days I'm really trying to optimize GABA production and achieve deep sleep, it seems to be a fundamental aspect of recovery/tissue regeneration.

I didn't realize it until yesterday but I'm trying to do the same thing. The mental hurdle to get over with GABA for me was the addictive potential of the nastier GABAergic drugs, benzos and phenibut to a lesser extent.

I had bought some GABA for making active creams and it arrived yesterday. I made a quick solution with vodka and applied topically all over, but then I decided to take it orally (~500mg), and can confirm it worked to extinguish intrusive/unwanted thoughts before bed: Intrusive / Unwanted Thoughts Due To Low GABA Signalling

I woke up early and wired like normal but it wasn't an endurance event to actually get to bed.

I'm gathering my thoughts as I'm typing but something clicked in my head when I read GHB (GABA agonist) is an athletic performance enhancer. I use a vibration platform to self-massage tight joints and muscles and this morning was a more productive session than normal.

GABA activity, for me, it seems, allows intense sensation to develop in my body without getting distracted (basically going up into my head and daydreaming to avoid feeling). In particular, my diaphragm will "zap" me when my mania gets out of control but I can stand on the vibrating platform in a way that massages it. It's not painful but it's not enjoyable, just intense and distracting. I can feel deadness/knots just below my shoulder joints in my delts and in my thighs just below the hip: stubborn spots that don't want to join the rest of the party. If I can get the feeling flowing through them in an unimpeded manner, I think my distraction will go away. Moving around won't be such a chore. I was an athlete once, not a graceful one, and I can see how GABA could improve performance by enhancing recovery via active inhibition.
 

cjm

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A GABA supplement might be an option , it has been shown that it proably does cross the BBB , it is hard to find a pure, non-allergenic source though.

"Injected GABA is usually considered to enter only the fetal or infant brain, because of the "blood brain barrier" of the more mature organism. However, Nasonov and his students have shown that many kinds of stress will eliminate the barrier and that it can be interpreted as a physical state of the neuron, governing solubility. This suggests that GABA itself may be able to enter the brain and exert a beneficial inhibitory action if the brain is in a state of exhaustion from stress."

BIOPHYSICAL APPROACH TO ALTERED CONSCIOUSNESS, p. 196

(Couldn't find the referenced study: NASONOV, D.N , and ALEKSANDROV, V. Ya : The Reactions of Living Tissue to External Influences. Pub. A S USSR, Moscow-Leningrad, 1940)
 

cjm

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I'm expecting the GABA in the mail today but I took a heavy dose of glycine powder last night, ~30g in two divided doses. Can confirm similar feeling to when taking 500mg GABA.
 
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Mauritio

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PICAMILON - a molecular combination of Vitamin B3 and GABA that crosses the BBB.

Has anybody tried it ?


 
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cjm

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PICAMILON - a molecular combination of Vitamin B3 and GABA that crosses the BBB.

Has anybody tried it ?


Never heard of it but I knew there were more of these analogs out there. I'll reply in the other thread.

I am taking straight GABA now, 250mg-500mg at a time, a few times a day.

Will share thoughts next week after a few more days of this.
 

cjm

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Not fluoride related but in the GABA house:

Cavagnini, F., Pinto, M., Dubini, A., Invitti, C., Cappelletti, G., & Polli, E. E. (1982). Effects of gamma aminobutyric acid (GABA) and muscimol on endocrine pancreatic function in man. Metabolism, 31(1), 73–77. doi:10.1016/0026-0495(82)90029-4

[Dosage = 5-10g. In vitro study tho]

DISCUSSION

The presence in the rat and human pancreatic islets of GABA concentrations as high as those found in the brain and the neurotransmitter role played by this amino acid in the CNS, makes the hypothesis attractive that GABA is also involved in the regulation of endocrine pancreatic function. To our knowledge, this possibility has never been investigated in humans and only preliminary information on this issue is available from animal studies. A potentiation of glucose-induced insulin secretion by GABA has been suggested by Lernmark (personal communication to Gylfe et al.) in laboratory animals. By contrast, according to Kobayashi et al., GABA has no effect on glucose or amino acid-induced insulin release from rat pancreatic islets in vitro. In our study, oral administration of GABA to normal subjects, caused a moderate but significant and dose-dependent increase of plasma IRI, CP and IRG levels, without affecting blood glucose concentration. In contrast, administration of muscimol, a specific GABA receptor agonist, did not alter the above parameters. It cannot be completely excluded that inadequacy of the muscimol dose was responsible for its lack of effect (the dose of 5 mg was chosen as the highest which can be safely administered to normal subjects); however, it must be noticed that the same dose of the drug is capable of eliciting growth hormone and prolactin release in man (personal unpublished observation). Collectively, these results favor the idea that GABA plays a specific role in the control of endocrine pancreatic secretion. Its mechanism of action is still undefined. The lack of effect of muscimol would indicate that GABA's effects are not mediated through the activation of specific receptors. GABA might exert its regulatory function in the pancreatic islets by supplying energy for hormone synthesis through the GABA shunt or act in some other way by an intermediate product of its metabolism. Also to be considered is the possibility that our results merely reflect a nonspecific effect of GABA, related to its amino acid nature.

The significance of the high concentrations of GABA in the endocrine pancreas is unclear. The possibility that GABA represents a derivative product of glucose !7 or putrescine 19 metabolism is unlikely; the high GAD activity which parallels the high GABA concentrations in the islets 12'13 suggests that at least part of GABA in this site is locally synthesized from glutamate. In the pancreatic islets, GABA seems to be confined within the/~-cell, as indicated by the dramatic drop of its content in this tissue in streptozotocin treated rats. ~3-~5 This suggests a close association between GABA and insulin secretion. Our data, while clearly showing an insulin-releasing activity of GABA, indicate that this compound also promotes glucagon secretion. The rise of IRG in plasma following GABA administration, although delayed by 30 min as compared to IRI increase, cannot be ascribed to this latter effect, since the plasma glucose concentration remained constant throughout the experiment and insulin appears to be inhibitory to glucagon secretion. 1°'21 Blood glucose levels did not change significantly following GABA or muscimol administration. Since both insulin and glucagon were increased by GABA, their effect on hepatic glucose output might have been counterbalanced. In vitro studies aimed at better defining the dose-response relationships between GABAergic compounds and endocrine pancreatic secretion are required to settle this question. The possibility that GABA modulates the secretion of other islet hormones such as pancreatic polypeptide, vasoactive intestinal peptide or somatostatin has not been investigated. Studies in this direction as well as a search for GABA receptors and specific localization of GAD in the pancreatic islets could help to clarify the role of this amino acid in the physiology of the endocrine pancreas.


~~~


"The amino acids that constitute protein have many hormone-like functions in their free state. When our glucose (glycogen) stores have been depleted, we convert our own tissue into free amino acids, some of which are used to produce new glucose. The amino acids cysteine and tryptophan, released in large quantities during stress, have antimetabolic (thyroid-suppressing) and, eventually, toxic effects. Hypothyroidism itself increases the catabolic turnover of protein, even though general metabolism is slowed.

Other amino acids act as nerve-modifiers (“transmitters”), causing, for example, excitation or inhibition.

Some of these amino acids, such as glycine, have a very broad range of cell-protective actions.


Their physical properties, rather than their use for production of energy or other metabolic function, are responsible for their important cytoprotective actions."
 
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cjm

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Wanted to update on my little experiment that I find GABA useful for quickly reducing stress, but it may induce quick tolerance as I found myself irritable the day after taking an effective 3g dose while under acute stress. Essentially I've lost interest in supplemental GABA being a fundamental factor in my long-term recovery, though it has a spot in my toolkit now.
 
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Mauritio

Mauritio

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Wanted to update on my little experiment that I find GABA useful for quickly reducing stress, but it may induce quick tolerance as I found myself irritable the day after taking an effective 3g dose while under acute stress. Essentially I've lost interest in supplemental GABA being a fundamental factor in my long-term recovery, though it has a spot in my toolkit now.
Have you seen the thread on fasoracetam ? It might be interesting for you since there doesn't seem to be any tolerance...
 

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