GABA decreases flouride inuced hypothyroidism; more effective than thyroid hormone

GelatinGoblin

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Not fluoride related but in the GABA house:

Cavagnini, F., Pinto, M., Dubini, A., Invitti, C., Cappelletti, G., & Polli, E. E. (1982). Effects of gamma aminobutyric acid (GABA) and muscimol on endocrine pancreatic function in man. Metabolism, 31(1), 73–77. doi:10.1016/0026-0495(82)90029-4

[Dosage = 5-10g. In vitro study tho]

DISCUSSION

The presence in the rat and human pancreatic islets of GABA concentrations as high as those found in the brain and the neurotransmitter role played by this amino acid in the CNS, makes the hypothesis attractive that GABA is also involved in the regulation of endocrine pancreatic function. To our knowledge, this possibility has never been investigated in humans and only preliminary information on this issue is available from animal studies. A potentiation of glucose-induced insulin secretion by GABA has been suggested by Lernmark (personal communication to Gylfe et al.) in laboratory animals. By contrast, according to Kobayashi et al., GABA has no effect on glucose or amino acid-induced insulin release from rat pancreatic islets in vitro. In our study, oral administration of GABA to normal subjects, caused a moderate but significant and dose-dependent increase of plasma IRI, CP and IRG levels, without affecting blood glucose concentration. In contrast, administration of muscimol, a specific GABA receptor agonist, did not alter the above parameters. It cannot be completely excluded that inadequacy of the muscimol dose was responsible for its lack of effect (the dose of 5 mg was chosen as the highest which can be safely administered to normal subjects); however, it must be noticed that the same dose of the drug is capable of eliciting growth hormone and prolactin release in man (personal unpublished observation). Collectively, these results favor the idea that GABA plays a specific role in the control of endocrine pancreatic secretion. Its mechanism of action is still undefined. The lack of effect of muscimol would indicate that GABA's effects are not mediated through the activation of specific receptors. GABA might exert its regulatory function in the pancreatic islets by supplying energy for hormone synthesis through the GABA shunt or act in some other way by an intermediate product of its metabolism. Also to be considered is the possibility that our results merely reflect a nonspecific effect of GABA, related to its amino acid nature.

The significance of the high concentrations of GABA in the endocrine pancreas is unclear. The possibility that GABA represents a derivative product of glucose !7 or putrescine 19 metabolism is unlikely; the high GAD activity which parallels the high GABA concentrations in the islets 12'13 suggests that at least part of GABA in this site is locally synthesized from glutamate. In the pancreatic islets, GABA seems to be confined within the/~-cell, as indicated by the dramatic drop of its content in this tissue in streptozotocin treated rats. ~3-~5 This suggests a close association between GABA and insulin secretion. Our data, while clearly showing an insulin-releasing activity of GABA, indicate that this compound also promotes glucagon secretion. The rise of IRG in plasma following GABA administration, although delayed by 30 min as compared to IRI increase, cannot be ascribed to this latter effect, since the plasma glucose concentration remained constant throughout the experiment and insulin appears to be inhibitory to glucagon secretion. 1°'21 Blood glucose levels did not change significantly following GABA or muscimol administration. Since both insulin and glucagon were increased by GABA, their effect on hepatic glucose output might have been counterbalanced. In vitro studies aimed at better defining the dose-response relationships between GABAergic compounds and endocrine pancreatic secretion are required to settle this question. The possibility that GABA modulates the secretion of other islet hormones such as pancreatic polypeptide, vasoactive intestinal peptide or somatostatin has not been investigated. Studies in this direction as well as a search for GABA receptors and specific localization of GAD in the pancreatic islets could help to clarify the role of this amino acid in the physiology of the endocrine pancreas.


~~~


"The amino acids that constitute protein have many hormone-like functions in their free state. When our glucose (glycogen) stores have been depleted, we convert our own tissue into free amino acids, some of which are used to produce new glucose. The amino acids cysteine and tryptophan, released in large quantities during stress, have antimetabolic (thyroid-suppressing) and, eventually, toxic effects. Hypothyroidism itself increases the catabolic turnover of protein, even though general metabolism is slowed.

Other amino acids act as nerve-modifiers (“transmitters”), causing, for example, excitation or inhibition.

Some of these amino acids, such as glycine, have a very broad range of cell-protective actions.


Their physical properties, rather than their use for production of energy or other metabolic function, are responsible for their important cytoprotective actions."
Very, very interesting.
 

Bodhi

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We all know Fluoride is a Halogen just like Iodine, the Fluoride replaces the Iodine in the Thyroid so less iodine can be converted into T4/T3 ...
So adding Taurine or GABA is just a compensation/support/ "fix" but does not replace the fluoride from your thyroid ... Better use iodine and selenium ..
Ray Peat diet and water filters ....
 

SonOfEurope

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GABA is protective against all poisons because it redirects your body's energetic resources internally for repair, maintenance, and detoxification as opposed to externally for growth. It's hard to increase though, the only big-picture way I have heard so far is keeping calcium higher than phosphate and minimizing iron, and probably avoiding PUFA as well.

+1 on Iron.

Let's not forget having lower BF%, better liver function for estrogen clearance, proper circadian rhythm, plenty of red light, as much time under the sun free of stress and a balanced amino acid profile with ample potassium, zinc, magnesium and non inflammatory Carbohydrates - all things that increase endogenous Progesterone Production and hence systemic GABA.
 
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rayban

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We all know Fluoride is a Halogen just like Iodine, the Fluoride replaces the Iodine in the Thyroid so less iodine can be converted into T4/T3 ...
So adding Taurine or GABA is just a compensation/support/ "fix" but does not replace the fluoride from your thyroid ... Better use iodine and selenium ..
Ray Peat diet and water filters ....

How to accurately measure iodine and selenium to see if I should bother supplementing?

Also what if you use Listerine? I use the soft one some nights.
 

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