Any Idea As To Why Antihistamines Cause Drowsiness?

Discussion in 'Supplements' started by solaire_of_astora, Jan 29, 2014.

  1. solaire_of_astora

    solaire_of_astora Member

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    I don't really know anything about how antihistamines work, but if histamine is blocked, then serotonin must be reduced, increasing CO2, thus lowering the stress hormones, particularly adrenaline. Does that sound about right?
     
  2. kiran

    kiran Member

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    Histamine is involved in wakefulness, I suppose it has a larger effect if your metabolism is low. Antihistamines can also be anti-cholinergic (cyproheptadine is, cetirizine isn't), another stress hormone.
     
  3. Ben

    Ben Member

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    Antihistamines that are anticholinergic in particular reduce activation of the parasympathetic nervous system and increase activation of the sympathetic counterpart, this can cause pupil dilation, erectile dysfunction, changes in blood flow, and other "sympathetic" functions. Histamine itself, as Kiran said, is involved in wakefulness, and also arousal. I think it's healthiest to take both an inhibitor of the PSNS and SNS to reduce autonomic arousal overall. Although both should be minimized, an imbalance isn't good.

    By the way, are you folks prescribed cyproheptadine, cetirizine, hydoxyzine, and other anti-histamine agents, or do you obtain it from another country like cynomel can be bought from Mexico without a prescription? Or is it over-the-counter in whatever country you're in?
     
  4. OP
    solaire_of_astora

    solaire_of_astora Member

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    Thanks for the info guys. I'm using Benadryl for now, but I plan on trying Cyproheptadine soon. I'm most likely going to buy it online without a prescription.
     
  5. Mittir

    Mittir Member

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    RP recommended additive free pure Benadryl and Cyproheptadine as anti-histamine.
    He warned against using certain antihistamines, which has chlorine or fluorine attached
    to carbon molecules. These causes liver problems .
    Cetirizine and hydroxyzine have same problem.
    source : viewtopic.php?f=68&t=1035&start=50#p13904
     
  6. Ben

    Ben Member

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    Benadryl acts as an SSRI, not sure if RP is aware of this or not.
     
  7. HDD

    HDD Member

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    Isn't that only in higher dosage?
     
  8. Ben

    Ben Member

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    This is a quote from wikipedia. The cited abstract on pubmed didn't have anything about benadryl.

    I would be cautious about Benadryl because a lot of people have gotten irreversible issues like ringing in the ears from it. If someone has low serotonin but high histamine, it could be a good idea, but for an average person I wouldn't recommend it.
     
  9. sladerunner69

    sladerunner69 Member

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    Because you can't have your cake and eat it too.

    Low serotonin/histamine euphoria or energy/alertness. You can only choose one.
     
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