haidut said:NathanK said:post 103280 I remember reading a few biotin+chromium picolinate studies similar to this. Would the mechanism for restoring glucose metabolism just be biotin's suppression of FFA since niacinamide and aspirin have shown the same?
No, biotin does more than suppress FFA. It also restarts the Krebs cycle's usage of pyruvate when the cell is stuck in excess glycolysis. So, instead of the cell producing lactate biotin forces the utilization of pyruvate by the Krebs cycle and later by the electron transport chain. The Krebs cycle stimulation is done by enhancing the activity of pyruvate carboxylase and thus preventing the building of pyruvate and eventually lactate. With niacinamide also lowering excessive FFA and raising the levels of NAD (needed for oxidative metabolism), and thiamine stimulating pyruvate dehydrogenase these 3 vitamins are key for maintaining oxidative metabolism even in sick people. I would add pyridoxine / P5P to the group as it was shown to benefit glycolytic and hyperglycemic states as well and it is a cofactor for some of the enzymes in the Krebs cycle. So, a combination of thiamine, niacinamide, pyridoxine / P5P, and biotin should restore oxidative glucose metabolism, provided the electron transport chain is not blocked by something like excessive NO. But methylene blue can take care of the latter
Biotin also increases ATP.Will this have a positive effect on steroid synthesis?
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