Biotin Reduces Ammonia Levels In Brain And Blood

[TubZy]

Thanks for the info. If biotin can reduce NO, then it is becoming more and more interesting for a number of conditions. Btw, on one of my threads on biotin I posted a study showing that uniquely among all the vitamins known in clinical practice, biotin leads to elevated levels of ATP and CO2 as a result of dramatically improved glucose metabolism. Here is the thread.
viewtopic.php?f=10&t=5862

The study used 100 microMol biotin and was done in vitro. I can't seem to find any reliable data on humans that shows how much biotin needs to be ingested to get this concentration. However, the same group that published the study on biotin causing elevation in ATP and CO2 published several other studies in rats showing prevention of diabetes and reversal of glucose metabolism issues with human equivalent doses of 10mg-20mg per day for 4-8 weeks.
Even more interestingly, Peat once wrote that both Hans Selye and Albert Szent-Györgyi thought that cancer is essentially caused by persistent biotin deficiency. I can't find the direct quote but here is another article by Peat hinting at biotin being helpful:
viewtopic.php?t=1268
"...Heart failure, shock, and other problems involving excess lactic acid can be treated "successfully" by poisoning glycolysis with dichloroacetic acid, reducing the production of lactic acid, increasing the oxidation of glucose, and increasing cellular ATP concentration. Thyroid, vitamin B1, biotin, etc., do the same."

I have no idea why Peat did not include cancer in the above list of condtions treatable by "poisoning" glycolysis, especially given that he mentions using DCA?!?! But we can make the connection.

What is known now is that biotin deficiency does result in highly upregulated aerobic glycolysis and inhibition of oxidative phosphorylation, manifested in high lactate and low CO2. So, essentially the Warburg Effect.
In summary, biotin supplementation leads to:

• 
  increased ATP
  increased CO2
  decreased lactate in serum, brain, liver and muscle
  restored insulin sensitivity and glucose tolerance
  direct prevention of developing diabetes (I don't know of another vitamin that has this effect)
  decreased NO
  decreased ammonia
  decreased glutamate
  decreased fatty acid synthase (an effect proposed by Peat to be a major factor behind aspirin preventing cancer)

The list probably goes on and on but even in its current form it is quite impressive. Maybe thiamine + biotin would be ultimately Peat supplement, assuming all problems stem from low CO2 and increased fatty acid oxidation...

Those bolded bullets are probably why biotin is good for hair.

 

[Antonello]

I found I get really anxious and nightmares with biotin. Thoughts?

Me too with extra 5mg on top of Enirgin I feel cold, anxious and on top of that insomnia and nightmares.
I haven’t experienced the glycogen storage benefit quite the contrary I need to eat more frequently for keep the adrenaline low.

 

[ecstatichamster]

2. Human studies of biotin
Survey of the Effect of Biotin on Glycemic Control and Plasma Lipid Concentrations in Type 1 Diabetic Patients in Kermanshah in Iran (2008-2009)
Oral glucose tolerance test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients. - PubMed - NCBI
Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type... - PubMed - NCBI
The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a pla... - PubMed - NCBI
Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, dou... - PubMed - NCBI
Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. - PubMed - NCBI
Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo-controlled, double-bl... - PubMed - NCBI

3. Animal studies of biotin

 

[ddjd]

is it true biotin can be bad for hypothyroid people?

 

[Lokzo]

I found I get really anxious and nightmares with biotin. Thoughts?

Because Biotin INCREASES CORTISOL.
CYP1B1 Enzyme: Function, Genetics, Ways to Increase / Decrease It - Selfhacked

And also, I find that Biotin makes me feel as ***t as Glutamine does...It's like anything that raises the glutaminergic neurotransmission, makes me slur my speech/brain foggy effect.

A biotin-coupled bifunctional enzyme exhibiting both glutamine synthetase activity and glutamate decarboxylase activity. - PubMed - NCBI

OR Biotin is horrendous for the gut bacteria.... I've seen studies showing how Biotin helps to feed Candida albicans and some other nasty bacteria in the gut.

 

[Luann]

personally breathing through my nose is very clear and deep after continuous large doses of biotin and a clear flowing feeling in the head like the opposite of a headache. Lactic acid buildup in the legs on an intense bike ride is also delayed.

i guess that correlates well with all the above mentioned mechanisms of action.

This just sounds glorious. I have chronic neck and sinus stuff going on and that "clear" feeling is amazing when it happens...I'm going to go have a biotin tablet!