Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.
As some of my own studies with cancer recently demonstrated, vitamins are no laughing matter when it comes to their ability to treat very serious conditions. This seems to be especially true in regards to the B vitamins, which are required co-factors for most of the metabolic reactions inside...
High dose biotin supplements can falsely elevate TSH or other thyroid lab tests.
@Koveras discussed this in March, but maybe a separate post can emphasize the concern.
Confusing Blood Tests - High FT3 And FT4 And High TSH
This is ONLY a caution about interpreting thyroid LAB tests with recent...
Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis - ScienceDirect
And other studies also shown that biotin lowers free fatty acid levels.
Biotin Decreases Serum Free Fatty Acids
There is old studies reporting animals on a fat free diet could get symptom free when they include liver in their feed , I think that is because it has biotin in much higher level than any other food.
Mechanism of blocked lipogenesis induced in rats by feeding extremely hydrogenated fat | AJP...
In support of Ray's views of CO2 as one of the main factors in mitochondrial biogenesis and health, and as such in a host of health conditions, this study found that carbonic anhydrase levels are higher and the enzyme itself is more active in both aging and degenerative conditions. Inhibiting...
what do you think?
Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice
SIRT1, a longevity regulator and NAD+-dependent deacetylase, plays a critical role in promoting metabolic fitness...
it is on peripheral blood mononuclear cells, so i dont know how much it applies to whole body biotin status.
Human peripheral blood mononuclear cells: ; Inhibition of biotin transport by reversible competition with pantothenic acid is quantitatively minor. - PubMed - NCBI
A transporter...
Effects of Biotin Supplementation in the Diet on Adipose Tissue cGMP Concentrations, AMPK Activation, Lipolysis, and Serum-Free Fatty Acid Levels. - PubMed - NCBI
Several studies have shown that pharmacological concentrations of biotin decrease hyperlipidemia. The molecular mechanisms by which...
Biotin augments acetyl CoA carboxylase 2 gene expression in the hypothalamus, leading to the suppression of food intake in mice. - PubMed - NCBI
It is known that biotin prevents the development of diabetes by increasing the functions of pancreatic beta-cells and improving insulin sensitivity...
it shows biotin supplement can disturb thyroid test,maybe better to not take it prior to testing thyroid.
Biotin interference on TSH and free thyroid hormone measurement. - PubMed - NCBI
Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats. - PubMed - NCBI
Abstract
The aim of this study was to investigate the effects of a combination of nutrients on physical performance, oxidative stress and mitochondrial biogenesis in...
http://www.ncbi.nlm.nih.gov/pubmed/2515138
"We have studied testicular function in the biotin-deficient rat biochemically and morphologically. Serum testosterone and luteinizing hormone (LH) levels were decreased significantly in the deficient rats. Administration of biotin or gonadotropins to...
https://www.dsm.com/markets/anh/en_US/C ... iotin.html
Biotin has been studied primarily as a benefit to hoof integrity in cattle, however, a number of recent studies have shown that feeding supplemental biotin at the rate of 20 mg/cow/day increased milk production significantly (Bonomi et al...
The glucose and lipid lowering effects of biotin are well known. A combination of biotin and chromium picolinate is approved as a drug for type II diabetes. The study below goes a step further. It mentions that in humans, 16mg of biotin daily for a week restored glucose metabollism in...
I posted some studies on biotin, including its effects on blood lipids and insulin sensitivity. There have also been discussions on the forum about supplements or drugs that promote glycogen synthesis, since glycogen synthesis and levels are both low in hypothyroid people. In addition to the...
I posted a study some time ago showing that biotin dramatically increases CO2 production from glucose and as a result increases ATP levels several fold. It was an in vitro study and when I calculated the dosage I freaked out b/c my numbers were showing a human would need at least 200mg biotin to...
I was wondering what might be good dosages of thiamine, riboflavin, niacinamide, pyridoxine, and biotin.
I currently take the following and was wondering if the doses are OK: (I recently stopped for a few days then restarted as I find I feel better when I take them)
thiamine 100mg
riboflavin...
Rat study, but should be applicable to humans as well. Human equivalent dosage is about 20mg of biotin per day, which may seem very high to some. However, it has been shown to be safe in humans for up to a year administration and incidentally this is the dose used in humans to lower cholesterol...
Given the number of threads on the forum from people experiencing reduced insulin sensitivity or weight gain on Peatarian diet I thought that I post some threads on how these conditions can be ameliorated by specific substances that Peat has written about. This thread is about vitamin B7...