glucose metabolism

A great study, which both highlights the dangers of statins while also providing a plausible mechanism for those side effects that both FDA and Big Pharma vehemently continue to dispute. This plausible mechanism involves the inhibition of vitamin K2 (MK-4) synthesis, which requires the same...

As my readers know, the role of metabolism in the initiation and progression of cancer is enjoying renewed interest, after more than a century of neglect and deliberate suppression. One of the promising drugs that target metabolic pathways is dichloroacetate (DCA). The main mechanism of action...

As many readers know, there is an epidemic of vitamin D deficiency. It is of worldwide proportions, but is visible mainly in "developed" countries in the Western world. The official stance of mainstream medicine is that while vitamin D deficiency is undesirable, it does not really have much...

I posted a study recently showing that low-carb diets increase risk for a potentially fatal heart rhythm disorder known as AFib. https://raypeatforum.com/community/threads/low-carb-diets-may-cause-lethal-heart-rhythm-disorder-afib.28169/ Now this new, also human, study below shows that even a...

This is great human study that addresses two key questions people have often asked Peat in regards to SFA vs. PUFA. As Peat has mentioned several times, during stress (exercise in this case) PUFA is preferentially oxidized while SFA is stored. The preferential oxidization of PUFA during stress...

At 2 weeks HIIT 3X/Week I'd add 1 hour or more brisk walking/day on 'off' days

Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin. - PubMed - NCBI Skeleton was considered as a dynamic connective tissue, which was essential for mobility, calcium homeostasis, and hematopoietic niche. However more and more evidences indicate that skeleton works not...

People that kiss with the eyes open to monitor if the surroundings are safe, Effect of experimental potassium deficiency on glucose and insulin metabolism "Our results indicate that mild-to-moderate potassium depletion, of a magnitude commonly encountered in clinical practice, does cause a...

The glucose and lipid lowering effects of biotin are well known. A combination of biotin and chromium picolinate is approved as a drug for type II diabetes. The study below goes a step further. It mentions that in humans, 16mg of biotin daily for a week restored glucose metabollism in...

Ray has written about this phenomenon so many times, and it also underscores the futility of the attempt to cure diabetes by making people oxidize fat more. According to this study, with aging the human mitochondria progressively lose the ability to oxidize glucose. They can oxidize fat just...

Several people on the forum have asked for measures on how to increase glycogen storage in the liver. Hypothyroid people have issues with glycogen storage and having a substance that can increase such storage would be helpful. It looks like famotidine is one such substance. It dose dependently...

http://www.ncbi.nlm.nih.gov/pubmed/24127499 For a long time the only functions attributed to the skeleton were locomotion and calcium storage. Over the last decade, this view has changed. Genetic studies in mice have shown that bone metabolism is regulated by the autonomic nervous system and...

http://www.cell.com/abstract/S0092-8674%2810%2900621-5 Highlights ▸ Insulin signaling in mouse osteoblasts increases activity of the hormone osteocalcin ▸ Osteocalcin activation depends on the acidic pH in the bone resorption area ▸ Enhanced osteocalcin activity promotes glucose metabolism...

Not really news for Peat followers but this study might give a hint on what happens when we suppress lipolysis e.g. via Niacinamide: http://www.plosbiology.org/article/info ... io.1001485 When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in peripheral tissues...