Biotin Restores Glucose Metabolism Even In Type I Diabetes

Discussion in 'Scientific Studies' started by haidut, Oct 7, 2015.

  1. haidut

    haidut Member

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    The glucose and lipid lowering effects of biotin are well known. A combination of biotin and chromium picolinate is approved as a drug for type II diabetes. The study below goes a step further. It mentions that in humans, 16mg of biotin daily for a week restored glucose metabollism in insulin-dependent patients for whom insulin therapy had been withdrawn. In other words, biotin effectively substituted for insulin therapy. In addition, the study replicated the reported results in humans by using a genetically diabetic mouse model. The biotin doses used in the mouse study were equivalent to 15mg and 30mg per day for a human, with the 30mg daily having stronger effect on lowering blood glucose and lowering hyperinsulinemia.
    So, people here struggling with glucose issues can try biotin for a week, or a combination of biotin, pyridoxine, thiamine, niacinamide and riboflavin as they are all involved in glucose metabolism. I don't think it gets any better than that, as I don't know of any drug that acts as fast as biotin (1 week) and with such beneficial effects.

    http://www.ncbi.nlm.nih.gov/pubmed/3280936
    "...Because biotin treatment may lower blood glucose in insulin-dependent diabetes, we chose to study such an effect in non-insulin dependent diabetes. Twenty-six diabetic KK mice, moderately hyperglycemic and insulin resistant, were treated for 10 weeks: 9 animals with 2 mg of biotin/Kg, 8 with 4 mg of biotin/Kg, and 9 with saline (controls). Blood glucose levels, oral glucose tolerance, insulin response to oral glucose, and blood glucose decrease in response to insulin were quantitated. Compared to controls, biotin treatment lowered post-prandial glucose levels, and improved tolerance to glucose and insulin resistance. Serum immunoreactive insulin levels in biotin treated mice were like the controls."

    "...Relationships between vitamin status, glucose metabolism and insulin have been demonstrated in animals and humans (1). Vitamin B6 deficiency induces intolerance to glucose (2-5). Treatment with pharmacological doses of B6 improved carbohydrate tolerance in gestational diabetic women (6,7) and in women taking oral contraceptives (8). Riboflavin lowers or increases fasting blood sugar levels in riboflavin-deficient dogs (9-11): intake of high doses of vitamin C appears to be diabetogenic (1). Glucose tolerance is impaired in vitamin A-deficient rats (12). Biotin deficiency has been linked to hyperglycemia and decreased utilization of glucose (13-15). High-dose biotin (16 mg/day) for one week lowered fasting blood glucose levels in non-biotin deficient, insulin-dependent diabetic patients when insulin was withdrawn during biotin administration (16). Because biotin treatment may lower blood glucose levels in insulin-dependent diabetes, we initiated a further study on such a biotin effect in noninsulin-dependent diabetes."
     
  2. poilochio

    poilochio Member

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    Wonderful thank you haidut .....just ordered my biotin ..i will report back once i tried it out ....ps. yes im a typ 1 diabetic since 1.5 years.
     
  3. Tarmander

    Tarmander Member

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    Welcome to the forum brother t1d! I would love to hear about your experiences with biotin...don't go disappearing.
     
  4. OP
    haidut

    haidut Member

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    From another study - optimal doses of biotin for lowering glucose and increasing glycogen synthesis seem to be in the range 15mg - 20mg per dose. Higher and lower doses have less of an effect. This dose can be taken several times a day but even once daily was enough to reverse insulin resistance and type II diabetes. Optimal effect are seen within a month but are apparent even after 24 hours.
     
  5. NathanK

    NathanK Member

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    I remember reading a few biotin+chromium picolinate studies similar to this. Would the mechanism for restoring glucose metabolism just be biotin's suppression of FFA since niacinamide and aspirin have shown the same?
     
  6. OP
    haidut

    haidut Member

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    No, biotin does more than suppress FFA. It also restarts the Krebs cycle's usage of pyruvate when the cell is stuck in excess glycolysis. So, instead of the cell producing lactate biotin forces the utilization of pyruvate by the Krebs cycle and later by the electron transport chain. The Krebs cycle stimulation is done by enhancing the activity of pyruvate carboxylase and thus preventing the building of pyruvate and eventually lactate. With niacinamide also lowering excessive FFA and raising the levels of NAD (needed for oxidative metabolism), and thiamine stimulating pyruvate dehydrogenase these 3 vitamins are key for maintaining oxidative metabolism even in sick people. I would add pyridoxine / P5P to the group as it was shown to benefit glycolytic and hyperglycemic states as well and it is a cofactor for some of the enzymes in the Krebs cycle. So, a combination of thiamine, niacinamide, pyridoxine / P5P, and biotin should restore oxidative glucose metabolism, provided the electron transport chain is not blocked by something like excessive NO. But methylene blue can take care of the latter:):
     
  7. johnwester130

    johnwester130 Member

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    Biotin is the most bought supplement on Amazon, with over 5000 reviews.

    Why ?
     
  8. OP
    haidut

    haidut Member

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    Probably because every cosmetic outfit recommends it left and right and people are bombarded with information on how it is the one supplement that will improve nail, skin and hair quality. There is some merit to these claims, especially the nails part.
     
  9. SQu

    SQu Member

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    Really? I have terrible nails. And glucose oxidation.
     
  10. OP
    haidut

    haidut Member

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    Biotin is not the only factor. Poor protein utilization will also mess up nails, as well as zinc deficiency.
     
  11. SQu

    SQu Member

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    More clues - thank you haidut! Years of over zealous zinc supplementing I suspect did nothing but whiten my hair (gee, thanks - so glad I spent all that money!). These days I just have oysters. protein utilization is something to look into. No doubt that sucks too! But I'll get there!
     
  12. TheHound

    TheHound Member

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    how does one improve protein utilization?
     
  13. OP
    haidut

    haidut Member

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    By eating easily digestible proteins and keeping cortisol low.
     
  14. poilochio

    poilochio Member

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    awwww well thanks brotha....for sure i will report back to you guys .... :hattip
     
  15. poilochio

    poilochio Member

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    would zink do that because it competes with copper? (still learning about all this stuff)
     
  16. NathanK

    NathanK Member

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    Fantastic summation! Благодаря
     
  17. SQu

    SQu Member

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    That's my understanding but please, don't leave it at that, there's long debates here on zinc and copper and they know much more than I do. And it sounds complicated.
    Oh, and tryptophan is also implicated in whitening hair.
     
  18. OP
    haidut

    haidut Member

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    Моля :): (it means you are welcome). I see you've been brushing up on your Eastern European languages. Where do you hail from?
     
  19. johnwester130

    johnwester130 Member

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  20. johnwester130

    johnwester130 Member

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    What is the science behind biotin (supposedly) increasing beauty ?
     
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