Multiple sclerosis (MS) may be due to low metabolism / glucose oxidation

[haidut]

Nothing surprising in the findings of the study, and in fact a great corroboration of the results from the high-dose biotin human study with the aggressive form of MS published several years ago. The officially proposed mechanism of biotin in that study was improved glucose oxidation, mitochondrial respiration and oxygen consumption.

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study - PubMed
The study below used fMRI scans of the brains of MS patients and discovered reduced oxygen consumption (and metabolic rate) of about 15% (compared to health controls) in the neurons of the patients, as well as reduced glucose oxidation (which automatically translates to increased lactate and fatty acid oxidation) of up to 40%. While the study dances around the issue of cause and effect in regards to these findings, it concludes that MS is undoubtedly a mitochondrial disease of completely environmental (non-genetic) nature. As such, we can make the suggestion that MS may be alleviated by pro-metabolic substances that enhance glucose metabolism such as aspirin, niacinamide, thiamine, biotin, thyroid, progesterone, and androgens (for males).

https://doi.org/10.1177/0271678X231224502
Mitochondrial Dysfunction Linked to MS, Further Studies Needed on Metabolic Impact

"...Mitochondrial dysfunction has been indicated as a possible mechanism in the pathophysiology of relapsing/remitting multiple sclerosis (RRMS); however, more studies are needed to determine the value of cerebral oxygen consumption as a predictive biomarker, according to a recent study published in Journal of Cerebral Blood Flow & Metabolism. Although recent progress has made multiple disease-modifying treatments (DMTs) available to patients with MS, patients are still susceptible to disease progression and cerebral atrophy—even when treatments are deemed successful. This reality leads researchers, such as the present authors, to ponder avenues for advancing the current understandings of MS pathophysiology. The authors of the present study detail that the cerebral metabolic rate of oxygen consumption (CMRO2) is reduced in patients with MS compared with otherwise healthy individuals. Due to the observed alterations in oxygen and glucose metabolism, one theory suggests that the brains of patients with MS may be fatigued and affected by energy failures."

"...Reflecting on their findings, the researchers recognize then need for further studies to examine the relationship between reductions in cerebral oxygen consumption and brain atrophy. However, their results do indicate mitochondrial dysfunction as the underlying pathophysiology of RRMS."

 

[lionsmane311]

Nothing surprising in the findings of the study, and in fact a great corroboration of the results from the high-dose biotin human study with the aggressive form of MS published several years ago. The officially proposed mechanism of biotin in that study was improved glucose oxidation, mitochondrial respiration and oxygen consumption.

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study - PubMed
The study below used fMRI scans of the brains of MS patients and discovered reduced oxygen consumption (and metabolic rate) of about 15% (compared to health controls) in the neurons of the patients, as well as reduced glucose oxidation (which automatically translates to increased lactate and fatty acid oxidation) of up to 40%. While the study dances around the issue of cause and effect in regards to these findings, it concludes that MS is undoubtedly a mitochondrial disease of completely environmental (non-genetic) nature. As such, we can make the suggestion that MS may be alleviated by pro-metabolic substances that enhance glucose metabolism such as aspirin, niacinamide, thiamine, biotin, thyroid, progesterone, and androgens (for males).

https://doi.org/10.1177/0271678X231224502
Mitochondrial Dysfunction Linked to MS, Further Studies Needed on Metabolic Impact

"...Mitochondrial dysfunction has been indicated as a possible mechanism in the pathophysiology of relapsing/remitting multiple sclerosis (RRMS); however, more studies are needed to determine the value of cerebral oxygen consumption as a predictive biomarker, according to a recent study published in Journal of Cerebral Blood Flow & Metabolism. Although recent progress has made multiple disease-modifying treatments (DMTs) available to patients with MS, patients are still susceptible to disease progression and cerebral atrophy—even when treatments are deemed successful. This reality leads researchers, such as the present authors, to ponder avenues for advancing the current understandings of MS pathophysiology. The authors of the present study detail that the cerebral metabolic rate of oxygen consumption (CMRO2) is reduced in patients with MS compared with otherwise healthy individuals. Due to the observed alterations in oxygen and glucose metabolism, one theory suggests that the brains of patients with MS may be fatigued and affected by energy failures."

"...Reflecting on their findings, the researchers recognize then need for further studies to examine the relationship between reductions in cerebral oxygen consumption and brain atrophy. However, their results do indicate mitochondrial dysfunction as the underlying pathophysiology of RRMS."

It's interesting how common this is for many different conditions. Why does the same thing seem to happen but manifests in different ways. Dysfunction in glucose metabolism but getting schizophrenia instead of parkinsons or alzheimers? Do you think gene expressions are at play in becoming dysfunctional a certain way or something else by the environment? Maybe heavy metals getting into certain brain regions over others.

https://www.sciencedirect.com/science/article/pii/S0361923023001041

https://www.sciencedirect.com/science/article/pii/S0301008213000531

Brain glucose metabolism in schizophrenia: a systematic review and meta-analysis of 18FDG-PET studies in schizophrenia - PubMed

We report evidence for hypometabolism with large effect sizes in the frontal cortex in schizophrenia without consistent evidence for alterations in other brain regions. Our findings support the hypothesis of hypofrontality in schizophrenia.

pubmed.ncbi.nlm.nih.gov

 

[haidut]

It's interesting how common this is for many different conditions. Why does the same thing seem to happen but manifests in different ways. Dysfunction in glucose metabolism but getting schizophrenia instead of parkinsons or alzheimers? Do you think gene expressions are at play in becoming dysfunctional a certain way or something else by the environment? Maybe heavy metals getting into certain brain regions over others.

https://www.sciencedirect.com/science/article/pii/S0361923023001041

https://www.sciencedirect.com/science/article/pii/S0301008213000531

Brain glucose metabolism in schizophrenia: a systematic review and meta-analysis of 18FDG-PET studies in schizophrenia - PubMed

We report evidence for hypometabolism with large effect sizes in the frontal cortex in schizophrenia without consistent evidence for alterations in other brain regions. Our findings support the hypothesis of hypofrontality in schizophrenia.

pubmed.ncbi.nlm.nih.gov

A lot of the neurological and mental diseases have vastly overlapping symptoms. So, I'd say it is just one disease but with varying severity of symptoms depending on the person. For example, people with Parkinson almost always have psychosis (schizophrenia) and dementia (Alzheimer), and people with mental health disorders often have cognitive (e.g. "Alzheimer") and movement (e.g. "Parkinson", "ALS") disorders. The diagnosis depends on whatever the most pronounced symptom is because doctors are trained in diagnosing specific conditions, but ultimately it is all just symptoms of underlying brain energetic deficiency.

 

[charlie]

A lot of the neurological and mental diseases have vastly overlapping symptoms. So, I'd say it is just one disease but with varying severity of symptoms depending on the person. For example, people with Parkinson almost always have psychosis (schizophrenia) and dementia (Alzheimer), and people with mental health disorders often have cognitive (e.g. "Alzheimer") and movement (e.g. "Parkinson", "ALS") disorders. The diagnosis depends on whatever the most pronounced symptom is because doctors are trained in diagnosing specific conditions, but ultimately it is all just symptoms of underlying brain energetic deficiency.

And from my observations and gatherings, all those afflictions mentioned are simply copper toxicity and/or other heavy metal toxicity like lead, mercury, etc. These metals mess with the energy system of the body.

 

[lionsmane311]

A lot of the neurological and mental diseases have vastly overlapping symptoms. So, I'd say it is just one disease but with varying severity of symptoms depending on the person. For example, people with Parkinson almost always have psychosis (schizophrenia) and dementia (Alzheimer), and people with mental health disorders often have cognitive (e.g. "Alzheimer") and movement (e.g. "Parkinson", "ALS") disorders. The diagnosis depends on whatever the most pronounced symptom is because doctors are trained in diagnosing specific conditions, but ultimately it is all just symptoms of underlying brain energetic deficiency.

Has to be the most interesting perspective I've heard about diseases of the brain. I like it and makes a lot of sense.

Sometimes the solution is very simple despite how complex it is. My hallucinations reduced dramatically from estroban and calcirol to the temples. This versus taking risperidone and getting high prolactin, weight gain, and fatigue with no reduction. More proof it's metabolic

And from my observations and gatherings, all those afflictions mentioned are simply copper toxicity and/or other heavy metal toxicity like lead, mercury, etc. These metals mess with the energy system of the body.

Yes. In my case mercury levels were high in the nail test. Could have been what caused it or made it much worse. Heavy metal concentrations definitely could be the difference between someone that recovers and someone that doesn't.

 

[lionsmane311]

I have a question. If ensuring proper glucose metabolism and nutrients is key to possibly reversing the metabolic dysfunction that brings about these diseases, why is there proof that prolonged fasts like 20-30 days reversed conditions like schizophrenia? Yuri Nikoliav cured 10,000 patients from their schizophrenia with fasting in the 70's. Do you think the brain is reorganizing itself in ways we don't fully understand through the absense of food and nutrients? Or is there something funny or off about the research that was done? @haidut

http://orthomolecular.org/library/jom/1971/pdf/1971-v03n01-p002.pdf

 

[Hidden49]

And from my observations and gatherings, all those afflictions mentioned are simply copper toxicity and/or other heavy metal toxicity like lead, mercury, etc. These metals mess with the energy system of the body.

Yeah having toxicity in these heavy metals creates lots of hydroxyl radicals so the body closes it's sugar and oxygen metabolism as a consequence. Then when you have hypoxic signalling you get latent virus reactivation but these stupid MS researchers think they can fix MS by making an EBV vaccine, no fix the hypoxia first and then viruses like EBV aren't an issue anymore. Nearly everyone has EBV, just it starts causing issues when hypoxic conditions are present.