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  1. UG Krishnamurti

    Glycine side effects. Could someone explain?

    After experimenting with glycine last night (1g in OJ) I've heard a LOUD screaming in my ear while I was sleeping. Woke me up and scared the sh*tout of me xd Knew it was "in my head" because my extremely alert dog was sleeping. I also woke up with extremely dry mouth, grogginess and fatigue...
  2. Pufa-Puffin

    My sleep is literally like a coma. Can't wake up, feeling drunk after I do

    You can stab me or shoot me when sleeping, it would not wake me up. When someone is trying to wake me up, I'm aware of it, but can't control my body and bring myself out of the sleep. Sometimes, I have extremely strong nausea, which I'm also aware of but still can't wake up. When I somehow...
  3. Lokzo

    Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson’s disease patients

    Fatigue is a common symptom of Parkinson’s disease that compromises significantly the patients’ quality of life. Despite that, fatigue has been under-recognized as symptom, its pathophysiology remains poorly understood, and there is no adequate treatment so far. Parkinson’s disease is...
  4. Ismail

    Exhausted after bowel movement

    Hey all, I have at least 2 possibly 3 bowel movements a day. Whenever I’ve finished, I feel that satisfaction of being “empty”, however I feel very lethargic and just exhausted and start to procrastinate and become somewhat lazy. I also sometimes feel a little stressed afterwards too. I feel...
  5. haidut

    Intense exercise causes mitochondrial damage even in elite athletes

    Hopefully, this post won't be interpreted as trying to bash exercise. Its goal is to simply draw attention to the fact that intense exercise can be detrimental even for elite athletes. While the damage the study observed was temporary, it is now known that (just like ionizing radiation) the...
  6. skuabird

    Skua's Weightloss and Health Problems Log

    7/18/2021: 252lb 5’9”, F, 34 Current/recent Problems: Blurred vision with subtle headaches sometimes becoming migraines in evening, especially during middle of menstrual cycle Feel like my blood sugar is all over, especially after high protein meal Severe fatigue, worse after any activity...
  7. S

    Kiwi modulates my secondary narcolepsy and hypogonadism symptoms

    All my life I have struggled with sleep attacks during the day. Going Peaty helped me avoid these attacks during the day (making me employable), but in the afternoon and evening they occur at least once. They occur enough that I really can't get involved with things outside of family...
  8. RealNeat

    Long hours driving for job. Mitigation of harm?

    I have started a job where I spend a lot of hours sitting in a car. I try to keep as much of the tech in there on airplane mode as I can to avoid the faraday effect of RF in a metal car. I'm trying to better my posture as it gets forward leaning throughout the day and I generally feel tight...
  9. M

    How Do You Feel When You Wake Up?

    How do you feel when you wake up in the morning? How do you think you should feel when you wake up? What factors do you think are influencing this, other than poor quality sleep? Note: in my low carb days, I often woke up feeling alert and refreshed, but it was suggested to me that this was...
  10. D

    High Pulse, Low Morning Temperature

    Hey I'm 24 year old male I've been struggling with fatigue and irritability/depression/lack of good libido with gut issues (and recently hemmorhoids/yellowish stools) on and off for pretty much all my life sometimes better sometimes worse, I recently came back to peating which I've struggled to...
  11. JazTee

    Ehlers-Danlos Syndrome Help?

    Hi all, I recently posted a thread here: (Feeling Terrible at 22) where I basically listed all my symptoms and recieved some amazing advice for my metabolism, overall dietary health etc. I suggest reading this post first to get an insight into my lifestyle and health. (TL-DR; I basically...
  12. haidut

    Pregnenolone (P5) May Be Ergogenic And Helps Recovery From Exercise

    Take this study with a grain of salt simply because the only link to it is from a scientific conference, which means the study is not yet published in peer-reviewed journals. Yet, the results it reports are quite interesting. Namely, a single 100mg pregnenolone (P5) dose accelerated recovery...
  13. haidut

    Children Have More Energy And Recover Faster Than Elite Endurance Athletes

    While endurance exercise is hardly the healthiest form of physical activity, triathlon runners are known for their ability to quickly clear lactate out of the blood and metabolite it back into glucose. The ability to handle lactate is good metric of metabolic health and the pyruvate/lactate...
  14. P

    Low Carb Diet,FFAs, High Free Tryptophan, Serotonin ,fatigue

    Also the question of "does a high fat meal increase free fatty acid levels?" The answer is yes!it does. Low-Carbohydrate-High-Fat Diet: Can it Help Exercise Performance? Low-carbohydrate-high-fat (LCHF) diets have been used as a means of weight loss and control of symptoms in several...
  15. P

    Low Carb Diet , Glycogen Level, Performance,metabolic Rate

    Low carbohydrate diet induces metabolic depression: a possible mechanism to conserve glycogen. - PubMed - NCBI Long-term studies have found low carbohydrate diets are more effective for weight loss than calorie restricted diets in the short-term, but equally or only marginally more effective...
  16. Giraffe

    TSH (Thyroid Stimulating Hormone) Reference Range Wars

    I highly recommend reading the full article, there is a lot of information and advice on that site. Some excerpts: What is a reference range? Changing the reference range. The two sides of the public debate ...... Wartofsky & Dickey, "Controversy in Clinical Endocrinology: The...
  17. haidut

    Self-reported Health Much Better Predictor Than "objective" Tests

    I like this study for a number of reasons. First, it validates the idea that the patient knows quite well when something is plaguing them despite the current approach to ignore completely self-reported symptoms. Second, it confirms the connection between stress and inflammation, and viral...
  18. Mr Rossi

    Thiamine And Fatigue In Inflammatory Bowel Diseases

    Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study. - PubMed - NCBI whole study: An Error Occurred Setting Your User Cookie
  19. Mr Rossi

    Studies: High-dose Thiamine Improves Fibromyalgia & Fatigue Symptoms + Own Experiment!

    High-dose thiamine improves the symptoms of fibromyalgia. - PubMed - NCBI High dose thiamine improves fatigue in multiple sclerosis. - PubMed - NCBI Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study. - PubMed - NCBI High-dose thiamine improves fatigue after...
  20. haidut

    Lowering Sertonin In The Brain Abolishes Fatigue

    There have been many studies on this, and in fact my experiments with BCAA and tyrosine to reduce serotonin in the brain were based on those studies. This study however, goes a step further and claims that exercise-derived (but probably any other as well) fatigue is fully abolished by inhibiting...