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oxphos

  1. haidut

    Fasting causes aging by energy depletion, vitamin B2 can stop it

    Well, if this title does not rile up the fasting crowd, I don't know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes...
    • haidut
    • Thread
    • aging ampk fad fasting oxphos riboflavin senescence senolytic stress vitamin b2
    • Replies: 36
    • Forum: Scientific Studies
  2. haidut

    Cancer cells deprive immune cells of energy by devouring their mitochondria

    In a description that could be a good plot for a horror-movie, the study below demonstrates that the immune failure often seen in cancer is, again, bioenergetic in origin. More specifically, the immune system cells are getting literally the energy (i.e. mitochondria) sucked out of them by cancer...
    • haidut
    • Thread
    • cancer cell endotoxin estrogen immune invadopodia lps mitochondria oxphos phagocytosis
    • Replies: 1
    • Forum: Scientific Studies
  3. haidut

    Uncoupling metabolism/OXPHOS may treat inflammatory conditions

    In several of his articles and interviews, Peat mentioned that one of the reliable signs/symptoms of low metabolism is the presence of low-grade chronic inflammation. Basically, the cell is stuck into a constant (and futile) repair process as it cannot complete it properly after discovering the...
    • haidut
    • Thread
    • atpase inflammation metabolism mitochondria oxphos ros uncoupling
    • Replies: 4
    • Forum: Scientific Studies
  4. haidut

    Restoring oxidative metabolism has curative effects on cancer (leukemia)

    A great study, which directly demonstrates not only the OXPHOS deficiency characteristic of all "cancer" cells, but also proving that restoration of OXPHOS is highly therapeutic (and likely curative) for leukemia. Just as importantly, the study demonstrates that cancer cells have, in fact...
  5. haidut

    Cartilage/bone health depends on oxidative metabolism

    A good study that demonstrates yet another "structural" aspect of health - the strength and growth or our cartilage/bones - is heavily dependent on proper mitochondrial function. As such, even minor disruptions of oxidative metabolism can lead to long-term deformations in bone/cartilage, which...
  6. haidut

    Infrared/red light applied to the skull can treat Alzheimer's/dementia...

    ...and improve cognition even in healthy people! The mechanism of action is the familiar effects of red/infrared light on stimulating mitochondrial function, and especially complex IV, while also decreasing chronic inflammation. The regimen was light exposure for 6min, twice a day, for 4 weeks...
    • haidut
    • Thread
    • alzheimer atp dementia infrared mitochondria oxphos red light
    • Replies: 10
    • Forum: Scientific Studies
  7. haidut

    Damaged mitochondria may cause 90%+ of Parkinson Disease (PD) cases

    More evidence that yet another "incurable" condition is little more than energy deficit (due to mitochondrial dysfunction) in disguise. In this case the mitochondrial dysfunction was caused by accumulation of mitochondrial debris inside the cell, which has been repeatedly shown by other studies...
    • haidut
    • Thread
    • damage dementia metabolism mitochondria oxphos parkinson stress
    • Replies: 4
    • Forum: Scientific Studies
  8. haidut

    Aging is an energy deficiency problem, taking cardiolipin may reverse it

    Yet another study demonstrating that "aging" is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a...
    • haidut
    • Thread
    • aging cardiolipin disease energy lifespan metabolism mitochondria oxphos
    • Replies: 8
    • Forum: Scientific Studies
  9. haidut

    COVID-19 is an energy deficiency disease

    Yet another seemingly non-metabolic disease turns out to be nothing but energy deficiency in disguise. Apparently, the SARS-CoV-2 virus selectively disables so-called complex I of the electron transport chain (ETC), and as such the overall OXPHOS process. Such inhibition is known to reliably...
    • haidut
    • Thread
    • complex i covid-19 electron transport chain energy etc mitochondria oxphos sars-cov-2
    • Replies: 4
    • Forum: Scientific Studies
  10. haidut

    Loss of mitochondrial function (OXPHOS) induces de-differentiation (cancer)

    The study only focuses on the lymphatic system and its cells, but the principle is general and has been observed in other organ/tissue cells. The most obvious example is cancer - no matter which organ it occurs in, the tumor is composed of de-differentiated cells not unlike the stem cells from...
    • haidut
    • Thread
    • cancer differentiation electron transport chain etc loss metabolism mitochondria oxphos
    • Replies: 0
    • Forum: Scientific Studies
  11. haidut

    Muscle weakness / wasting linked to poor mitochondrial function

    A study that once again illustrates the central principle of bioenergetics - structure and function cannot be separated. They are interdependent at every level. In this specific case, the "structural" pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when...
    • haidut
    • Thread
    • atp atrophy cachexia metabolism mitochondria muscle weakness oxphos sarcopenia
    • Replies: 0
    • Forum: Scientific Studies
  12. haidut

    Vitamin D deficiency impairs muscles by lowering energy production

    Perhaps this study below will put some of the arguments against vitamin D supplementation to rest. It demonstrated up to 40% reduction of energy production in the muscles of animals deficient in vitamin D, in spite of unchanged number/size/density of mitochondria inside the cells. In addition...
    • haidut
    • Thread
    • cholecalciferol energy mitochondria muscle oxphos sarcopenia vitamin d vitamin d3
    • Replies: 2
    • Forum: Scientific Studies
  13. haidut

    Inhibiting respiration/metabolism reliably causes bipolar disorder

    Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport...
    • haidut
    • Thread
    • bipolar disorder depression etc mania metabolism mitochondria oxphos
    • Replies: 0
    • Forum: Scientific Studies
  14. haidut

    Reduced pyruvate and/or increased lactate drive heart failure

    I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of...
    • haidut
    • Thread
    • energy heart failure lactate lactic acid metabolism oxphos pyruvate
    • Replies: 0
    • Forum: Scientific Studies
  15. haidut

    Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide

    About a year ago, a publication came out that demonstrated therapeutic effects of raising the (mitochondrial) NAD/NADH ratio in glaucoma patients. That study used niacinamide (NAM) and suggested that the "irreversible" changes in eye structure seen in glaucoma patients are in fact nothing more...
    • haidut
    • Thread
    • energy eye glaucoma niacinamide oxphos pyrucet pyruvate
    • Replies: 2
    • Forum: Scientific Studies
  16. haidut

    Niacinamide may treat ALS by improving energetic state

    Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...
    • haidut
    • Thread
    • als atp glycolysis lactate niacinamide nicotinamide oxphos vitamin b3 warburg
    • Replies: 0
    • Forum: Scientific Studies
  17. haidut

    Low, Not High, Metabolism Creates Oxidative Stress

    A hugely popular tenet of the "rate of living" theory is that the higher the metabolic rate the more reactive oxygen species (ROS) an organism produces. ROS elevation has already been implicated in a host of chronic disease including diabetes, CVD, cancer, neurological conditions and even mental...
    • haidut
    • Thread
    • electron acceptor metabolism oxidation oxidative stress oxphos redox reduction ros
    • Replies: 6
    • Forum: Scientific Studies
  18. haidut

    Low Metabolism, Cellular Debris May Cause Huntington Disease (HD)

    Yet another study demonstrating the crucial role of oxidative metabolism (OXPHOS) in a chronic degenerative condition considered largely genetic in origin. Just as importantly, the study corroborates findings from other recent reports/experiments demonstrating that the presence of cellular...
    • haidut
    • Thread
    • debris huntington inflammation metabolism mitochondria oxphos stress thiamine
    • Replies: 0
    • Forum: Scientific Studies
  19. haidut

    Exposure To Fluoride Actually Damages Teeth, Even At Low Concentrations

    Most adults are familiar with the much-publicized (and advertised) claims of public health authorities about the purported benefits of fluoride exposure for dental health. The official story is that by adding fluoride to tap water, people's teeth are exposed to "low" concentration of fluoride...
    • haidut
    • Thread
    • cause damage dental dental fluorosis dysfunction enamel fluoride mitochondria oxphos
    • Replies: 3
    • Forum: Scientific Studies
  20. haidut

    Simple Heating Of Tumor Often Leads To A Rapid And Complete Cure

    As many readers of my blog know, one of the primary signs/symptoms in cancer patients is the frequent occurrence of fevers. The official position of mainstream medicine is that the cause of these fevers is unknown but may have to do with the so-called "tumor lysis syndrome". Regardless, the...
    • haidut
    • Thread
    • cancer cure heat hyperthermia mb methylene blue oxphos red light uncoupling
    • Replies: 23
    • Forum: Scientific Studies
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