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oxphos

  1. haidut

    Harvard Psychiatrist: All Mental Disease is Metabolic/Bioenergetic Disease

    It is always nice to see mainstream medicine plagiarize from Dr. Peat attempt to right its course after decades-long mistakes. While the genetic dogma still rules supreme in medicine's attitude towards most "physical" diseases, the utter failure of the "serotonin hypothesis" and its dear...
  2. EnergeticLeo

    Nice video on the electron transport chain!

    View: https://www.youtube.com/watch?v=UyTto4Aegss Really enjoyed this video - there were some holes in my understanding that I wanted to fill up. I'm sure it's not perfect, but I still found it useful.
  3. haidut

    Diabetes, Alzheimer's, cancer are bioenergetic diseases; PUFA may be the cause

    The bad news for PUFA (in this case linoleic acid) just keep piling on. At this point, there is hardly a chronic condition out there that has not been linked to elevated PUFA and/or their peroxidation products. The first study below makes the argument that PUFA peroxidation byproducts (created...
  4. haidut

    Impaired OXPHOS by high ketones drives heart failure

    Just a few weeks after my post on how excessive fatty acid oxidation (FAO) drives cancer, below is another great new study, which corroborates once again the hypothesis that excessive FAO (and/or fatty acid supply into the mitochondria of the cell) result in impaired OXPHOS and organ damage...
  5. haidut

    Disrupting mitochondrial function can cause severe anemia

    Most doctors consider anemia mostly an iron-related issue, despite the fact that iron supplementation often fails to correct the condition, even in people with true iron deficiency anemia (e.g. low iron saturation index, low ferritin, high transferin). The role of bioenergetics is rarely...
  6. B

    Doxycycline Impairs Cardiac Mitochondrial and Contractile Function

    Mice treated with doxycycline showed mitochondrial complex I dysfunction, reduced OXPHOS capacity and impaired diastolic function. Doxycycline exacerbated diastolic dysfunction and reduced ejection fraction in a diabetes mouse model vulnerable for metabolic derangements. We therefore conclude...
  7. haidut

    Cancer relies on fat as fuel due to high reductive stress

    One of the few studies out there that not only links cancer with impaired OXPHOS, but demonstrates directly the role of reductive stress (exemplified by the NAD/NADH ratio) in cancer's appetite for fats as fuel required for the cancer survival and proliferation/metastasis. It also once again...
  8. haidut

    No evidence for rate-of-living theory of aging

    Just a quick post, since this topic dominates anti-aging research - i.e. despite lack of concrete evidence for it, mainstream research (and finding agencies) continue to claim that longevity is tied to metabolism, but in an inverse relationship. The study below is on turtles - one of the longest...
  9. haidut

    Reductive stress drives pathogenesis and progression of tuberculosis

    I am posting this study b/c it is one of the few I have seen lately demonstrating that even infectious diseases are metabolic in origin. Of course, a pathogen is involved as well, but as it turns out it may not be able to cause an infection by itself. For that to happen, a metabolic dysfunction...
  10. haidut

    Vitamin B1 as a potential treatment for Alzheimer's Disease (AD)

    After decades of denial that AD is a metabolic condition, Big Pharma and Big Govt, are silently doing an 180-degree turn by secretly funding university clinical trials for metabolic interventions in that disease. The study below will evaluate the effects of benfotiamine - a lipophilic analog of...
  11. haidut

    BOMBSHELL: Serotonin High in Depression, Not a "Happy" Chemical, Lowers Energy, Depression Self-Resolves

    When I first saw the article pop up in my feed, I could hardly believe my eyes that a mainstream mouthpiece of Big Pharma will publish such frank admission of psychiatry's utter failure - i.e. the claims in regards to serotonin (5-HT), its role in mental illness, and even its social "label". In...
  12. haidut

    Low-dose niacinamide has striking anti-obesity effects

    It looks like the medical world has firmly set its sights on the bioenergetic wave/target, as the number of scientific papers focusing on niacinamide, NAD/NADH ratio and OXPHOS in general has been steadily climbing since 2010. That would be good news, despite the attempts of companies such as...
  13. haidut

    Hypogonadism in older males due to low OXPHOS

    I suspect many readers will simply say "duh!", but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the...
  14. haidut

    Stem cells availability, and their differentiation, depend on metabolism

    Once again, the master controller role metabolism plays in human life is revealed in yet another experiment. The study below demonstrated that the degree of cell "stemness", as well as its differentiation into a specific organ/tissue depends entirely on the metabolic rate of the cell, and thus...
  15. haidut

    PUFA cause obesity, diabetes, autism, Alzheimer's disease, anxiety, and depression

    The title is an actual quote from the article, so there is no editorializing on my part and it speaks volumes about how the authors feel about their findings. In addition, opposite effects were found for saturated fats, in this case coconut oil, which leads the authors to once again remind...
  16. haidut

    Epilepsy/seizures caused by energetic deficit leading to calcium overload

    Yet another study demonstrating that not only is a chronic, "incurable" disease of unknown origin treatable but that its main cause is energetic/metabolic and linked to impaired glucose metabolism. Specifically, the study demonstrated that impaired pyruvate transport into the mitochondria is...
  17. haidut

    Aging and disease are the same process, driven by low metabolism

    I am posting about this mostly due to its "told you so" factor - i.e. more and more professionals in the medical and research fields are starting to realize that the super-specialized approach to treating chronic diseases has not produced any substantial results. In addition, the correlation...
  18. haidut

    Pfizer COVID-19 vaccine inhibits OXPHOS, may cause/promote aggressive cancer

    Another "shocking" study about COVID-19 vaccines. Spoiler alert - the claims that they cause cancer may very well be true and the mechanism of action may be metabolic. The study below demonstrated that within 4 days of cell exposure to the Pfizer vaccine solution (containing mRNA), there was a...
  19. haidut

    Fasting causes aging by energy depletion, vitamin B2 can stop it

    Well, if this title does not rile up the fasting crowd, I don't know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes...
  20. haidut

    Cancer cells deprive immune cells of energy by devouring their mitochondria

    In a description that could be a good plot for a horror-movie, the study below demonstrates that the immune failure often seen in cancer is, again, bioenergetic in origin. More specifically, the immune system cells are getting literally the energy (i.e. mitochondria) sucked out of them by cancer...
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