oxphos

  1. haidut

    A single 15min exposure to red light boosts mitochondria and lowers blood glucose

    A human study, which makes it that much more important. While the findings are not very surprising, what is important to take from the study is that 1) elevated blood glucose is likely a good biomarker of poor mitochondrial function, 2) exposure to just 15min of red light daily can lower blood...
    • haidut
    • Thread
    • atp diabetes glucose glycogen mitochondria oxphos red light
    • Replies: 8
    • Forum: Scientific Studies
  2. haidut

    Niacinamide may treat Parkinson Disease (PD)

    A very interesting study, which used a relatively high dose of nicotinamide riboside (NR) to treat Parkinson Disease (PD). The dosage used was 3,000mg daily for 4 weeks and it resulted in improvement of motor and cognitive symptoms of PD, while producing no side effects. The study references...
    • haidut
    • Thread
    • metabolism nad nad/nadh niacinamide nicotinamide riboside oxphos parkinson vitamin b3
    • Replies: 9
    • Forum: Scientific Studies
  3. haidut

    Multiple sclerosis (MS) may be due to low metabolism / glucose oxidation

    Nothing surprising in the findings of the study, and in fact a great corroboration of the results from the high-dose biotin human study with the aggressive form of MS published several years ago. The officially proposed mechanism of biotin in that study was improved glucose oxidation...
    • haidut
    • Thread
    • energy fatigue glucose metabolism ms multiple sclerosis oxphos oxygen consumption
    • Replies: 6
    • Forum: Scientific Studies
  4. haidut

    Adolescent stress causes mental illness, cognitive issues by lowering metabolism

    It has long been known that pre-natal stress (e.g. stressed of the mother during pregnancy), as well as chronic stress after birth are associated with high risk of mental illness, criminal behavior, substance abuse, reduced cognitive function, chronic illness, and even early death. However, the...
    • haidut
    • Thread
    • cognition energy mental illness metabolism mitochondria oxphos respiration stress
    • Replies: 3
    • Forum: Scientific Studies
  5. haidut

    LipOdd - Liquid Product With Odd-Chain Saturated Fats (SFA)

    More than a decade ago, when I was just beginning my exploration of bioenergetics, one of the first indications that Ray's writings were onto something when it came to SFA vs. PUFA was the fact that while mainstream medicine ruthlessly bashed SFA in general and promoted PUFA, virtually very...
    • haidut
    • Thread
    • aging anemia antibacterial autoimmune cancer cvd depression diabetes fibrosis heptadecanoic inflammation lifespan lipodd metabolism mitochondria neurodegeneration obesity oxphos pentadecanoic sfa
    • Replies: 93
    • Forum: IdeaLabs
  6. haidut

    How adrenochrome works - it is a potent oxidizer/quinone and serotonin antagonist

    As most of my readers know, the topic of adrenochrome is perhaps one of the most controversial in both politics and medicine, due to its purported harvesting from children and usage for anti-aging purposes, as well as due to its purported role in causing schizophrenia and a number of other...
    • haidut
    • Thread
    • 5-ht adrenochrome aging lifespan metabolism oxphos quinone serotonin
    • Replies: 27
    • Forum: Scientific Studies
  7. haidut

    Blocking prostaglandins restores (glucose) metabolism, reverses brain aging

    It is rare to find a study like the one below that combines so many crucial topics into a unified message. Namely, the role of energy in aging and disease, the role of oxidative glucose metabolism in aging and health, the pathological role of PUFA as a negative (glucose) metabolic regulator and...
    • haidut
    • Thread
    • aging brain cognition glucose inflammation oxphos pge2 prostaglandin pufa
    • Replies: 15
    • Forum: Scientific Studies
  8. haidut

    Reduced availability/oxidation of glucose sufficient to cause heart failure (HF)

    Yet another "mysterious" idiopathic condition turns out to be nothing but metabolic dysregulation in disguise. Also, unlike many other studies implicating metabolism in disease, this one actually manages to demonstrate that reduction of oxidative glucose metabolism is sufficient to cause severe...
    • haidut
    • Thread
    • glucose heart failure lactate ldh mitochondria oxphos pyruvate
    • Replies: 1
    • Forum: Scientific Studies
  9. haidut

    Inhibiting oxidative metabolism can cause inflammation, aggressive cancer

    Despite medicine's rabid defense of the "cancerous mutation" origin theory of cancer, it looks like evidence for the metabolic origins of cancer has always been around and hiding in "plain sight". The study below cites the apparently well-known causal link between accumulation of fumarate (a...
    • haidut
    • Thread
    • autoimmune cancer citric fumarate inflammation krebs mitochondria oxphos
    • Replies: 0
    • Forum: Scientific Studies
  10. haidut

    Restoring mitochondrial function reverses aging in blood/immune cells

    The number of studies focusing on bioenergetics as a reliable method for delaying (or even reversing) aging continues to rapidly grow. A few years ago, an in-vivo study with humans demonstrated that human immune system aging can be reversed by a combination of DHEA and a few other, less...
    • haidut
    • Thread
    • aging bioenergetics immune metabolicm mitochondria mitophagy oxphos
    • Replies: 2
    • Forum: Scientific Studies
  11. haidut

    Stress/Injury (mitochondrial dysfunction) sufficient to cause de-differentiation, even cancer

    One of the most pernicious myths in medicine is the "irreversibility" of several cellular processes related to aging, diabetes, fibrosis and, of course, cancer. Perhaps the most fundamental of those processes is cellular differentiation. To this day, the dominant opinion in medicine is that once...
    • haidut
    • Thread
    • cancer differentiation electron flow etc mitochondria oxphos reactive oxygen species ros
    • Replies: 2
    • Forum: Scientific Studies
  12. haidut

    Human trial - niacinamide may treat Alzheimer Disease (AD)

    One of my first posts on the topic of bioenergetics - more than a decade ago - was in regards to a promising animal study with the human-equivalent dose (HED) of 30mg/kg niacinamide (NAM) daily showing robust effects on that animal species' model of AD. The authors of the animal study followed...
    • haidut
    • Thread
    • alzheimer dementia nad niacinamide nicotinamide oxphos
    • Replies: 8
    • Forum: Scientific Studies
  13. haidut

    Vitamin B1 (thiamine) may treat Amyotrophic Lateral Sclerosis (ALS)

    A human case study, corroborated by the literature review done by the authors, suggesting that yet another degenerative and invariably lethal condition may be nothing more than energetic deficiency in disguise. The literature review the authors performed revealed that ALS patients, as well as...
    • haidut
    • Thread
    • als atp benfotiamine glucose neurodegenerative oxphos thiamine vitamin b1
    • Replies: 6
    • Forum: Scientific Studies
  14. haidut

    Fasting/exercise/lowcarb/keto may promote cancer (melanoma) metastasis

    Quite the title for this post, but I think the evidence from the study below is clear. Namely, chronic activation of the so-called "master metabolic sensor" AMPK is a key mechanism through which melanoma cells rewire their metabolism from higher into lower OXPHOS, change their physical structure...
    • haidut
    • Thread
    • ampk cancer exercise fao fasting fission lowcarb melanoma metastasis mitochondria oxphos paleo
    • Replies: 29
    • Forum: Scientific Studies
  15. haidut

    Media: Endotoxin (LPS) drives obesity/diabetes

    I did not think we will ever see such a headline in a major news outlet, but here is is. And in The Guardian of all places, which is a newspaper that rarely deviates from the official medical narrative on any condition, especially obesity and diabetes. The official narrative for those conditions...
    • haidut
    • Thread
    • diabetes endotoxin inflammation lps metabolism obesity oxphos pufa
    • Replies: 9
    • Forum: Scientific Studies
  16. haidut

    NAD+ deficiency causes kidney disease, niacinamide prevents it

    Chronic kidney disease (CKD) is one of the most prevalent complications of obesity and diabetes. Its causes, as usual, are "unknown" according to mainstream medicine but high glucose levels and genetic predisposition are thought to play a role. Many studies have called into question these...
  17. haidut

    Regaining weight post diet/exercise due to lowered metabolism by increased PUFA in cardiolipin

    This is by far the most significant study I have seen come out in the last 2-3 years, simply because of the impact it has on virtually every person out there who has tried to lose excess weight (and who hasn't?). Virtually every person considering (or having done) dieting/exercise to lose excess...
    • haidut
    • Thread
    • cardiolipin diet exercise fasting metabolism obesity oxphos pufa
    • Replies: 117
    • Forum: Scientific Studies
  18. haidut

    Niacinamide/NAD+ may prevent heart failure

    The rates of cardiovascular disease (CVD) continue to rise and the condition is still the top killer in developed countries, though it is likely that cancer will take the top spot in the next few years and CVD will move back to second place. Heart failure (HF) is one of the common outcomes of...
    • haidut
    • Thread
    • fibrosis heart failure nad niacinamide nicotinamide oxphos
    • Replies: 0
    • Forum: Scientific Studies
  19. haidut

    Metabolic rate may determine personality type and disease risk

    Very interesting study that links mitochondrial density/number (and as such, the metabolic rate) with personality types. Namely, people with fewer mitochondrial (i.e. hypometabolic) tend to have high levels of neuroticism, with the latter causally linked to a higher risk of a number of serious...
    • haidut
    • Thread
    • atp bioenergetics metabolism mitochondria neuroticism oxphos personality
    • Replies: 4
    • Forum: Scientific Studies
  20. haidut

    Restoring mitochondrial function may be sufficient to reverse aging

    The findings of the study may not sound very novel to my readers, however please keep in mind that the vast majority of anti-aging studies so far have only looked at slowing (not even stopping) aging. Actually reversing aging is the Holy Grail of gerontology, and to date very few studies have...
    • haidut
    • Thread
    • aging energy lifespan metabolism mitochondria oxphos polarization
    • Replies: 6
    • Forum: Scientific Studies
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