haidut

Member
Joined
Mar 18, 2013
Messages
18,032
Location
USA / Europe
Peat has mentioned the Creutzfeldt-Jacob disease (CJD) / BSE in several of his articles and interviews and has explained how environmental stress, estrogen, PUFA, ionizing radiation, etc can cause metabolic derangements resulting in the same brain damage so characteristic of this pathology. The public is more familiar with that pathology under the name of mad cow disease (MCD) and it seems virtually every country in the world with large beef-producing industry is periodically hit by a wave of this pathology. What makes MCD relevant to humans is that it can actually cause the same disease in humans by virtue of consuming meat from animals inflicted by CJD/BSE. The official version is that the cause of the disease is unknown but it results in misfolded proteins that acquire infectious properties and can cause the same deformities in the brains of people who eat contaminated meat. How exactly small proteins not carrying genes (unlike, say, viruses) are capable of becoming infectious continues to baffle mainstream medicine. Some mainstream geneticists have proposed that the disease is caused by so-called "slow viruses", yet not such viruses have been found so far. As usual, the answer may be something much simpler and more fundamental. Namely, as the study below demonstrates, the CJD/BSE/MCD pathology may be simply a symptom/sign of mitochondrial failure. More importantly, the study is one of the few that states proper energy production is required for maintenance of a cell's structure (and not just function). As such, this disease may very well be treatable by interventions that improve mitochondrial function and shift the metabolism away from the oxidation of fat and towards the oxidation of glucose. That same approach has already been shown to be therapeutic in other neurodegenerative conditions such as multiple sclerosis (MS) and even the invariably lethal amyotrophic lateral sclerosis (ALS). I don't see a reason why it won't also work in CJD/BSE/MCD.

Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease
https://medicalxpress.com/news/2020-05-brain-powerhouses-creutzfeldt-jacob-disease.html

"...A study performed by researchers from the University of Bergen, Norway, and the University of Vienna, Austria, shows damage of the mitochondria—the cell's microscopic powerhouses—in the brains of people with Creutzfeldt-Jacob disease. The researchers found that the mitochondrial power generator (known as the respiratory chain) is severely impaired in brain cells from people who died with Creutzfeldt-Jacob disease. "These mitochondrial defects were widespread in the brain and correlated with the severity of disease," says Professor Charalampos Tzoulis at the University of Bergen and Haukeland University Hospital, Bergen. Damaged mitochondria are no longer able to provide the energy required for neuronal maintenance and function. "These findings strongly suggest that mitochondrial failure contributes to the pathogenesis of Creutzfeldt-Jacob disease," says Tzoulis."
 
Joined
Dec 18, 2018
Messages
2,207
Very interesting.I also came along the notion that Prionprotein itself,eufolded or misfolded, is related to Thiamine metabolism, hence parts of energymetabolism,B1s trafficking,allocation and other state of affairs and relations.
 

Eberhardt

Member
Joined
Apr 28, 2019
Messages
374
Hi. this is very interesting indeed. I have a question though. If this is true - which I have been leaning towards for a while - then how come it spreads in wild population. For example there have been outbrakes of prion disease in wild reindeer populations without any observable artificial trigger like say a radiation leak or similar. I assume the mitochondrial state of otherwise healthy animals to be fairly good so how does this happen then? @haidut ?
 

Perry Staltic

Member
Joined
Dec 14, 2020
Messages
1,988
Hi. this is very interesting indeed. I have a question though. If this is true - which I have been leaning towards for a while - then how come it spreads in wild population. For example there have been outbrakes of prion disease in wild reindeer populations without any observable artificial trigger like say a radiation leak or similar. I assume the mitochondrial state of otherwise healthy animals to be fairly good so how does this happen then? @haidut ?

It's been a while since I looked at it, but Mark Purdy's research revealed either high manganese soils, or local hunters using high manganese licks to make deer antlers grow larger in areas with clusters of deer wasting disease. He hypothesized that high manganese cattle feeds and use of the organophosphate pesticide Phosmet caused manganese poisoning that deformed prions. Dr. David Brown of Cambridge proved that manganese can deform prions exactly as observed in Mad Cow disease.

 

RealNeat

Member
Joined
Jan 9, 2019
Messages
1,260
Location
Minnesota
It's been a while since I looked at it, but Mark Purdy's research revealed either high manganese soils, or local hunters using high manganese licks to make deer antlers grow larger in areas with clusters of deer wasting disease. He hypothesized that high manganese cattle feeds and use of the organophosphate pesticide Phosmet caused manganese poisoning that deformed prions. Dr. David Brown of Cambridge proved that manganese can deform prions exactly as observed in Mad Cow disease.

Interesting, there is some major CWD phobia around these parts but no one ever ties it to environmental exposure and once again just attributes it to a contagious disease (easy cop out without need of critical thought)

they feed them garbage and the deer eat higher PUFA foods especially when they are baited. They also munch all over sprayed greens and side of the road exposing themselves to break dust residue and the like...

it's telling when the most CWD is in and around the cities and not where I live (super rural)
 

Eberhardt

Member
Joined
Apr 28, 2019
Messages
374
Interesting, there is some major CWD phobia around these parts but no one ever ties it to environmental exposure and once again just attributes it to a contagious disease (easy cop out without need of critical thought)

they feed them garbage and the deer eat higher PUFA foods especially when they are baited. They also munch all over sprayed greens and side of the road exposing themselves to break dust residue and the like...

it's telling when the most CWD is in and around the cities and not where I live (super rural)
Also @Perry Staltic . I actually wrote to peat about it and he said that it fitted quite well with the delayed and not to forget accumulated effect of the chernobyl fallout. There's no baiting in Norway as far as I know but maybe it can affect it too. So far the only verified once of prion diseases have been connectable to radiation
 

tygreezytlb

Member
Joined
Jul 23, 2020
Messages
48
How then I'm curious does this explain lab leaks where someone is directly exposed to prions and then develops the disease 9 years later.

It clearly is an infectious protein
 

Eberhardt

Member
Joined
Apr 28, 2019
Messages
374
How then I'm curious does this explain lab leaks where someone is directly exposed to prions and then develops the disease 9 years later.

It clearly is an infectious protein
I have never heard of this, do you have any sources?
 

Perry Staltic

Member
Joined
Dec 14, 2020
Messages
1,988
How then I'm curious does this explain lab leaks where someone is directly exposed to prions and then develops the disease 9 years later.

It clearly is an infectious protein

Can you provide an example? Sounds dubious.
Edit: n/m, I see post above
 

Perry Staltic

Member
Joined
Dec 14, 2020
Messages
1,988


Pure conjecture. Not credible evidence of infectious protein, i.e., prion.
 

tygreezytlb

Member
Joined
Jul 23, 2020
Messages
48
Pure conjecture. Not credible evidence of infectious protein, i.e., prion.

How so? Come on the coincidence level is pretty ridiculous. She works in a lab stabs herself with prions and gets CJD. What else would it be?! Your not really offering any better explanation.
 

Perry Staltic

Member
Joined
Dec 14, 2020
Messages
1,988
How so? Come on the coincidence level is pretty ridiculous. She works in a lab stabs herself with prions and gets CJD. What else would it be?! Your not really offering any better explanation.

Nine years elapsed. Could have been anything. Correlation, especially that weak, does not equal causation. Just because I don't have other explantions doesn't make the prion hypothesis more credible. There really is no compelling evidence that prions are infectious; just weak correlations like this
 

Jon2547

Member
Joined
Mar 2, 2021
Messages
537
How then I'm curious does this explain lab leaks where someone is directly exposed to prions and then develops the disease 9 years later.

It clearly is an infectious protein
No its not "clearly" an infectious protein.
 

Jon2547

Member
Joined
Mar 2, 2021
Messages
537
When we have discussions with those that believe in contagious pathogens that float thru the air and land on organisms causing apocalyptic plagues, the issue is not really the so-called micro organism. The real issue is the mind of the befuddle that believes such a thing. If you're not inferring arrogance from this, chances are, you are one of those that believes in such mythology.

I don't know how David Copperfield made the Statue of Liberty disappear into thin air. But just because I can't explain how he pulled off this illusion does not mean that the Statue of Liberty was made to vanish literally.
 

tygreezytlb

Member
Joined
Jul 23, 2020
Messages
48
I fear ur not honestly looking at this. Seems to be a confirmation bias. Im in agreement with how much of a role cellular integrity has so to speak but clearly these prions have an affect on the human body. To say otherwise without offering any alternative theory is pretty poor. If it were not a case of infection we would see far more cases of prion illness.

I'm going where the evidence leads you seemingly are denying the evidence. That is far too much of a coincidence in my opinion.
 

Perry Staltic

Member
Joined
Dec 14, 2020
Messages
1,988
I fear ur not honestly looking at this. Seems to be a confirmation bias. Im in agreement with how much of a role cellular integrity has so to speak but clearly these prions have an affect on the human body. To say otherwise without offering any alternative theory is pretty poor. If it were not a case of infection we would see far more cases of prion illness.

I'm going where the evidence leads you seemingly are denying the evidence. That is far too much of a coincidence in my opinion.

There is no quality evidence; just circumstantial. An alternative theory is manganese poisoning. Much more credible. They can't reproduce the same protein misfolding blamed on prions in animals fed tissues from animals that had "prion disease", but Dr. David Brown of Cambridge did reproduce exactly the same misfolding by exposing brain tissue to manganese. That's quality evidence. Research Mark Purdy + manganese.
 

tygreezytlb

Member
Joined
Jul 23, 2020
Messages
48
Okay well next question would be what are some implementations that would help fight this disease at all ? If any ? I see the article talks about mitochondria what in particular could one actually do.
 
Similar threads
Thread starter Title Forum Replies Date
T Took Grass fed brain capsules, Neurological symptoms still a week after stopping (Mad Cow!?) Ask For Help or Advice 45
charlie BSE - Mad Cow - Scrapie, Etc. Stimulated Amyloid. Articles & Newsletters 2
A You Know You've Gone Peat Mad When Health 156
P 'Mad Fruit' - Indeed Fruits 4
Apollo Cow's milk interferes with absorption of thyroid supplement levothyroxine Thyroid and Hormones 2
G When can babies have cow's or goats milk as main form of calories? Diet 21
Mito Microbe that can break down plastic discovered in cow's stomach Miscellaneous Health Discussions 2
Apollo 1 Liter Of Cow Milk At Once in the morning Ok ? hypercalcemia ? Milk 39
H I am lactose intolerant - Goat's Milk, Cow's Milk, Sheep's Milk & Casein. What now? Digestion 29
Geronimo I Want Cow Balls Male Issues 7
A Here Is How To Drink 1 Liter Of Cow Milk At Once Without Feeling Cold Milk 19
L Oral Exposure To The Free Amino Acid Glycine Inhibits The Acute Allergic Response In A Model Of Cow' Scientific Studies 13
L Article: How Goat's Milk Is Healthier Than Cow's Milk Dairy 16
D Coconut Milk Safe Alternative To Cow Milk? Doubts About Milk 10
R Is Cow Foot's Fat Composition The Same As The Rest Of The Other Parts' Ask For Help or Advice 3
P Taurine In Milk And Yoghurt Marketed In Italy . Goat,cow And Buffalo Articles & Scientific Studies 5
HealthisWealth The Best Ruminant Milk - Goat? Carabao? Cow? Sheep? Milk 4
milk_lover Comparison between camel milk and cow milk Milk 11
F What if an animal (cow?)is feed GMO corn and soybeans? Diet, Recipes 2
D goats dairy vs. cow dairy Milk 7
haidut Vitamin B1 and/or biotin may treat Huntington Disease (HD) Scientific Studies 35
haidut Two more cases of prion disease as a result of COVID-19 vaccines Vaccines 90
David PS Reversing Chronic Kidney Disease with Niacin and Sodium Bicarbonate B3/Niacinamide 14
Nuri55 Respiratory muscle weakness due to Cushings Disease Ask For Help or Advice 13
Brave Heart More Evidence That Vitamin D Protects Against Severe COVID-19 Disease and Death D 9
Zpol Did Pentagon turn ticks into bioweapons that spread Lyme Disease? House just approved a study. Society 3
haidut PUFA required for periodontal disease, aspirin may help Scientific Studies 12
Sam321 Isolation, Loneliness, and the Disease Connection Health 0
ddjd CDC has notified all U.S. Hospitals of an imminent Polio-like outbreak of disease among children Ask For Help or Advice 6
yerrag Bacterial Biofilm and its Role in the Pathogenesis of Disease Articles & Scientific Studies 10
haidut Human study - vitamin B1 safe & effective for preventing & treating Alzheimer Disease (AD) Scientific Studies 24
A Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250771/ Mortality From Coronavirus Disease 2019 Increases With Unsaturated Fat and May Be Reduced by Metabolism 1
Lokzo Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson’s disease patients Scientific Studies 1
Mito Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study K 13
Soren Pregnenolone vs Progesterone for Back Pain, Endotoxin, Parkinsons Disease Ask For Help or Advice 6
Hugh Johnson Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease Scientific Studies 11
haidut Endotoxin (LPS) as a cause of liver disease, obesity and diabetes Scientific Studies 10
D New article frames SIBO as a gender specific disease; anabolic steroids may be useful treatment Articles & Scientific Studies 3
haidut Damaged mitochondria may cause 90%+ of Parkinson Disease (PD) cases Scientific Studies 4
Jam COVID-19 Vaccine Associated Parkinson’s Disease, A Prion Disease Signal in the UK Yellow Card Adverse Event Database Scientific Studies 30
tankasnowgod If Common Cold viruses like SARS-Cov-2 can mutate, why doesn't this happen in viruses that cause other disease? Viruses, Parasites, Fungus, Vaccines 25
Indicator Immunization Graphs - Do Vaccines Really Stop Disease? Viruses, Parasites, Fungus, Vaccines 15
Jam Introducing covid-19 as an evolutionary metabolic infectious disease (EMID). The prime cause and representing alternative treatment for Covid-19 (SARS Scientific Studies 2
haidut COVID-19 is an energy deficiency disease Scientific Studies 4
meatbag Stephanie Seneff Ph.D. MIT: SARS-CoV-2 Vaccines and Neurodegenerative Disease Articles & Scientific Studies 7
M A2 cows milk and British government explanation of BSE disease Ask For Help or Advice 5
ddjd OVERWHELMING EVIDENCE COVID-19 IS AN ONCOGENIC, HYPERINFLAMMATORY MITOCHONDRIAL DISEASE OF IRON METABOLISM CAUSED BY THE SPIKE PROTEIN Ask For Help or Advice 36
Nuri55 Can lisuride help with cushings disease with pituitary gland tumor ? Lisuride 2
T Vitamin D heals scar tissue...possible treatment for the dreaded Peyronies Disease? Ask For Help or Advice 6
md_a COVID-19 Is a Vascular Disease: Coronavirus’ Spike Protein Attacks Vascular System on a Cellular Level Scientific Studies 6

Similar threads

Top