energy

The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited...

Hi guys, I've assembled the following stack, in order to address a few goals: - creatine, shilajit, cordyceps, B complex (with niacinamide), vit E, vit K, vit D: testosterone, DHT, anxiety, energy, muscle growth - berberine: gut health, lowering overall inflammation (I have an autoimmune...

As we all know, PUFAs are a metabolic toxin. One of the mechanisms how a high fat diet promotes obesity and metabolic syndrome is by remodeling cardiolipin. Cardiolipin is a unique mitochondrial phospholipid that contains 4 fatty acids. Its main goal is to stabilize the complexes of the electron...

I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of...

About a year ago, a publication came out that demonstrated therapeutic effects of raising the (mitochondrial) NAD/NADH ratio in glaucoma patients. That study used niacinamide (NAM) and suggested that the "irreversible" changes in eye structure seen in glaucoma patients are in fact nothing more...

As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state "andropause". Its official name is age-related hypogonadism and most of that hypogonadism is of the "secondary" type - i.e. the gonads appears to be in fine shape but for...

Almost 25 years ago, Dr. Peat himself wrote a 2-article series in which he outlined arguments in favor of the hypothesis that aging and Alzheimer Disease (AD) are just examples of a more and less systemic sign respectively of declining energy production, and that curing one would lead to a cure...

A few weeks ago, I posted about a human study demonstrating reversal of age-related vision decline by staring at a red light for just a few minutes a day. The mechanism of action proposed in that study had to do with improved mitochondrial function and energy production. Now, it seems another...

On a low A diet I have less energy, can't sleep, have oily and worse skin, but my temps are higher between meals. I found I have to eat liver daily. I get great energy from it, sleep perfectly and have much better skin. But I always find it makes my temps drop faster between meals. Is this...

Peat has mentioned the Creutzfeldt-Jacob disease (CJD) / BSE in several of his articles and interviews and has explained how environmental stress, estrogen, PUFA, ionizing radiation, etc can cause metabolic derangements resulting in the same brain damage so characteristic of this pathology. The...

A rather timely study, which demonstrates once again the crucial role energy plays even in "non-metabolic" diseases such as viral infections. At this point, even mainstream medicine admits that every function of the organism requires energy, so it would be plausible to expect an organism with...

Yet another study demonstrating the crucial role cellular metabolism plays in pathological processes. While most of my posts deal with beneficial effects of improving OXPHOS on various chronic diseases, the study below demonstrates that the same may be true in acute pathologies such as traumatic...

Yet another study demonstrating the remarkable parallels between the decline in function (metabolism) and the structural abnormalities that occur not only in specific pathologies such as AD but also in the generalized degradation known as "aging". FDA currently does not recognize aging as a...

Yet another aspect of health that turns out to be directly controlled by quality/speed of metabolism. I made a few posts in the past demonstrating that progesterone and pregnenolone activate a calcium channel (CatSper) specific to progesterone, which greatly increases sperm motility...

As many of my readers know, the link between niacinamide and schizophrenia dates back at least the 1950s and possibly much earlier. The late Abram Hoffer, one of the founders of the orthomolecular approach, was convinced that stress was a huge factor in mental illness and ran several successful...

This is a great study on so many levels. First, it directly demonstrates that chronic stress leads to mitochondrial dysfunction and reduced oxidative phosphorylation. Second, it demonstrates that glucocorticoids (cortisol) are a direct cause of this energy production downregulation. Third, it...

It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that...

The mainstream medical dogma is that after the onset of menopause, female reproductive potential is essentially zero. I posted a thread recently that challenged that dogma and demonstrated that infertility is essentially an energetic dysfunction process and can be reversed with exposure to red...

Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...

A great study that once again links altruistic behavior with metabolism and energetics. I posted in the past about the studies on egalitarian beliefs / attitudes being more energetically expensive than selfish ones, and as such implying that people with the former beliefs are in better metabolic...