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Hopefully someone who has replies soonHas anyone tried this (either by itself or with other typical products and found that) and found that it not only helped slow down or reverse hair loss, but also there were no side-effects associated which may happen with the oral version?
Thank you I am pretty afraid of this stuff alreadyAll topical Finasteride preparations tested (even those made with advanced formulations) have been shown to go systemic in studies. You might as well be taking the oral version. As someone who has been dealing with Post-Finasteride syndrome for the past 4 years, I do not recommend that you touch this drug in any way, shape or form.
Regarding allopregnanolone, since Finasteride is not supposed to inhibit 5-AR1, it should not do that, at least not directly. The problem has mainly been observed in people who have persisting side effects after quitting, where there is likely a negative-feedback event that occurs after the sharp return of DHT which essentially drastically downregulates the 5-AR1 in the CNS. This is then the cause of persistent brain-fog and a host of other neurological issues. I have them, and believe me, you do not want them.
Damn I badly wanted this to work, Im becoming more skeptical tho, thanks for the inputWAY-316606 is a rather narrow-acting drug which acts on one of the factors that can inhibit the WNT pathway. The safety testing data is lacking so it's questionable what the long-term consequences are. I've spoken to some people who've used it and even though it 'seems' to be reasonably safe I haven't seen that many success stories using it alone.
I don’t think 5ar inhibition is the answer to hair loss for all men, because I think hair loss can be cortisol/adrenal driven and DHT in this scenario would go up to reduce the effect of stress hormones (High shbg typically). Which is very different from metabolic syndrome patients whose DHT is high alongside estrogen because of insulin resistance (low shbg typically).
I’m not surprised @ilhanxx reports insomnia. DHT most likely blocked cortisol/adrenaline driven sleep issues. Now stress is unobstructed and you can’t relax.
IMO if you want to regrow hair you have to address the root cause of hair loss which is far more complex... your best bet would be the anti stress approach + always try to increase glucose oxidation + scalp blood flow.
Anecdotally I had BETTER hair on TRT without finasteride compared to off everything. I have Serum cortisol borderline high and Salivary cortisol over the range. I wonder if male baldness in high cortisol patients is due to insufficient androgen output. Cue half of finasteride patients being non responders (hair loss stabilized at best) and a decent % experiencing low androgen side effects.
And yet if you look at studies, 5ar inhibition stop hairloss for like 90 percent of men.
And yet if you look at studies, 5ar inhibition stop hairloss for like 90 percent of men.
Do you really believe this drug S-Equol would help with hairgrowth? Would you use it yourself if the price werent an issue and you had hairloss?And the side effect rate is only 2% and permanent side effects are unheard of.
I don't think that those studies give a very accurate perspective of what happens in reality. If you look at hair loss forums you will see evidence of that - a good amount of people fail on Finasteride and have to move to something stronger like Dutasteride or flat out androgen receptor blockers like Spiro and Bicalutamide, those are the more insane cases.
In any case it is not the 5AR inhibition that helps but the reduction of DHT. This is the list of all the collateral damage you are causing in your body by inhibiting that enzyme:
View attachment 18872
So that is what you are putting on the chopping block - sacrificing 10 hormones just to get rid of 1 that is actually implicated in hair loss. Madness.
IF I was going to use anything anti-androgenic for hair loss at this point it would probably only be S-Equol since it can be used topically reasonably well and is supposed to bind to ONLY DHT, while not touching 5 alpha reductase at all. It is also an estrogen beta agonist in itself and hence would stimulate regrowth. The only problem is the price.
Thanks for the chart. However, how do we know its even DHT then. Travis wrote that it might be 5a-dihydrocotisol. Also, people including my self did not see any increase in hair worsening with DHT or 11 keto DHT. Haidut mentioned he did not get any reports of hair worsening on DHT. I think fin and Dut work by blocking another hormone other that DHT, and according to the chart we have 10 choices of the possible culprit.And the side effect rate is only 2% and permanent side effects are unheard of.
I don't think that those studies give a very accurate perspective of what happens in reality. If you look at hair loss forums you will see evidence of that - a good amount of people fail on Finasteride and have to move to something stronger like Dutasteride or flat out androgen receptor blockers like Spiro and Bicalutamide, those are the more insane cases.
In any case it is not the 5AR inhibition that helps but the reduction of DHT. This is the list of all the collateral damage you are causing in your body by inhibiting that enzyme:
View attachment 18872
So that is what you are putting on the chopping block - sacrificing 10 hormones just to get rid of 1 that is actually implicated in hair loss. Madness.
IF I was going to use anything anti-androgenic for hair loss at this point it would probably only be S-Equol since it can be used topically reasonably well and is supposed to bind to ONLY DHT, while not touching 5 alpha reductase at all. It is also an estrogen beta agonist in itself and hence would stimulate regrowth. The only problem is the price.
Do you really believe this drug S-Equol would help with hairgrowth? Would you use it yourself if the price werent an issue and you had hairloss?
Alright thank you, also then whats your take of tooical ketoconazole doeant that also reduce DHT? Wouldnt a leave on cream be highly effective?I do believe because I tested the racemic version (R,S)-equol and it gave great results but it also caused me gyno. I do have hair loss, that's why I wrote above that I used Finasteride and developed PFS after quitting it.
I think S-Equol would be safer but you'd need 10-20 mg daily topically and the price is prohibitive, also there are very few suppliers outside of shady Chinamen who will sell you god knows what.
Thanks for the chart. However, how do we know its even DHT then. Travis wrote that it might be 5a-dihydrocotisol. Also, people including my self did not see any increase in hair worsening with DHT or 11 keto DHT. Haidut mentioned he did not get any reports of hair worsening on DHT. I think fin and Dut work by blocking another hormone other that DHT, and according to the chart we have 10 choices of the possible culprit.