Role Of TGF-b1 In Hair Loss

[Arrade]

I think this thread also highlights that healthy livers are a goal to tackle if you want to restore hair

 

[PhilParma]

- methyl palmitate (DeFibron)
- taurine
- green tea extract
- gingko Biloba
- curcumin
- apigenin
- naringenin
- apple cide vinegar
- sage
- aspirin

Does white vinegar oppose TGF-b1, or only apple cider vinegar? I've used them both internally and topically, and white vinegar is preferable because it has less odor...

 

[Tristan Loscha]

animal study on salt consumption and liberation of this cytokine:

Dietary salt modulates renal production of transforming growth factor-β in rats
Wei-Zhong Ying, Paul W Sanders
American Journal of Physiology-Renal Physiology 274 (4), F635-F641, 1998
Transforming growth factors (TGF) are potent multifunctional polypeptides that are involved in renal function and glomerular sclerosis. We postulated that dietary salt modified renal production of TGF-β. An increase in dietary salt produced sustained increases in steady-state levels of mRNA for TGF-β1, -β2, and -β3 in the rat kidney. While serum concentration of TGF-β1 did not change, the 8.0% NaCl diet increased urinary excretion of TGF-β1, indicating enhanced renal production was the source of TGF-β1. Increasing urinary flow rates with diuretics did not further increase synthesis of TGF-β1 in animals receiving the 8.0% NaCl diet. The 8.0% NaCl diet increased production of TGF-β1 in both glomeruli and tubules, although active TGF-β1 was secreted in greater amounts only from glomeruli. Enhanced glomerular production of both inactive and active TGF-β1 induced by the 8.0% NaCl diet was inhibited by tetraethylammonium (TEA) and not glybenclamide. Cardiac production of TGF-β1 also increased on the 8.0% NaCl diet but was not affected by TEA. The results demonstrated that increased dietary salt augmented glomerular TGF-β production by a mechanism that included a TEA-sensitive potassium channel. Dietary salt, by facilitating glomerular expression of TGF-β, may directly promote development of glomerulosclerosis.

 

[Tristan Loscha]

Furthermore:
OBJECTIVE—Transforming growth factor-β (TGF-β) is a prosclerotic growth factor implicated in the pathogenesis of diabetic nephropathy. In addition to high glucose, other factors implicated in renal fibrosis and increased TGF-β synthesis include angiotensin II and high dietary sodium intake. The aim of this study was to examine the effect of angiotensin receptor blockade (ARB) and dietary sodium restriction on the plasma concentration and urinary excretion of TGF-β in hypertensive patients with type 2 diabetes and elevated albumin excretion rate (AER).

 

[Deleted member 5487]

Gut->Fibrosis
Gut->Endotoxin/Cortisol->T~Estrogen->DHT antagonizing estrogen
Cortisol->Tryptophan enzymes->Serotonin-Prolactin-Calcification



formula is something like that.
histamine is a big player and is a product of bacteria


Essentially something sets the cascade off. The only real place that can be is the gut. Either bacterial/leaky. There has to be a cause, the gut seems to start the cascade. Taking 5ar reductase blockers will mess with allopregenolone and stop dht protectitive action. Killing libido and mental health. Much better to attack high up the chain at Cortisol, while gut is fixed.

 

[Tristan Loscha]

maybe lower total NaCl intake to something more physiologic,like 1-3g daily.
it is mediated by DHT by increasing ROS.one way to lower ROS is by consuming proper salt
and thus inhibiting superoxide production by curtailing the substrate chlorine.-

 

[Kray]

Danny Roddy published this very interesting article a few years ago about TGF-b1 and IGF-1 in relation to hair loss. There doesn't seem to be much discussion about it on the forum so i wanted to create a thread.

The Mysterious Conductor of the Hair Cycle Clock

Here's an excerpt:

"
TGF-b1 stimulates the formation of collagen, and overtime this overproduction leads to “perifollicular fibrosis” further reducing the hair follicles’ access to oxygen, sugar, and other nutrients. Levels of TGF-b1 are closely related to the progression of pattern baldness,[23] and alongside hypoxia, the accumulation and activation of mast cells,[24] and an increased concentration of prostaglandins reinforce the view that the defining feature of pattern baldness, a decreased anagen to telogen ratio, is the result of chronic scalp inflammation and an inability to repair.[25] The development of fibrosis in baldness might explain why accidentally setting fire to one's scalp can result in a new head of hair.[26, 27]

TGF-b1 appears to share an inverse relationship with the liver's production of IGF-1,[28,29] and in one experiment supplementary IGF-1 stimulated hair follicle development leading the researchers to say that it might be “a promising drug candidate for baldness therapy.”[30] In the 1990s, Keaely et al. demonstrated that IGF-1 inhibits the catagen and telogen phases of the hair growth cycle favoring anagen.[31, 32] More recently, it was discovered that balding hair follicles secreted “significantly less” IGF-1 and “that the downregulation of IGF-1 may be one of the important mechanisms contributing to male pattern baldness.”[33]

Progesterone is generally supportive of hair growth and has been shown to increases IGF-1[34] and lower aldosterone.[35] The historical treatments for pattern baldness cyproterone acetate and spironolactone are both progesterone-like,[36,37] and spironolactone has been shown to reduce TGF-b1.[38] The harzadous drug, finasteride has been shown to lower TGF-b1,[39] and in a small study, its efficancy was related to the upregulation of IGF-1.[40]

Working in the opposite direction of "the most powerful antifibromatogenic steroid" progesterone,[41] estrogen appears to lower IGF-1 and increases aldosterone and TGF-b1.[42,43,44]"


Having researched substances which antagonise TGF-b1, here are some options:

- methyl palmitate (DeFibron)
- taurine
- green tea extract
- gingko Biloba
- curcumin
- apigenin
- naringenin
- apple cide vinegar
- sage
- aspirin

After re-reading this thread, I wanted to post a Peat article that I found helpful.

Regeneration and degeneration - Types of inflammation change with aging

 

[dreamcatcher]

Danny Roddy published this very interesting article a few years ago about TGF-b1 and IGF-1 in relation to hair loss. There doesn't seem to be much discussion about it on the forum so i wanted to create a thread.

The Mysterious Conductor of the Hair Cycle Clock

Here's an excerpt:

"
TGF-b1 stimulates the formation of collagen, and overtime this overproduction leads to “perifollicular fibrosis” further reducing the hair follicles’ access to oxygen, sugar, and other nutrients. Levels of TGF-b1 are closely related to the progression of pattern baldness,[23] and alongside hypoxia, the accumulation and activation of mast cells,[24] and an increased concentration of prostaglandins reinforce the view that the defining feature of pattern baldness, a decreased anagen to telogen ratio, is the result of chronic scalp inflammation and an inability to repair.[25] The development of fibrosis in baldness might explain why accidentally setting fire to one's scalp can result in a new head of hair.[26, 27]

TGF-b1 appears to share an inverse relationship with the liver's production of IGF-1,[28,29] and in one experiment supplementary IGF-1 stimulated hair follicle development leading the researchers to say that it might be “a promising drug candidate for baldness therapy.”[30] In the 1990s, Keaely et al. demonstrated that IGF-1 inhibits the catagen and telogen phases of the hair growth cycle favoring anagen.[31, 32] More recently, it was discovered that balding hair follicles secreted “significantly less” IGF-1 and “that the downregulation of IGF-1 may be one of the important mechanisms contributing to male pattern baldness.”[33]

Progesterone is generally supportive of hair growth and has been shown to increases IGF-1[34] and lower aldosterone.[35] The historical treatments for pattern baldness cyproterone acetate and spironolactone are both progesterone-like,[36,37] and spironolactone has been shown to reduce TGF-b1.[38] The harzadous drug, finasteride has been shown to lower TGF-b1,[39] and in a small study, its efficancy was related to the upregulation of IGF-1.[40]

Working in the opposite direction of "the most powerful antifibromatogenic steroid" progesterone,[41] estrogen appears to lower IGF-1 and increases aldosterone and TGF-b1.[42,43,44]"


Having researched substances which antagonise TGF-b1, here are some options:

- methyl palmitate (DeFibron)
- taurine
- green tea extract
- gingko Biloba
- curcumin
- apigenin
- naringenin
- apple cide vinegar
- sage
- aspirin

We could apply milk on our heads to grow hair:)

 

[Inaut]

Researchers Study Apigenin For Hair Growth and How It Works

A research study takes a close look at apigenin for hair growth and how it might work to improve hair loss conditions.

ugro.com

 

[johnwester130]

Danny Roddy published this very interesting article a few years ago about TGF-b1 and IGF-1 in relation to hair loss. There doesn't seem to be much discussion about it on the forum so i wanted to create a thread.

The Mysterious Conductor of the Hair Cycle Clock

Here's an excerpt:

"
TGF-b1 stimulates the formation of collagen, and overtime this overproduction leads to “perifollicular fibrosis” further reducing the hair follicles’ access to oxygen, sugar, and other nutrients. Levels of TGF-b1 are closely related to the progression of pattern baldness,[23] and alongside hypoxia, the accumulation and activation of mast cells,[24] and an increased concentration of prostaglandins reinforce the view that the defining feature of pattern baldness, a decreased anagen to telogen ratio, is the result of chronic scalp inflammation and an inability to repair.[25] The development of fibrosis in baldness might explain why accidentally setting fire to one's scalp can result in a new head of hair.[26, 27]

TGF-b1 appears to share an inverse relationship with the liver's production of IGF-1,[28,29] and in one experiment supplementary IGF-1 stimulated hair follicle development leading the researchers to say that it might be “a promising drug candidate for baldness therapy.”[30] In the 1990s, Keaely et al. demonstrated that IGF-1 inhibits the catagen and telogen phases of the hair growth cycle favoring anagen.[31, 32] More recently, it was discovered that balding hair follicles secreted “significantly less” IGF-1 and “that the downregulation of IGF-1 may be one of the important mechanisms contributing to male pattern baldness.”[33]

Progesterone is generally supportive of hair growth and has been shown to increases IGF-1[34] and lower aldosterone.[35] The historical treatments for pattern baldness cyproterone acetate and spironolactone are both progesterone-like,[36,37] and spironolactone has been shown to reduce TGF-b1.[38] The harzadous drug, finasteride has been shown to lower TGF-b1,[39] and in a small study, its efficancy was related to the upregulation of IGF-1.[40]

Working in the opposite direction of "the most powerful antifibromatogenic steroid" progesterone,[41] estrogen appears to lower IGF-1 and increases aldosterone and TGF-b1.[42,43,44]"


Having researched substances which antagonise TGF-b1, here are some options:

- methyl palmitate (DeFibron)
- taurine
- green tea extract
- gingko Biloba
- curcumin
- apigenin
- naringenin
- apple cide vinegar
- sage
- aspirin

ever tried

Pirfenidone, or the gel of it

 

[ddjd]

View: https://twitter.com/SolomonPhoenix_/status/1553092132050571264?t=qWlT0AxSdrpOxllGKa5dHA&s=19