ddjd
Member
- Joined
- Jul 13, 2014
- Messages
- 6,725
Danny Roddy published this very interesting article a few years ago about TGF-b1 and IGF-1 in relation to hair loss. There doesn't seem to be much discussion about it on the forum so i wanted to create a thread.
The Mysterious Conductor of the Hair Cycle Clock
Here's an excerpt:
"
TGF-b1 stimulates the formation of collagen, and overtime this overproduction leads to “perifollicular fibrosis” further reducing the hair follicles’ access to oxygen, sugar, and other nutrients. Levels of TGF-b1 are closely related to the progression of pattern baldness,[23] and alongside hypoxia, the accumulation and activation of mast cells,[24] and an increased concentration of prostaglandins reinforce the view that the defining feature of pattern baldness, a decreased anagen to telogen ratio, is the result of chronic scalp inflammation and an inability to repair.[25] The development of fibrosis in baldness might explain why accidentally setting fire to one's scalp can result in a new head of hair.[26, 27]
TGF-b1 appears to share an inverse relationship with the liver's production of IGF-1,[28,29] and in one experiment supplementary IGF-1 stimulated hair follicle development leading the researchers to say that it might be “a promising drug candidate for baldness therapy.”[30] In the 1990s, Keaely et al. demonstrated that IGF-1 inhibits the catagen and telogen phases of the hair growth cycle favoring anagen.[31, 32] More recently, it was discovered that balding hair follicles secreted “significantly less” IGF-1 and “that the downregulation of IGF-1 may be one of the important mechanisms contributing to male pattern baldness.”[33]
Progesterone is generally supportive of hair growth and has been shown to increases IGF-1[34] and lower aldosterone.[35] The historical treatments for pattern baldness cyproterone acetate and spironolactone are both progesterone-like,[36,37] and spironolactone has been shown to reduce TGF-b1.[38] The harzadous drug, finasteride has been shown to lower TGF-b1,[39] and in a small study, its efficancy was related to the upregulation of IGF-1.[40]
Working in the opposite direction of "the most powerful antifibromatogenic steroid" progesterone,[41] estrogen appears to lower IGF-1 and increases aldosterone and TGF-b1.[42,43,44]"
Having researched substances which antagonise TGF-b1, here are some options:
- methyl palmitate (DeFibron)
- taurine
- green tea extract
- gingko Biloba
- curcumin
- apigenin
- naringenin
- apple cide vinegar
- sage
- aspirin
The Mysterious Conductor of the Hair Cycle Clock
Here's an excerpt:
"
TGF-b1 stimulates the formation of collagen, and overtime this overproduction leads to “perifollicular fibrosis” further reducing the hair follicles’ access to oxygen, sugar, and other nutrients. Levels of TGF-b1 are closely related to the progression of pattern baldness,[23] and alongside hypoxia, the accumulation and activation of mast cells,[24] and an increased concentration of prostaglandins reinforce the view that the defining feature of pattern baldness, a decreased anagen to telogen ratio, is the result of chronic scalp inflammation and an inability to repair.[25] The development of fibrosis in baldness might explain why accidentally setting fire to one's scalp can result in a new head of hair.[26, 27]
TGF-b1 appears to share an inverse relationship with the liver's production of IGF-1,[28,29] and in one experiment supplementary IGF-1 stimulated hair follicle development leading the researchers to say that it might be “a promising drug candidate for baldness therapy.”[30] In the 1990s, Keaely et al. demonstrated that IGF-1 inhibits the catagen and telogen phases of the hair growth cycle favoring anagen.[31, 32] More recently, it was discovered that balding hair follicles secreted “significantly less” IGF-1 and “that the downregulation of IGF-1 may be one of the important mechanisms contributing to male pattern baldness.”[33]
Progesterone is generally supportive of hair growth and has been shown to increases IGF-1[34] and lower aldosterone.[35] The historical treatments for pattern baldness cyproterone acetate and spironolactone are both progesterone-like,[36,37] and spironolactone has been shown to reduce TGF-b1.[38] The harzadous drug, finasteride has been shown to lower TGF-b1,[39] and in a small study, its efficancy was related to the upregulation of IGF-1.[40]
Working in the opposite direction of "the most powerful antifibromatogenic steroid" progesterone,[41] estrogen appears to lower IGF-1 and increases aldosterone and TGF-b1.[42,43,44]"
Having researched substances which antagonise TGF-b1, here are some options:
- methyl palmitate (DeFibron)
- taurine
- green tea extract
- gingko Biloba
- curcumin
- apigenin
- naringenin
- apple cide vinegar
- sage
- aspirin
