Consistency
Member
- Joined
- Jun 17, 2018
- Messages
- 20
Except the squabbling chickens don't control anything. They wouldn't be handing out government funding if they actually were controlling your life.Just anti-fear and anti-control.
Only maybe once a week along with a multi B.
Correlation does not imply causation - Wikipedia
en.m.wikipedia.org
Exactly. Niacinamide is the most powerful antiviral.
An aberrant STAT pathway is central to COVID-19
These viral components induce signal transducer and activator of transcription 1 (STAT1) dysfunction and compensatory hyperactivation of STAT3. In SARS-CoV-2-infected cells, a positive feedback loop established between STAT3 and plasminogen activator inhibitor-1 (PAI-1) may lead to an escalating cycle of activation in common with the interdependent signaling networks affected in COVID-19. Specifically, PAI-1 upregulation leads to coagulopathy characterized by intravascular thrombi. An aberrant STAT pathway is central to COVID-19
Recent studies have shown that STAT3 plays important roles in viral infection and pathogenesis. STAT3 exhibits a proviral function in several viral infections. https://www.futuremedicine.com/doi/10.2217/fvl-2018-0033
We further revealed that decreased NAD inactivated sirtuin 1, resulting in increased signal transducer and activator of transcription 3 (STAT3) acetylation and phosphorylation, and STAT3 activation. Repletion of nicotinamide (Niacinamide) or
**Nicotinic acid does inactivate STAT3 and therefore inhibit viral replication however high levels of nicotinic acid can lead to excessive bleeding. Nicotinamide(niacinamide) doesn’t have these side effects however Nicotinamide does lower blood sugar by stimulating the release of insulin in everyone including type 1 diabetics. Lowering blood sugar is another positive function in regards to reducing viral replication.
A warning on NAC: NAC(N-Acetyl cysteine) is a commonly used supplement which inhibits STAT3(proviral) inhibitors like Nicotinamide and therefore will inhibit the antiviral effects of Nicotinamide(Niacinamide) if taken at the same time or afterwards. (Redirecting) This has been my experience when I had covid myocarditis. Nicotinamide would cause tachycardia with preserved ejection fraction as an indication of immediate viral clearance and NAC would stop the tachycardia. Eventually the increased viral load symptoms returned after this experiment. It took me a while to understand why Nicotinamide 500mg was causing tachycardia with preserved ejection fraction and unknowingly lowering my viral load. I eventually felt virus free after many hours of experiencing tachycardia.
More evidence on the antiviral effects of Nicotinamide.
One of the notable genes in humans identified is BST2, which the study calls "a potent inhibitor of SARS-CoV-2 replication." And expression of this gene was found to reduce replication of the virus by 53 per cent and reduce the viral release by 74 per cent when compared to control cells. U.S. study identifies the genes that fight coronavirus infections
Functional landscape of SARS-CoV-2 cellular restriction
A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant o…
www.sciencedirect.com
We further examined for commonly enriched motives in the enhancer regions of upregulated genes of the NAM(Nicotinamide) metabolism pathway (NNMT, NAMPT, MAT2A, AHCY, BST1, and BST2). JCI Insight - Nicotinamide metabolism regulates glioblastoma stem cell maintenance
Vitamin B3 'helps kill superbugs' - Vitamin B3 'helps kill superbugs'
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