ddjd
Member
- Joined
- Jul 13, 2014
- Messages
- 6,731
im noticing some really nice effects of a few raw sage leaves (Salvia officinalis) before bed. really helping with falling asleep and sleep quality it seems. i would say overall effect is highly anti-estrogenicAllopregnanolone acts like a positive allosteric modulator of GABA-A receptor and is high at luteal phase via increased progestrone. Apparently even adding more of Prog has little effects. Seems like GABA system is desensitized by the chronic administration of the synthetic gaba medication.
Salvia Officinalis extract has flavonoids that act the same way, positively modulating GABA-A, and could be helpful as alternative, maybe even restore sensitivity.
Estrogen modulates serotonin, blocking estrogen could bring out serotonin inhibiting effects. Have you tried anti-serotonin ?