aguilaroja
Member
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- Jul 24, 2013
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FredSonoma said:I have no idea if my idea about serotonin is right... but I wonder if blocking serotonin blocks an important function of serotonin, which is helping to empty out the bowels. I definitely felt more "backed up" and "clogged up" when I was taking cypro. I love how low serotonin feels... but I think I have high serotonin because something else is fked up in my body, and the serotonin is to try to fix that or something.
fredsonoma's thoughts and experiences about serotonin raised several important points. I'll aim to keep things brief, or let others move the discussion to a different thread. answersfound made a post for specific problem solving.
First, in "serotonin syndrome" very elevated serotonin states, diarrhea is often found. So it is plausible that lowering serotonin could slow gut motility.
Second, while it is clear that large amounts of serotonin are present in the gut, a lot of the specific roles are far from clarified by responsible scientists.
Third, a useful physiologic action, say, gut motility, can be stimulated by sustainable paths (abundant metabolic energy) or less sustainable ones (emergency metabolic energy response to inflammation/irritation)
http://www.ncbi.nlm.nih.gov/pubmed/19361459
Role of serotonin in gastrointestinal motility and irritable bowel syndrome.
Sikander A1, Rana SV, Prasad KK.
Clin Chim Acta. 2009 May;403(1-2):47-55. doi: 10.1016/j.cca.2009.01.028. Epub 2009 Feb 4.
"Serotonin (5-HT) is an important signaling molecule in the gut targeting enterocytes, smooth muscles and enteric neurons."
"Tegaserod, 5-HT(4) partial agonist is used in constipation predominant IBS while alosetron, a 5-HT(3) antagonist used in IBS with diarrhea."
http://www.ncbi.nlm.nih.gov/pubmed/23797870
Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets.
Mawe GM1, Hoffman JM.
Nat Rev Gastroenterol Hepatol. 2013 Aug;10(8):473-86. doi: 10.1038/nrgastro.2013.105. Epub 2013 Jun 25.
"Conventional functions of 5-HT involving intrinsic reflexes include stimulation of propulsive and segmentation motility patterns, epithelial secretion and vasodilation. Activation of extrinsic vagal and spinal afferent fibres results in slowed gastric emptying, pancreatic secretion, satiation, pain and discomfort, as well as nausea and vomiting. Within the gut, 5-HT also exerts nonconventional actions such as promoting inflammation and serving as a trophic factor to promote the development and maintenance of neurons and interstitial cells of Cajal."
"5-HT3 receptor antagonists and 5-HT4 receptor agonists have been used to treat functional disorders with diarrhoea or constipation, respectively,..."