Fortnight On Pregnenelone : Experiences, Benefits, Negatives

[jaywills]

Peaters,

Thought I would write an overview of my experiences with Pregnenelone to see if it can help anyone and to gain further insight into what I am experiencing on Pregnenelone.

I havebeen taking 200mg per day for a fortnight in the evening prior to bed.

Brand:MRM
Daily Dose:200mg

Context:
I am a 25 year old male, diagnosed hypothyroid but not taking ant thyroid medication. Previously hypogonadal but increased testosterone naturally without any supps to mid-range levels.

Following the latest episodes on KMUD thought id supplement with Pregnenelone to see if it could balance and optimise my hormones further.

Ill start with the Positives:
- Memory recall has been significantly sharper, bith short and long term, and I am able to remember experiences from years ago
- increased general sense of wellbeing and joyfullness. Seem funnier and more easy going. Anxiety dissapeared
- Penis size seems enlarged and erection quality and frequency improved
- Increase in muscle mass (albeit I am weightlifting and eating in a surplus)
- increase hair growth. Particularly on my upper legs which had no hair prior to supplementation.
- ability to sweat again and sweat a lot
- easier to fall asleep and sleeping deeper. Nightmares seem more positive replacing nightmares.

Now the negatives :
- immense and i mean immense water retention. I know this is water as its squigdy and wobbly and has come on in the two weeks. Additionally to remove thia excess water i attended a sauna and dropped about 10kg. Woke up consoderably lighter and more defined.
- sexual apetite has incr3ased to the point in where im watxhing porn again and feel a need to orgasm. Less sexual control...
- gynecomastia is flaribg and water retention in belly and chest.

I emailed Dr Peat about the water retention and he replied with:

"Working on thyroid first is important. I think some of the pregnenolone currently being sold is contaminated with something estrogenic."

The estrogenic piece is interesting. My estrogen has undoubtedly increased but are the other beneficial hormones increasing in line?

Ive read other posts on this forum and read similar experiences.

So i dont know where to go from here. My thoughts:
- is the water retentiom a good thing or fuelling repair? Ive xome from a background of undereating amd low thyroid
- should i stop supplemeting or drop the dose
- do i need to work on my thyroid or start supplementing thyroid hormone

Any feedback and suggestions would be greatly appreciated or if anybidy has experienced something similar would be great to hear your understanding or what you did?

Jay.

 

[Wagner83]

Optimal Dose Of Pregnenolone For Androgen Synthesis

If you browse the forums you'll see quite a few people reporting anti androgenic/estrogenic effect from pregnenolone (and dhea).

 

[milk_lover]

Yeah the water retention may have come from too much conversion to progesterone and thus anti-androgenity. If you read the link that Wanger has provided, you will see studies suggesting no more than 10mg is taken to ensure the anti-androgenity effect of pregnenolone. It would be interesting to check if there is any estrogenity in commercial pregnenlone brands like MRM. I have the same brand too. Maybe it would be a good idea to ask for a certificate from them.

 

[jaywills]

Thank you very much @Wagner83 . And @milk_lover Will read through when I get a spare moment but this sounds spot on.

 

[Rand56]

That is interesting about what Ray said about current brands being estrogenic. Awhile back I did a short stint of 200 mg's per day of Preg, also the MRM brand. I had water retention from it too.

 

[Arnold Grape]

That seems like an incredibly high starting dose to take and maintain on the regular, especially for a younger person - The advice given on Pregnenolone seems to vary wildly, but my observation is consistent with 200 mg daily being high and that it might be contributing to your new symptoms. My own experience with (Life Extension) Pregnenolone at 50 mg daily is that it ends up being too much and converting to stress hormones at some point, down the line. I do notice some of the other things you mentioned, however, including increased androgens and an uplifted mood. The delicate balance is that too much leaves me feeling angry.

 

[Tarmander]

I looked into Preg a couple years ago and found that it all comes from China, and who knows what goes on there. Maybe there are domestic manufacturers of the raw ingredient now days?

 

[DaveFoster]

I have a very similar experience. I've been taking 600-800 mg per day, and it helps with depression and motivation. It seems to improve heat tolerance, but drinking too much coffee with a large amount of pregnenolone, and one needs to just sit down and sweat for a while. Using coffee + pregnenolone, I've noticed hair regrowth as well, but it's modest.

 

[superhuman]

What about the powder from healthnatura then? i guess that is suppose to be really good and clean source?

 

[johnwester130]

""Working on thyroid first is important. I think some of the pregnenolone currently being sold is contaminated with something estrogenic.""

Yes, healthnatura sell the best pregnenolone. I have bought countless brands - I think their pregnenolone is the best, and best price per serving.

Beware of cheap pregnenolone. Cheap pregnenolone is often pregnenolone acetate and companies are not required to disclose that. Our pregnenolone is bio identical, micronized, and 99.3% pure.

 

[superhuman]

great @johnwester130

 

[Frankdee20]

I don't understand how people aren't getting palpitations or accelerated heart rate, or crushing headaches, with that high of Pregnenalone

 

[Memento]

I have a very similar experience. I've been taking 600-800 mg per day, and it helps with depression and motivation. It seems to improve heat tolerance, but drinking too much coffee with a large amount of pregnenolone, and one needs to just sit down and sweat for a while. Using coffee + pregnenolone, I've noticed hair regrowth as well, but it's modest.

Hi Dave! Are you still taking such high amounts? Are you noticing any side effects from long term use?

 

[Arnold Grape]

Don't take that much - there is nobody suggesting that amount of Preg, including Peat at the upper threshold

 

[Memento]

Just curious, Dave seems to be a special case in many ways according to his posts.

 

[Arnold Grape]

Just curious, Dave seems to be a special case in many ways according to his posts.

Actually - this just seems to be a character affectation of people in and around this sub: while there is great information to be had, it's difficult to distinguish between experimentation and extreme behavior patterns and/ or people doing dumb things.

 

[Braveheart]

Actually - this just seems to be a character affectation of people in and around this sub: while there is great information to be had, it's difficult to distinguish between experimentation and extreme behavior patterns and/ or people doing dumb things.

Mon, that's for sure...beware

 

[DaveFoster]

Hi Dave! Are you still taking such high amounts? Are you noticing any side effects from long term use?

It depends on the day, and I haven't experienced any side effects whatsoever, but I seldom take pregnenolone in isolation.

 

[johnsmith]

I started adding a few drops of Prenenelone(Stressnon) on top of my 4 daily drops of Pansterone(Dhea+Preg). I think I really like the extra Pregnenelone.

Is Pregnenelone something you can stay on for the rest of your life? I have read it is good to give a week break every couple months or so, to get rid of diminished effects. I get depressed when I stop using this stuff. I've had the idea of maybe using something else, like 5a-dhp or Androsterone, during the week off, to try and counter the depression during this break, but I don't know if this will prevent the undoing of desensitivity to Preg or whatever it is that the break is giving me?

I've been on Pansterone for at least 2 years now. I had very bad effects when I first took Pregnenelone which was in a 100mg pill form. I had so much energy I thought I was going to explode (maybe it was estrogen). I switched to Pansterone and I was fine.

 

[Arnold Grape]

@johnsmith what did you find out? I feel like I had a similar experience to you, save for I'm still experimenting with the Pansterone. (I feel like Dhea might give me palpitations.) The depression does seem to go w/ Preg.

There is a definite difference between taking Preg orally and/ or rubbing it on the skin. (I've been told you should under no circumstances attempt to snort Preg power - I wish I was making up that I actually inquired.) Recently I've been taking the Health Natura powder and mixing it with oil to apply to the skin. I've also been told this is an inefficient delivery mechanism, but I beg to differ. Have not tried the Idea stuff in dmso