mostlylurking
Member
Ray Peat's articles about acetylcholine are from the perspective of having TOO MUCH acetylcholine. Derrick Lonsdale's articles about acetylcholine are from the perspective of having TOO LITTLE acetylcholine. I think in today's world, it is more common to have a deficiency in acetylcholine (caused by thiamine deficiency) which points to Lonsdale's articles being more helpful. But this does not make Ray Peat wrong about acetylcholine. I think both of these men's writings have been immensely helpful to me.The importance of acetylcholine in vagus nerve health (eyes, sinuses, digestion, anti IBS-c, for mood, sleep, muscle force, etc) and maybe to lower brain serotonin i think. Mainstream science is also wrong on acetylcholine, cause high acetylcholine needs more GABA and enaught dopamine to counter the reduction in serotonin. Serotonin both calm down or mask a GABA deficiency and also mask any dopamine deficiency, that's who acetylcholine alone can cause either headache/migraine or depression respectively and it's not a cure all either until you fix dopamine and GABA and norepinephrine tolerance. Peat has said acetylcholine will "burn out" your vagus nerve, because of it's relationship with histamine but i don't understand how a nerve can burn out only because it's being stimulated, from my understanding it needs to have other factors to get damage like vitamin deficiency or something because of how many regulatory mechanism there are for normal function, bit I'm not an expert in nerves (neither Dr Peat was as a young researcher). Dr Peat approach was initially based on androgens and sex hormones research.
Thiamine is needed to make acetylcholine; if you have a thiamine deficiency you're in big trouble. Thiamine deficiency is implicated in many/most/all(?) brain diseases (i.e. Alzheimer's, Parkinson's, senile dementia, etc.) Thiamine is required to clear serotonin from the brain.
You may find Derrick Lonsdale's articles of interest:
Derrick Lonsdale, MD
www.hormonesmatter.com