I don't know much about this apparently genetic form of neonatal diabetes I, but looking at the mutation in question I do not see how it related to thiamine at all, yet thiamine is therapeutic. So, the question that naturally arises is - can thiamine potentially help all cases of diabetes I?
Recovered Insulin Production after Thiamine Administration in Permanent Neonatal Diabetes Mellitus with A Novel SLC19A2 Mutation. - PubMed - NCBI
"...RESULTS: The patient with PNDM had c.848G>A (p.W283X) homozygous mutation in SLC19A2. His father had a wild type SLC19A2 (c.848 G) and his mother was c.848 G/A heterozygous. The patient and his father both had diploid genotype (c.848 A/A and c.848 G/G). After oral thiamine administration, the patient demonstrated gradual increasing fasting c-peptide and remarkable decreasing insulin requirement. The database searching revealed that thiamine treatment was effective and improved diabetes in 63% of the patients with SLC19A2 deficiency."
"...CONCLUSIONS: We identified a novel SLC19A2 mutation (c.848G>A; p.W283X) most likely inherited as segmental uniparental isodisomy in our patient. Insulin insufficiency in PNDM caused by SLC19A2 deficiency can be corrected by thiamine supplementation. The differential diagnosis of SLC19A2 deficiency should be included in children with PNDM to allow for early treatment."
Recovered Insulin Production after Thiamine Administration in Permanent Neonatal Diabetes Mellitus with A Novel SLC19A2 Mutation. - PubMed - NCBI
"...RESULTS: The patient with PNDM had c.848G>A (p.W283X) homozygous mutation in SLC19A2. His father had a wild type SLC19A2 (c.848 G) and his mother was c.848 G/A heterozygous. The patient and his father both had diploid genotype (c.848 A/A and c.848 G/G). After oral thiamine administration, the patient demonstrated gradual increasing fasting c-peptide and remarkable decreasing insulin requirement. The database searching revealed that thiamine treatment was effective and improved diabetes in 63% of the patients with SLC19A2 deficiency."
"...CONCLUSIONS: We identified a novel SLC19A2 mutation (c.848G>A; p.W283X) most likely inherited as segmental uniparental isodisomy in our patient. Insulin insufficiency in PNDM caused by SLC19A2 deficiency can be corrected by thiamine supplementation. The differential diagnosis of SLC19A2 deficiency should be included in children with PNDM to allow for early treatment."