A Subset Of Diabetes I Can Be Cured By Vitamin B1 (thiamine)

haidut

Member
Joined
Mar 18, 2013
Messages
17,608
Location
USA / Europe
I don't know much about this apparently genetic form of neonatal diabetes I, but looking at the mutation in question I do not see how it related to thiamine at all, yet thiamine is therapeutic. So, the question that naturally arises is - can thiamine potentially help all cases of diabetes I?

Recovered Insulin Production after Thiamine Administration in Permanent Neonatal Diabetes Mellitus with A Novel SLC19A2 Mutation. - PubMed - NCBI

"...RESULTS: The patient with PNDM had c.848G>A (p.W283X) homozygous mutation in SLC19A2. His father had a wild type SLC19A2 (c.848 G) and his mother was c.848 G/A heterozygous. The patient and his father both had diploid genotype (c.848 A/A and c.848 G/G). After oral thiamine administration, the patient demonstrated gradual increasing fasting c-peptide and remarkable decreasing insulin requirement. The database searching revealed that thiamine treatment was effective and improved diabetes in 63% of the patients with SLC19A2 deficiency."

"...CONCLUSIONS: We identified a novel SLC19A2 mutation (c.848G>A; p.W283X) most likely inherited as segmental uniparental isodisomy in our patient. Insulin insufficiency in PNDM caused by SLC19A2 deficiency can be corrected by thiamine supplementation. The differential diagnosis of SLC19A2 deficiency should be included in children with PNDM to allow for early treatment."
 

aguilaroja

Member
Joined
Jul 24, 2013
Messages
835
...this apparently genetic form of neonatal diabetes I,
...thiamine is therapeutic. So, the question that naturally arises is - can thiamine potentially help all cases of diabetes I?

Recovered Insulin Production after Thiamine Administration in Permanent Neonatal Diabetes Mellitus with A Novel SLC19A2 Mutation. - PubMed - NCBI

"...Insulin insufficiency in PNDM caused by SLC19A2 deficiency can be corrected by thiamine supplementation. The differential diagnosis of SLC19A2 deficiency should be included in children with PNDM to allow for early treatment."
Thanks for the reference.

For almost as long as there has been genetics, geneticists have had to expert-‘splain things about “penetrance” and “expressivity” to account for different gene effects.

The party line about the SLC19A2 gene, which codes for Thiamine transporter 1, is that, in autosomal recessive cases, there are problems with (megaloblastic) anemia, diabetes(mellitus), and sensorineural deafness. The number of descriptions of heterozygous SLC19A2 gene case reports is even smaller.

Hopefully, eventually, more details of thiamine transport will be worked out, more observation of heterozygous SLC19A2 people will be done, and the view of thiamine transport difficulties as “monogenic” will be scrutinized.

It may be of interest that the Human Thiamine Transporter, THTR-2 (SLC19A3) also transports both Metformin (an oral diabetes drug) and famotidine.

SLC19A2 - Wikipedia

Adaptive regulation of human intestinal thiamine uptake by extracellular substrate level: a role for THTR-2 transcriptional regulation
“…optimization of thiamine level seems to have the potential in preventing diabetic retinopathy and blocking tissue damage caused by hyperglycemia of diabetes”

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)
 

AretnaP

Member
Joined
Mar 27, 2017
Messages
180
Haidut do you think real solutions to health problems can come out of a capitalist society? Real solutions just aren't as profitable as garbage it seems.

For example: not only do they sell you SSRIs which do not work they sell you some other drug to "help the antidepressant work better". Seems like as long as profit is the thing that matters most nothing can ever get done.
 
Joined
Nov 21, 2015
Messages
8,510
Haidut do you think real solutions to health problems can come out of a capitalist society? Real solutions just aren't as profitable as garbage it seems.

For example: not only do they sell you SSRIs which do not work they sell you some other drug to "help the antidepressant work better". Seems like as long as profit is the thing that matters most nothing can ever get done.

I find it very sad that there is so much anticapitalist sentiment in the world today and on this board.

The profit motive is the only motive that works to create vast and rapid improvement in our world.

We don't have real capitalism anyway, what we have is really more fascism. The great drug companies and the government work together to promote big medicine and big agriculture.

But that doesn't mean that capitalism doesn't work.

We should give it a try before we say it doesn't work., LOL.
 

Tarmander

Member
Joined
Apr 30, 2015
Messages
3,519
I find it very sad that there is so much anticapitalist sentiment in the world today and on this board.

The profit motive is the only motive that works to create vast and rapid improvement in our world.

We don't have real capitalism anyway, what we have is really more fascism. The great drug companies and the government work together to promote big medicine and big agriculture.

But that doesn't mean that capitalism doesn't work.

We should give it a try before we say it doesn't work., LOL.

I hear ya. I think that is because people don't get capitalism. I kind of wish that instead of being call capitalism, it was called individualism. The whole point is to hold the individual's right to private property in the highest regard. It is extremely ethical. But somehow people think it's basically a monarchy that focuses on making money at all costs or something. I have even seen people call nazi Germany capitalist! Hilarious.
 
Last edited:
Joined
Nov 21, 2015
Messages
8,510
I hear ya. I think that is because people don't get capitalism. I kind of wish that instead of being call capitalism, it was called individualism. The whole point is to hold the individual's right to private property in the highest regard. It is extremely ethical. But somehow people think it's basically a monarchy that focuses on making money at all costs or something. I have even seen people call nazi Germany capitalist! Hilarious.

I think Ray is anti-capitalist, which is one of the only points where I think he is sadly very wrong.
 

AretnaP

Member
Joined
Mar 27, 2017
Messages
180
I find it very sad that there is so much anticapitalist sentiment in the world today and on this board.

The profit motive is the only motive that works to create vast and rapid improvement in our world.

We don't have real capitalism anyway, what we have is really more fascism. The great drug companies and the government work together to promote big medicine and big agriculture.

But that doesn't mean that capitalism doesn't work.

We should give it a try before we say it doesn't work., LOL.
Saying that it "doesn't work" or "does work" oversimplifies it.

There are benefits to having a capitalist system and drawbacks as well.
My country (the USA) is definitely capitalist, we have privately owned means of production.
One of the benefits is that there is always and incentive to work and make products that people want.
One of the drawback is that big corporations will try to manipulate the government, which is why we will most likely always have "crony capitalism" rather than "real capitalism".

I think Ray is anti-capitalist, which is one of the only points where I think he is sadly very wrong.
I'm surprised that this is your biggest complaint about Peat, my biggest problem is the whole anti-vegetable thing due to them having phytoestrogens.
 

Tarmander

Member
Joined
Apr 30, 2015
Messages
3,519
I think Ray is anti-capitalist, which is one of the only points where I think he is sadly very wrong.

I think he has talked about some of the positives of communism and its similarity to certain childhood attributes. I haven't ever heard him come out against individual rights like private property, more about the cultural control of science. Maybe he has, I'd be interested to see a quote.

Saying that it "doesn't work" or "does work" oversimplifies it.

There are benefits to having a capitalist system and drawbacks as well.
My country (the USA) is definitely capitalist, we have privately owned means of production.
One of the benefits is that there is always and incentive to work and make products that people want.
One of the drawback is that big corporations will try to manipulate the government, which is why we will most likely always have "crony capitalism" rather than "real capitalism".


I'm surprised that this is your biggest complaint about Peat, my biggest problem is the whole anti-vegetable thing due to them having phytoestrogens.

Peat isn't anti all veggies. He likes carrots, mushrooms, and bamboo shoots. He even talks about boiling greens for minerals.

Saying there are benefits and drawbacks to capitalism makes it sound like it's just another choice among govts to choose from, but it's actually a huge advance in human rights. It's like saying there are benefits and drawbacks to slavery, which there are, but that's not really getting the point.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,608
Location
USA / Europe
Thanks for the reference.

For almost as long as there has been genetics, geneticists have had to expert-‘splain things about “penetrance” and “expressivity” to account for different gene effects.

The party line about the SLC19A2 gene, which codes for Thiamine transporter 1, is that, in autosomal recessive cases, there are problems with (megaloblastic) anemia, diabetes(mellitus), and sensorineural deafness. The number of descriptions of heterozygous SLC19A2 gene case reports is even smaller.

Hopefully, eventually, more details of thiamine transport will be worked out, more observation of heterozygous SLC19A2 people will be done, and the view of thiamine transport difficulties as “monogenic” will be scrutinized.

It may be of interest that the Human Thiamine Transporter, THTR-2 (SLC19A3) also transports both Metformin (an oral diabetes drug) and famotidine.

SLC19A2 - Wikipedia

Adaptive regulation of human intestinal thiamine uptake by extracellular substrate level: a role for THTR-2 transcriptional regulation
“…optimization of thiamine level seems to have the potential in preventing diabetic retinopathy and blocking tissue damage caused by hyperglycemia of diabetes”

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

Very interesting! So, famotidine may be able to treat these cases as well right? Possibly in higher doses, but still.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,608
Location
USA / Europe
Haidut do you think real solutions to health problems can come out of a capitalist society? Real solutions just aren't as profitable as garbage it seems.

For example: not only do they sell you SSRIs which do not work they sell you some other drug to "help the antidepressant work better". Seems like as long as profit is the thing that matters most nothing can ever get done.

I think if the system was truly capitalist it would have produced some solutions by now. But what we have is not capitalism, it is fascism plain and simple. Smaller companies that may try to bring a solution to the market can (and do) get easily crushed by large corporations through litigation if they threaten the status quo. The purpose of the corporation is to NOT compete, the exact opposite of what capitalism should be all about. A large corporation has a mind of its own and will do what it can to generate profits while doing as little useful work as possible. The government is not any better, the "deep state" has controlled governments for the last 60 years or so and as a result there can be no just government as even good laws get circumvented by special interests quite easily and often in direct violations of the law. The worst is the merging of the large corporations with the deep-state to create truly diabolical entities that operate beyond the reach of law or any sense of humanity really.
Capitalism/communism have very little to do with the world we live in today.
 
Last edited:

Regina

Member
Joined
Aug 17, 2016
Messages
3,384
Location
Chicago
I think if the system was truly capitalist it would have produced some solutions by now. But what we have is not capitalism, it is fascism plain and simple. Smaller companies that may try to bring a solution to the market can (and do) get easily crushed by large corporations through litigation if they threaten the status quo. The purpose of the corporation is to NOT compete, the exact opposite of what capitalism should be all about. A large corporation has a mind of its own and will do what it can do generate profits while doing as little useful work as possible. The government is not any better, the "deep state" has controlled governments for the last 60 years or so and as a result there can be no just government as even good laws get circumvented by special interests quite easily and often in direct violations of the law.
Capitalism/communism have very little to do with the world we live in today.
:emoji_dart:
 

Leonie Cent

New Member
Joined
Apr 12, 2017
Messages
3
Haidut do you think real solutions to health problems can come out of a capitalist society? Real solutions just aren't as profitable as garbage it seems.

For example: not only do they sell you SSRIs which do not work they sell you some other drug to "help the antidepressant work better". Seems like as long as profit is the thing that matters most nothing can ever get done.
After a lot of research on the internet, I've come across many natural treatments for diseases such as cancer. Simple treatments which can be easily employed. So, I ask myself the same question, and as well: When will commonsense get a fair go?
 
Similar threads
Thread starter Title Forum Replies Date
Rinse & rePeat Brewer's Yeast A Cure For Diabetes And More.. Supplements, Pharmaceutical Drugs 5
haidut Stress (cortisol) as the driver of hyperglycemia in type II diabetes Scientific Studies 0
forterpride Reversing type 2 diabetes Ted Talk Ask For Help or Advice 2
haidut Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes Scientific Studies 41
haidut Dietary PUFA In Childhood Causes Diabetes And Irreversible (male) Infertility Scientific Studies 4
N Anti-Peat Saturated Fat TERRIBLE For Liver Health & Diabetes. Compared To PUFA Debate - Anti-Peat 140
charlie Vitamin B1 Could Reverse Early-stage Kidney Disease In Diabetes Patients Scientific Studies 3
L Dairy-rich Diet Linked To Lower Risks Of Diabetes And High Blood Pressure Dairy 3
haidut High-carb (65%-85%) Diets Therapeutic In Diabetes Scientific Studies 0
Hgreen56 How Do You Think About This? 'How To Take Niacin Without Getting Diabetes' Supplements, Pharmaceutical Drugs 4
zarrin77 Mega Salt Diet Improves Type 1 Diabetes In Children And Increases Glucose Oxidation Scientific Studies 28
haidut Nut (PUFA) Consumption May Cause Diabetes Even Without Obesity Scientific Studies 0
haidut PUFA May Drive Obesity, Insulin Resistance, Liver Issues In Diabetes II Patients Scientific Studies 0
W Reversing Type 2 Diabetes IdeaLabs 10
A.D. Foods For Family Member With Type 2 Diabetes Diet 2
R Gut Microbiota Mediates Intermittent-fasting Alleviation Of Diabetes-induced Cognitive Impairment Scientific Studies 0
Mauritio Serotonin Causes Obesity, Diabetes, Fibrosis,liver Damage ,increases Endotoxin And NO Scientific Studies 0
K Gut Health And Diabetes Blood Sugar 6
haidut The Keto Diet Works Only For A Week, Then It Causes Obesity And Diabetes Scientific Studies 33
haidut America’s Favorite Oil Causes Diabetes, Obesity, Autism, And Liver / Brain Disease Scientific Studies 0
haidut Progesterone May Treat Diabetes, Obesity, And Metabolic Syndrome Scientific Studies 6
haidut Vitamin D Strikingly Therapeutic For Type II Diabetes Scientific Studies 15
haidut Burning More Fat And Less Glucose Leads To Diabetes Scientific Studies 19
Mito Dairy Foods, Dairy Fat, Diabetes, And Death: What Can Be Learned From 3 Large New Investigations? Articles & Scientific Studies 8
L Can Mirtazapine Cause Diabetes / High Blood Glucose? Pharmaceutical Drugs 9
EssntlFttyBstrd Chelating Selenium And Chromium? Se & Cr Cause Diabetes And Suppress Copper Metabolism Ask For Help or Advice 4
methylenewhite Sustained Release DNP Made At Yale Treats NAFLD, Diabetes II And Other Metabolic Abnormalities Scientific Studies 0
Lokzo Cyproheptadine = Diabetes/Insulin Resistance. Myth? Cyproheptadine 1
Amazoniac When The Primary Brain Is Plagued: Diabetes As Predominantly An Intestinal Disease Cancer, Degenerative Diseases 1
Watubi Has Anyone Reversed Their Type II Diabetes Following RP Advice? Blood Sugar 85
Lokzo Donkey Milk (Equus Asinus) As A Potential Treatment Strategy For Type 2 Diabetes Scientific Studies 16
haidut Even A Tiny Amount Of Talc May Cause Diabetes II, Benadryl May Reverse It Scientific Studies 25
haidut Mitochondrial Damage And Fatty Acid Buildup, Not Glucose, May Drive Diabetes Scientific Studies 11
Oraganic4me What Drives Inflammation In Type 2 Diabetes? Not Glucose, Says New Research Blood Sugar 9
Kingpinguin Could Someone Explain How Inflammation Causes Diabetes (metabolic Disease) On Cell Level Metabolism 7
Chaos Artificial Sweeteners Cause Diabetes In Mice - Through Gut Microbiome Changes Scientific Studies 1
Lokzo L-serine: A Neglected Amino Acid With A Potential Therapeutic Role In Diabetes Scientific Studies 1
Kelj Reversion To Normoglycaemia Occurs More Often Than Progression To Diabetes Blood Sugar 18
haidut Statins More Than Double The Risk Of Diabetes Compared To Non-users Scientific Studies 0
Beefcake My Sister Cured Hashimotos, Type 2 Diabetes And PCOS Diagnose Within A Month Diet 42
A Has Anyone Out There Healed Their Type 2 Diabetes Using The Peatarian Diet? Blood Sugar 43
DaveFoster Dairy Fat May Protect Against Type II Diabetes Scientific Studies 6
haidut PUFA (metabolites) Drive Heart Failure And Possibly Diabetes Scientific Studies 4
AlphaCog Higher Bone Mineral Density In Older Men With Diabetes And Impaired Fasting Glucose Scientific Studies 0
haidut Blocking Endotoxin (LPS) May Reverse/cure Diabetes Type I Scientific Studies 5
L New Evidence Of Synergism Between Vitamins A And D — Can They Cure Diabetes? Fat-Soluble Vitamins 2
Mauritio Fructose As Diabetes Treatment? As Effective As Anti-diabetic Drugs Health 5
jzeno Dr. McDougall: Cure Type 2 Diabetes With Sugar & White Rice Miscellaneous Health Discussions 49
R 1 Year Low Carb Intervention Cured 60% Of Patients From Diabetes Scientific Studies 66
S How To Transition And Avoid Diabetes Or Can A Diabetic The Ray Peat Way? Diet 17

Similar threads

Top