1. TruffleGnocchi

    Video explaining potential testosterone increasing mechanism of Tadalafil, with visuals

    Tadalafil: Erectile Dysfunction Cure? Testosterone Booster? Non-Responders? [Study 147-154 Analysis] I know nitric oxide is bad in Ray Peat's view and there are already posts about estrogen reduction. But still interesting video explaining the actual mechanisms of Tadalafil, Nitric Oxide...
  2. haidut

    How vitamin K protects from diabetes

    The study discovered a new protein requiring vitamin K as a co-factor. It has long been known that vitamin K regulates both the synthesis and carboxylation of osteocalcin, with the latter subsequently regulating functions as diverse as blood clotting, bone mineralization, soft-tissue...
  3. haidut

    Blocking estrogen (and/or taking DHEA) prevents menopausal obesity, diabetes, osteoporosis, etc

    A remarkable study, which for a reasonable person should unilaterally invalidate the mainstream dogma that menopause is a condition of estrogen "deficiency", and that most of the symptoms associated with menopause (of which osteoporosis, infertility, obesity and insulin resistance are among the...
  4. Mauritio

    Thyroid hormone increases anti-oxidant enzymes, glucocorticoids lower them

    In this study they looked at the influence of certain hormones (thyroid hormone, insulin and glucocorticoids) on certain anti-oxidant enzymes (SOD, catalase, glutathione peroxidase). They showed that thyroid increased catalase and superoxide dismutase, while glucocorticoids lower them...
  5. haidut

    Glycine may prevent/treat diabetic neuropathy

    A very interesting study, which adds more evidence in favor of the recent hypothesis that glycine (just as taurine) is in fact an essential amino acid. Namely, despite our ability to synthesize glycine, as needed, from the truly essential amino acids, its absence in the diet leads to pathologies...
  6. Sapien

    Ideal potassium/carb ratio?

    With a lack of quality fruit juice available, refined sugar makes up a good bulk of my diet. Since it doesn’t have any potassium, I eat some (well cooked) potatoes every day for potassium. Anyone know a good K/ carb ratio to shoot for ? (for insulin managing purposes). Also, do I have to worry...
  7. haidut

    Another "paradox" - glucocorticoids cause inflammation, insulin blocks it

    As many of my readers know, I am not a fan of the ubiquitous usage of both bioidentical and synthetic glucocorticoids (GC) in medicine. Once used only in the most severe cases, some form of GC therapy awaits virtually all patients in a hospital (regardless of condition), and doctors are now...
  8. haidut

    Niacinamide increases ATP/NAD, lower glucose/cortisol in humans

    A great new study demonstrating for the first time in a human experiment what hundreds of animal studies had suggested in the past. Namely, that niacinamide can serve as a reliable precursor to NAD+ and by raising the NAD/NADH ratio results in improved glucose metabolism and higher ATP levels...
  9. haidut

    SHBG may be a good test for liver (metabolic) health

    A very good study, which probably runs counter to the "mantra" most bodybuilders adhere to - i.e. they would say one must keep their SHBG low in order to increase levels of "free" steroids since, the claim goes, only free steroids are active and capable of influencing cells. If SHBG is high, the...
  10. haidut

    The "burning mouth" syndrome may be due to vitamin deficiencies, hypothyroidism

    Just a quick post since I get a lot of emails about this issue, and apparently the rates have increased a lot since the pandemic began. According to the study below, this symptoms can be caused by insulin resistance, vitamin D/B6/B1 or zinc deficiencies, or hypothyroidism (high TSH). Looking at...
  11. A

    What happens right after eating a meal?

    which neurotransmitters or hormones are being changed in the span of 15 minutes after eating a meal? Asking because I always get fatigued after eating, and the cause is not reactive hypoglycemia if you were going to mention it.
  12. haidut

    Inhibiting lipolysis may treat diabetes

    Probably nothing surprising to my readers, but I think the study below is still important as it is one of the very few that openly state that diabetes is driven not by genetics but by excessive free fatty acids in the blood. While it does not mention it directly, the study is a great...
  13. haidut

    DHT can stop aging of the pancreatic beta-cells (insulin-producing)

    Another great study, which demonstrates that far from being a "villain" (in both males and females) DHT is in fact a crucial and positive factor in health. In this specific study below, it was demonstrated that DHT dose-dependently inhibited the aging/dysfunction of the pancreatic beta-cells...
  14. haidut

    DHEA causes fat-loss and improved glucose metabolism in humans

    Another study corroborating the role of DHEA as one of the "youth" hormones. A recent study already demonstrated that DHEA can reverse aging of the human immune system, which usually goes hand in hand with lower cortisol and improved metabolism. The proven anti-cortisol effects of DHEA are...
  15. haidut

    Replacing starch with sucrose increases metabolism, prevent obesity

    A study that will certainly generate controversy in the low-carb blogosphere, but the findings are hard to dispute. Namely, feeding a diet for 15 weeks, in which 74.3% of the calories come from carbs in the form of starch was clearly obesogenic, caused insulin resistance and elevated blood...
  16. haidut

    DHT better (and safer) than testosterone for improving blood pressure, insulin levels

    A great human study on the beneficial effects of androgens for a variety of metabolic biomarkers associated with insulin resistance and diabetes II. The only gripe I have with this study is that they claim it was conducted with "healthy" men when in reality all men had low plasma total...
  17. CreakyJoints

    Deer antler extract and possible applications for degenerative bone and joint disorders.

    I recently came across these (the oldest of which is from 2019) and found them quite interesting. I wonder if anyone has any thoughts, experiences, or any more literature on the subject? Bioactive Molecular Discovery Using Deer Antlers as a Model of Mammalian Regeneration Deer antler extract...
  18. pauljacob

    Insulin Given After Colonoscopy

    Two days ago my brother went for a colonoscopy (he's 65), and after the procedure they gave him insulin because his blood sugar went up to 400. Yesterday they wanted to give him another shot of insulin but he refused and they told him they can't release him unless he takes the shot. Are two...
  19. LLight

    The significance of glucose, insulin and potassium for immunology and oncology: a new model of immunity
  20. RealNeat

    Cell Free Mitochondria?

    Researchers Find Cell-Free Mitochondria Floating in Human Blood what do we suppose is the reasoning behind this? Does it in some way expand upon, microvesicles, exosomes, cell to cell communication? Or is it just remnants of the "life cycle" of a blood cell.