1. haidut

    Replacing starch with sucrose increases metabolism, prevent obesity

    A study that will certainly generate controversy in the low-carb blogosphere, but the findings are hard to dispute. Namely, feeding a diet for 15 weeks, in which 74.3% of the calories come from carbs in the form of starch was clearly obesogenic, caused insulin resistance and elevated blood...
  2. haidut

    DHT better (and safer) than testosterone for improving blood pressure, insulin levels

    A great human study on the beneficial effects of androgens for a variety of metabolic biomarkers associated with insulin resistance and diabetes II. The only gripe I have with this study is that they claim it was conducted with "healthy" men when in reality all men had low plasma total...
  3. CreakyJoints

    Deer antler extract and possible applications for degenerative bone and joint disorders.

    I recently came across these (the oldest of which is from 2019) and found them quite interesting. I wonder if anyone has any thoughts, experiences, or any more literature on the subject? Bioactive Molecular Discovery Using Deer Antlers as a Model of Mammalian Regeneration Deer antler extract...
  4. pauljacob

    Insulin Given After Colonoscopy

    Two days ago my brother went for a colonoscopy (he's 65), and after the procedure they gave him insulin because his blood sugar went up to 400. Yesterday they wanted to give him another shot of insulin but he refused and they told him they can't release him unless he takes the shot. Are two...
  5. LLight

    The significance of glucose, insulin and potassium for immunology and oncology: a new model of immunity
  6. RealNeat

    Cell Free Mitochondria?

    Researchers Find Cell-Free Mitochondria Floating in Human Blood what do we suppose is the reasoning behind this? Does it in some way expand upon, microvesicles, exosomes, cell to cell communication? Or is it just remnants of the "life cycle" of a blood cell.
  7. Tarmander

    Gut Protocol For Insulin Resistance, Metabolism, And Energy

    I wanted to share this amazing gut protocol that I have been on for the last few months (results below) I am in a unique position as a type 1 diabetic in that my pancreas produces little to no insulin on its own. This gives me an insight into what supplements and herbs do to insulin needs in...
  8. haidut

    Blocking Endotoxin (LPS) May Reverse/cure Diabetes Type I

    Yet another study demonstrating the key role of endotoxin in the pathology of perhaps the most widespread chronic disease - diabetes. The study below discovered that the proliferation of the insulin-producing beta-cells in the pancreas is controlled almost entirely by the TLR4/TLR2 receptor...
  9. P

    “NO” To Autophagy: Fat Does The Trick For Diabetes

    “NO” to Autophagy: Fat Does the Trick for Diabetes During the progression from obesity to diabetes, a critical attribute is inability to maintain metabolic homeostasis under excessive energy and nutrient exposure, which triggers insulin resistance. Intensive research efforts have linked chronic...
  10. nigma

    Potassium Or Insulin As The 'insulin' Effect

    There is a somewhat well known idea of Ray's that says insulin plays a smaller part in the insulin effect than insulin itself. While potassium looks to be the main actor in getting glucose into cells. from 'Glycemia, starch, and sugar in context' "Insulin is important in the regulation of blood...
  11. P

    The Effect Of Training Volume And Intensity On Improvements In Muscular Strength And Size In Resista

    on every parameter high intensity( heavier weight lower reps with longer rest between sets) is superior to high volume exercise , body fat , lean mass, power. also hormones ; cortisol ,T , igf .... everything is better! The effect of training volume and intensity on improvements in muscular...
  12. yerrag

    Protocol For Curing Type 2 Diabetes, Anyone?

    Has anyone here ever attempted to cure type 2 diabetes successfully? A friend just started diabetes medication, and in a party we were in, he passed out because the medication made his blood sugar go way low. I told him I'll see if I can provide a method where he can get his condition cured...
  13. haidut

    Anti-adrenaline Drugs Like Clonidine May Prevent Diabetes Type I

    Peat mentioned a few times that the pancreatic damage seen in type I diabetes is caused by prolonged exposure to PUFA, as unsaturated fats are toxic to the insulin-producing beta cells in that organ. Many of the cases of new onset diabetes I occur after a period of extreme exhaustion and/or...
  14. P

    Low Dose Doxycycline Decreases Systemic Inflammation And Improves Glycemic Control, Lipid Profiles,

    Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in <i>db/db</i> mice Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in...
  15. haidut

    Delirium (and Dementia/AD) Is Caused By Inability To Oxidize Glucose

    Ray has written about the metabolic origins of Alzheimer disease (AD) and I posted quite a few studies on the links between AD and PUFA metabolites as well as insulin resistance in the brain. I even mentioned on one of Danny Roddy's shows that there is a proposal by NIH to reclassify AD as...
  16. haidut

    A Subset Of Diabetes I Can Be Cured By Vitamin B1 (thiamine)

    I don't know much about this apparently genetic form of neonatal diabetes I, but looking at the mutation in question I do not see how it related to thiamine at all, yet thiamine is therapeutic. So, the question that naturally arises is - can thiamine potentially help all cases of diabetes I...
  17. Mito

    A Review Of The Carbohydrate–insulin Model Of Obesity

    European Journal of Clinical Nutrition - A review of the carbohydrate-insulin model of obesity The carbohydrate–insulin model of obesity theorizes that diets high in carbohydrate are particularly fattening due to their propensity to elevate insulin secretion. Insulin directs the partitioning of...
  18. Steven Bussinger

    Insulin Neuroprotection And The Mechanisms

    Insulin Neuroprotection and the Mechanisms Insulin, Neuroprotection, GABA, Glucose, Glycogen, Ischemia, Glutamate Introduction Insulin is the only endocrinology hormone to decrease blood glucose. In addition, insulin serves as a growth factor, modulating mitogenesis, growth, and...
  19. P

    Manganese Mimics Insulin

    -manganese increases co2 production from glucose -inhibits lipolysis -increases lipogenesis Regulation of glucose utilization and lipogenesis in adipose tissue of diabetic and fat fed animals: effects of insulin and manganese. - PubMed - NCBI
  20. haidut

    Androsterone - A Potential Treatment For Insulin Resistance And Diabetes

    In another recent thread, I posted about androsterone's potent thyromimetic effects. Given the ability of thyroid hormone to improve insulin sensitivity and even reverse diabetes type II, it would not be surprising that androsterone would also exhibit such effects. And indeed, androsterone...