Mar 18, 2013
USA / Europe
Even though this is officially considered an epidemiological study, it was a lot more controlled than that. The patients were given vitamin supplementation and compliance was enforced as much as possible. So, you can call this an open label trial. And given that the population studied was one with much higher than average incidence of those cancers, the vitamins should be even more protective in the general population. It is also worth noting that this trial also found increased cancer risk from folic acid supplementation, in agreement with a number of recent studies done in the USA.

B Vitamins Linked to Gastrointestinal Cancer Risk - Medical News Bulletin

"...The supplement groups were administered various doses of vitamins and minerals in combination. Roughly half the participants were administered a combination including 3.2mg of riboflavin (Vitamin B2) and 40mg of niacin (Vitamin B3), called Factor B by the NIT researchers. Blood was drawn from each subject before they were administered a supplement or placebo, and was kept frozen for later analysis. In 1996, levels of Vitamins B2, B6, B9, and B12, and flavin mononucleotide (FMN) – a product of B2 metabolism – were measured for each blood sample."

"...Vitamin B2 was associated with a lower risk of OSCC. This association was stronger in women than in men, and in those >60 compared to other age groups. Overall, the prevalence of OSCC among those with the highest levels was 44% lower than that of the 25th percentile: for those assigned to a Factor B-containing group the prevalence was 40% lower, and for those who were not, the prevalence was 49% lower. B2 was also associated with a decreased risk of GCA in those 50 or older. Participants in the 50th and 75th percentiles for B6 levels were 40% and 47% more likely to have OSCC than those in the 25th percentile, respectively. Vitamin B9 was associated with an increased risk of GCA, though this association was not found to be significant when Factor B status was taken into account. Those with higher B9 levels in Factor B groups had a slightly higher prevalence of OSCC overall. Vitamin B12 was associated with a slightly decreased risk of OSCC. FMN was associated with an increased risk of OSCC in participants assigned to a Factor B group."


Aug 15, 2015
Energin has no B12. Does this study convince you to add B12 to the formula? Or further studies are needed? Great stuff as usual. Thanks. I enjoyed the series of glycine studies yesterday. Great insight.


Thread starter
Mar 18, 2013
USA / Europe
Energin has no B12. Does this study convince you to add B12 to the formula? Or further studies are needed? Great stuff as usual. Thanks. I enjoyed the series of glycine studies yesterday. Great insight.

There are several new studies linking high serum B12 with several cancers. It is not definitive yet if the link is causative but vitamin B12 as well as folic acid is known to stimulate cancer growth in vitro. I would need to see more evidence before I include B12, but folic acid is likely not going to be included unless new evidence comes out.
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