Vitamin D supplementation may lower suicide risk by 50%

haidut

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Suicide rates have been rising for the last 20+ years and have truly gotten out of control since the pandemic started. As usual, the mainstream version is that this is not an environmentally-driven issue but a "complex" interplay of genetic factors and poor lifestyle choices. As such, medicine has no solution for the suicide crisis except lobotomizing every patient it can gets its hand on with massive doses of SSRI drugs. Despite these record-setting SSRI consumption rates, suicide rate continues to rise. The study below demonstrates that there may be an embarrassingly easy/cheap solution that can halve the suicide rate. Namely, supplementation with vitamin D (either D2 or D3), with daily doses in the 2,00 IU - 5,000 IU range or weekly doses in the 40,000 IU - 50,000 IU range. Higher doses had a stronger effect on reducing suicides than lower doses, but even the "high" doses (in the range of 5,000 IU daily) are in fact physiological and commonly prescribed to people in Northern countries to take continuously, with no ill effects. Since chronic depression is one of the main risk factors for suicide, a possible mechanism of action if the antidepressant effect of vitamin D demonstrated by prior animal/human studies.

The association between vitamin D serum levels, supplementation, and suicide attempts and intentional self-harm - PubMed
"...Vitamin D3 and D2 supplementation were associated with a 45% and 48% lower risk of suicide attempt and self-harm ((D2 Hazard Ratio (HR) = 0.512, [95% CI, 0.457, 0.574]; D3 HR = 0.552, [95% CI, 0.511, 0.597])). Supplemented black veterans and veterans with 0-19 ng/ml vitamin D serum levels were at ~64% lower risk relative to controls (Black Veteran HR: 0.362 [95% CI: 0.298,0.440]; 0-19 ng/ml HR: 0.359 [95% CI: 0.215,0.598]). Supplementation with higher vitamin D dosages was associated with greater risk reductions than lower dosages (Log Average Dosage HR: 0.837 [95% CI: 0.779,0.900])."

Treating low vitamin D levels may help ward off suicide, study suggests - UPI.com
"...A new study hints that treating low vitamin D levels with supplements might have a critical benefit for certain people: a decreased risk of attempting suicide. In a study of more than 1 million U.S. veterans, researchers found that those prescribed vitamin D were nearly 50% less likely to attempt suicide over eight years, versus those who were not prescribed the supplements....When the researchers weighed other factors, like physical and mental health conditions, vitamin D supplementation was still linked to a 45% to 48% lower risk of attempting suicide. And it turned out that the association was strongest among veterans who had low vitamin D to start (blood levels lower than 20 ng/mL), and among Black veterans. The body naturally synthesizes vitamin D when the skin is exposed to sunlight. But darker skin, with more melanin, results in less vitamin D production."
 

Michael Mohn

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I wonder if low vitamin d is a cause or effect of pathology. A lot of people have good vitamin d status but live in the north and their vitamin d intake from food and sunlight might be low. Other people have good sunlight exposure and good vitamin d intake, they even might supplement with vitamin d but their d status is low, this is a common problem in Australia for example. Is vitamin d status a proxy for bad liver health or other pathology?
 

Ben.

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I wonder if low vitamin d is a cause or effect of pathology. A lot of people have good vitamin d status but live in the north and their vitamin d intake from food and sunlight might be low. Other people have good sunlight exposure and good vitamin d intake, they even might supplement with vitamin d but their d status is low, this is a common problem in Australia for example. Is vitamin d status a proxy for bad liver health or other pathology?

I was wondering about that too. So far i came to believe it might be both.

Pathogenic influences are known to negatively influence the function of the Vitamin D receptor. This is especially true of:


  • EBV (epstein barr virus) (1)
  • CMV (cytomegalovirus) (2)
  • Borrelia burgdorferi (Lyme bacteria) (3)
  • Wifi radiation (electrosmog) has shown to adversely affect the VDR (4)
  • Gliotoxin, a virulence factor and mycotoxin of fungi (20). Gliotoxins are produced by numerous fungi. Though the study cited identified gliotoxin release from aspergillus fumigatus, it is known that gliotoxins can also be produced by penicillium and trichoderma


Personally i develop temporary eye sight issues with vitamin d supplementation and have thus far only found one other person who has that aswell and that guy has indeed lyme disease. Apparantly borrelia blocks the conversion of vitamin d in the kidneys? I dont know.

Borrelia and the VDR
In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses.9)


Studies have indicated that the dysregulation of VDR may lead to exaggerated inflammatory responses, raising the possibility that defects in Vitamin D and VDR signaling transduction may be linked to bacterial infection and chronic inflammation. Further characterization of Vitamin D/VDR will help elucidate the pathogenesis of various human diseases and in the design of new approaches for prevention and treatment. Jun Sun 10)


Since the VDR is at the heart of the innate immune system, bacteria can survive by discovering how to disable it through a variety of different actions. Actions accumulate and are more powerful than individual actions. In keeping with evolutionary theory, a growing number of substances and species have been shown to downregulate the activity of the VDR, one of which is Borrelia burgdorferi. Live Borrelia burgdorferi reduced VDR expression in monocytes (phagocytes) by 50 times, and lysates (“dead” Borrelia) reduced it by 8 times 11)


  • 8) Human Tick-Borne Diseases in Australia., Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ, Front Cell Infect Microbiol9p3(2019)
  • 9) Microbial manipulation of receptor crosstalk in innate immunity. Hajishengallis G, Lambris JD, Nat Rev Immunol11p187-200(2011 Mar)
  • 10) Vitamin D and mucosal immune function. Sun J, Curr Opin Gastroenterolp(2010 Jul 15) Download the PDF from VitaminDWiki
  • 11) Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta. Salazar JC, Duhnam-Ems S, La Vake C, Cruz AR, Moore MW, Caimano MJ, Velez-Climent L, Shupe J, Krueger W, Radolf JD, PLoS Pathog5pe1000444 (2009 May)
 

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