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Vitamin A (retinol) Inhibits Aromatase

Discussion in 'Scientific Studies' started by haidut, Feb 17, 2014.

  1. haidut

    haidut Member

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    I mentioned this in my other posts but wanted to post at least one direct study for those interested in the vitamin A anti estrogenic effect:
    Retinol inhibits aromatase activity and expression in vitro. - PubMed - NCBI
    "...Aromatase converts androgens into estrogens and is thought to supply a local source of estrogen that facilitates the growth of hormone-responsive tumor cells. Inhibition of aromatase is therefore an important chemopreventive strategy. We investigated the effect of retinol and selected retinoids on the activity and expression of aromatase in two human carcinoma cell lines in vitro. Retinol (ROH) and all-trans retinoic acid (ATRA) significantly inhibited aromatase activity in a concentration-dependent manner in microsomes isolated from JEG-3 human placental carcinoma cells, whereas 9-cis and 13-cis retinoic acid had significant inhibitory activity only at the highest concentrations tested. Similar results were observed in an assay of cellular aromatase activity in MCF-7 human breast cancer cells. Enzyme kinetic studies by double-reciprocal plot demonstrated that ROH inhibited microsomal aromatase activity in a mixed manner. In addition, ROH suppressed both the basal and cAMP-induced expression of aromatase mRNA in MCF-7 cells and inhibited transcription controlled by a cAMP-responsive element. These results suggest that aromatase activity and expression are a molecular target of ROH and chemopreventive retinoids, an activity that may underlie, in part, their inhibitory effects on hormone-dependent cancer."
     
  2. Bahaa El wazzan

    Bahaa El wazzan Member

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    Civil engineer
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    Hello haidut

    You said in other posts
    That taking fat soluble vitamins with olive oil is better absorbed

    I'm taking some d and some e

    But what about the dosage that should I take of K and A
    ???

    And can I take them those four vitamins together with olive oil altogether ?

    I would appreciate your reply
    Thanks in advance
     
  3. Momado965

    Momado965 Member

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    Do you still wonder?
     
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