aromatase

  1. haidut

    SSRI drugs decrease androgens / progestogens, increase estrogens

    As hard as it is to believe, this is the actual title of the study - i.e. SSRI drugs are bonafide endocrine disruptors. As it turns out, all of the six most-prescribed SSRI drugs the study looked at behaved not only as inhibitors of gonadal androgen synthesis (e.g. testosterone, DHT), but also...
  2. Hans

    Georgi Dinkov on aromatase inhibition, Gonadin+, testosterone optimization and serotonin antagonism

    Part 2 of my podcast with Georgi. You can watch part 1 here. View: https://youtu.be/7WJhifddXYw
  3. haidut

    Stress ups cortisol/estrogen/prolactin, drops DHT, causes male infertility and prostate issues

    If you try to discuss infertility with a fertility/reproductive specialist or an endocrinologist, and mention that chronic stress may be a factor in infertility, you will probably get laughed out of the room. This is not just speculation. This exact same thing happened to several friends and...
  4. S

    Does breast tissue (gynecomastia) increase aromatisation?

    I have a theory that the more breast tissue you have, the more aromatase enzymes you carry, thus the more testosterone gets converted to testosterone. Unfortunately I haven't been able to find anything to back up this thought other than my own experience. If anyone could provide some insight...
  5. A

    K2/Kuinone/ Aromatase and HAIR LOSS

    Used to have extremely thick hair around 1 month ago, I have seen rapid decreasing. Think it might be k2 since I take alot daily. Apparently the fact that it inhibits aromatase is the reason why it effects hair. Is aromatse necessary for hair then. I am going to drop k2. HOW LONG do you think it...
  6. F

    Supplements to prevent gynecomastia?

    Hi guys, I'm male 35 and lately I've been dealing with some low T/thyroid symptoms, such as low body temperature (chilling hands), anxiety, overthinking, worrying and brain fog. Last year I took bloodworks and they showed low vit D and low LH, so I've started vitamin D and magnesium. I'm going...
  7. haidut

    Estrogen May Be The Cause Of "estrogen-negative" Breast Cancer

    IMO, one of the biggest medical frauds so far is the idea that androgens (especially DHT) cause and promote prostate cancer. We now have an abundance of evidence (posted on this blog) that it is instead deficiency of androgens and/or excess of estrogens that initiates and drives the progression...
  8. haidut

    Male Sexual Function Does NOT Require Estrogen

    It is a "sacred" mantra in the medical and sports worlds - i.e. "estrogen is crucial for males, without it they won't have any sex life". This mantra is also part of the justification given for the currently ongoing COVID-19 clinical trials with males receiving estrogen in the hope it will...
  9. meatbag

    Perinatal Administration Of Aromatase Inhibitors In Animal Models Of Human Male Homosexuality

    Perinatal Administration of Aromatase Inhibitors in Rodents as Animal Models of Human Male Homosexuality: Similarities and Differences -- Abstract In this chapter we briefly review the evidence supporting the existence of biological influences on sexual orientation. We focus on basic research...
  10. haidut

    Inhibiting Estrogen Synthesis May Treat / Prevent Ectopic Pregnancy

    I just made a post about the role of estrogen in male infertility, which matches perfectly the evidence about estrogen's role as a metabolic inhibitor, and an agent that causes atrophy in both male and female gonads. Male Fertility Depends On Intensity Of (sperm) Metabolism Now, a new study...
  11. haidut

    Inhibiting Aromatase (to Lower Estrogen) May Treat Gastric (stomach) Cancer

    Yet another study demonstrating the causative link between estrogen and a cancer considered to be hormone-independent. Gastric cancer is one of the leading causes of cancer-deaths worldwide, and especially Asian countries. It is considered very hard to treat and most patients are diagnosed at...
  12. haidut

    Pregnenolone Is As Potent As Progesterone As An (irreversible) Aromatase Inhibitor

    Progesterone does not need an introduction here and most people are likely aware of its antiestrogenic effects. A few years ago, I posted a thread with an old French study showing that a 500mg daily dose pregnenolone completely blocked estrogen's effects - an effect identical to what...
  13. Lokzo

    Calcium Deficiency Increases Aromatase And Subsequent Estrogen In Male Rats

    A calcium-deficient diet caused decreased bone mineral density and secondary elevation of estrogen in aged male rats-effect of menatetrenone and elcatonin. @haidut You will like this :)
  14. haidut

    Reducing Estrogen Synthesis Regenerates Thymus Destroyed By Aging

    Recently, I posted a thread showing that immune dysfunction (thymus shrinkage) which developed with aging (and excess of PUFA, estrogen, cortisol) explains cancer incidence much better than any genetic model. Immune Dysfunction (cortisol/estrogen/PUFA), Not Genetics, Causes Cancer The quote...
  15. haidut

    Raising Serum Androgens Using DHEA, Pregnenolone, And Vitamin K

    User testimony (4/26/2021): My Experiences With Raising Androgens Log (Pansterone, k2, magnoil) Many people use supplements like DHEA, pregnenolone, and progesterone with the goal of raising their androgens and lowering estrogen. While this approach works for raising tissue levels of steroids...
  16. haidut

    Androsterone - A Potent Steroidal Aromatase Inhibitor

    It is well-known in medical circles (at least in doctors over 50) that some androgens like DHT are potent aromatase inhibitors (AI). In fact, before the advent of modern AI drugs like letrozole, anastrozole and fadrozole the 5-AR androgens were a mainstream therapy for estrogen-receptor-positive...
  17. haidut

    Low-dose DHEA Inhibits Aromatase By 35% And Endotoxin Blocks That Effect

    I found this study while researching the conversion of DHEA into steroids with immunomodulating effects. As you can see (attached picture), a DHEA concentration of 1µM inhibited aromatase activity by about 35%. This concentration of DHEA can be easily achieved with 3mg - 5mg topical DHEA in...
  18. P

    Aromatase Inhibition Significanty Enhance Nerve Regeneration

    Sex differences in the effectiveness of treadmill training in enhancing axon regeneration in injured peripheral nerves. - PubMed - NCBI Exercise in the form of daily treadmill training results in significant enhancement of axon regeneration following peripheral nerve injury. Because androgens...
  19. haidut

    Estrogen Causes Epilepsy/seizures; Aromatase Inhibitors Are Viable Treatment

    In perhaps what is one of the most striking and open confirmations of Ray's views, this study finally acknowledges what the man has been saying for years. Estrogen is a major cause (and maybe even THE cause) of epilepsy and its associated seizures, and inhibiting estrogen synthesis may be a...
  20. P

    Aromatase Inhibitors Regenerate The Thymus In Aging Male Rats

    http://www.ncbi.nlm.nih.gov/pubmed/1521922 Abstract The thymus can be regenerated in aging rats by surgical or chemical castration and regeneration is inhibited by testosterone, which may exert this effect, at least in part, through its conversion to estradiol. An attempt has been made to...
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