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That's your opinion. Sorry, I disagree. This person is in tune enough with his bodily reactions that he recognizes that he worsened on a little methylene blue. It's a clue. It points to a serotonin problem. Research into serotonin would be helpful. There might be additional reasons for this negative reaction, but the fact that methylene blue is an MAO inhibitor is important.This person doesn't need to go through a course of abstruse self-examination or biochemical scrutiny in order to ferret out the occult reason for his reaction.
Niacinamide should helpOnly one drop. Feeling super hot and anxiety. Any advices ?
getting panic attacks god damn. Pls advices
Thanks. The fruits: pineapple, banana, plums are ones I've been eating and now I'm thinking this may be related to my IBS attacks. Something to consider. I knew Ray said bananas were highly industrialized and not desirable, but I didn't know about the serotonin aspect.I interpret this differently from what you have described. It is my understanding that an MAO inhibitor (methylene blue is one) blocks the reuptake of serotonin. In other words, it keeps the body from getting rid of the serotonin, thus INCREASING the overall amount of serotonin that is in the brain. It is the increased serotonin that causes extreme anxiety. Maybe I misunderstood what you wrote and we are saying the same thing?
High serotonergic foods also cause problems for me. These include pineapple and bananas. If one of these are eaten before or immediately after consuming some methylene blue, my negative reaction is even worse.
I've learned that thiamine deficiency also causes high anxiety. A diet high in sugars and starch tends to use up the body's thiamine because it is required to process the sugars/starch into ATP. This is another facet that you might consider looking into. Evidently, thiamine also helps to lower serotonin.
andEffect of thiamine deficiency on brain serotonin turnover - PubMed
Serotonin turnover has been investigated in regional brain areas of rats made thiamine deficient by pyrithiamine (PT). Following intracisternal injection of [14C]5-hydroxytryptamine ([14C]5-HT), a marked increase in the accumulation of [14C]5-hydroxyindoleacetic acid ([14C]5-HIAA) was found in...pubmed.ncbi.nlm.nih.gov
Serotonin Syndrome and Thiamine: Is There a Connection? - Hormones Matter
A mild deficiency of thiamine is responsible for the large number of the polysymptomatic illnesses reported.www.hormonesmatter.com
If your thiamine status is low or is blocked, coffee will make it worse because it blocks the function of thiamine.
Ray Peat has an article about serotonin here: Serotonin, depression, and aggression - The problem of brain energy. This article has lost its layout format. If you copy/paste into a Word document it will be much easier to read.
Here's an article about serotonin in fruits: Serotonin in Fruits – Functional Performance Systems (FPS)
quote:
Serotonin content of foods: effect on urinary excretion of 5-hydroxyindoleacetic acid.
Feldman JM, Lee EM.
Using a highly specific radioenzymatic assay we determined the serotonin concentration in 80 types of foods. The following fruits had a high serotonin concentration (mean +/- SEM) expressed in micrograms/g weight: plantain 30.3 +/- 7.5; pineapple 17.0 +/- 5.1; banana 15.0 +/- 2.4; Kiwi fruit 5.8 +/- 0.9; plums 4.7 +/- 0.8; and tomatoes 3.2 +/- 0.6. Only nuts in the walnut or hickory family had a high serotonin concentration expressed in micrograms/g weight; butternuts 398 +/- 90; black walnuts 304 +/- 46; English walnuts 87 +/- 20; shagbark hickory nuts 143 +/- 23; mockernut hickory nuts 67 +/- 13; pecans 29 +/- 4; and sweet pignuts 25 +/- 8. Ingestion of these fruits and nuts resulted in an increase in urinary 5-hydroxyindoleacetic acid excretion with no change in platelet serotonin concentration. The above foods should not be eaten while a urine is being collected for 5-hydroxyindoleacetic acid analysis.
This list matches my personal food sensitivity list. huh....
What aspect of MB are you wanting?I‘d love it if there was a compound like Methylene Blue but without the MAO-Ai properties
I've been on high thiamine since the first of February. I've known that I can't eat bananas for a long time. However, I tried eating an organic one about a week ago and I had zero negative reaction. Since thiamine seems to help regulate serotonin, I wonder if that is the reason. Thiamine also helps heal the gut and it's possible that since my gut is in much better shape now maybe that's why I didn't react badly.Thanks. The fruits: pineapple, banana, plums are ones I've been eating and now I'm thinking this may be related to my IBS attacks. Something to consider. I knew Ray said bananas were highly industrialized and not desirable, but I didn't know about the serotonin aspect.
Update is that we never eat bananas anymore. Don't miss them.Thanks. The fruits: pineapple, banana, plums are ones I've been eating and now I'm thinking this may be related to my IBS attacks. Something to consider. I knew Ray said bananas were highly industrialized and not desirable, but I didn't know about the serotonin aspect.