Sulfur in Black Seed oil.

[June]

Anyone know if there are any sulfur molecules in Black seed oil? I've gotten contradicting information from different companies. I'm searching for some clarity. Thank you!

 

[cs3000]

Not sure, but black seed oil / nigella sativa might not good to take because of the serotonergic + acetylcholine effects

it elevates serotonin & tryptophan levels a lot according to some studies. https://www.researchgate.net/figure...T-levels-Values-are-mean-SD-n6_fig2_260843200 and inhibits acetylcholinesterase a lot (rasies acetylcholine).

high levels of both of these are common in people with depression

https://www.researchgate.net/publication/24250916_Repeated_administration_of_Nigella_sativa_decreases_5-HT_turnover_and_produces_anxiolytic_effects_in_rats

Increased 5-HT Levels Following Repeated Administration of Nigella sativa L. (Black Seed) Oil Produce Antidepressant Effects in Rats

The seeds of Nigella sativa L., commonly known as black seed or black cumin, and its extracts are used in folk medicine in the Middle East and in Asian countries for the promotion of good health and as a remedy for many ailments. These seeds have many ...

www.ncbi.nlm.nih.gov

Neurochemical and behavioral effects of Nigella sativa and Olea europaea oil in rats

Objectives: In the last few decades, therapeutic uses of medicinal compounds present in food as a normal constituent has risen substantially, largely because of their fewer side effects and adequat...

www.tandfonline.com

Black cumin oil containing 5% thymoquinone showed a dose-dependent increase in the acetylcholinesterase inhibition (64.47% inhibition at the dose of 20 µg/ml) which is similar to that of the standard acetylcholinesterase inhibitor donepezil (65.03% inhibition at the dose of 10 µg/ml).

but it does show anti-depressant effect in some rodent studies. maybe because of the GABA-A effects outweighing the serotonin+acetylcholine initially? or that takes longer to show up nearer the end of the study? not sure

the compund "alpha pinene" in nigella sativa does activate serotonin receptors also https://koreascience.kr/article/JAKO200603041158721.pdf

so maybe its effect is similar to SSRIs , where it causes such an extreme overload of serotonin that the brain downregulates the 5-ht2a receptor and upregulates the 5-ht1a over time giving a net benefit effect somehow? idk

 

[June]

Not sure, but black seed oil / nigella sativa might not good to take because of the serotonergic + acetylcholine effects

it elevates serotonin & tryptophan levels a lot according to some studies. https://www.researchgate.net/figure...T-levels-Values-are-mean-SD-n6_fig2_260843200 and inhibits acetylcholinesterase a lot (rasies acetylcholine).

high levels of both of these are common in people with depression

https://www.researchgate.net/publication/24250916_Repeated_administration_of_Nigella_sativa_decreases_5-HT_turnover_and_produces_anxiolytic_effects_in_rats

Increased 5-HT Levels Following Repeated Administration of Nigella sativa L. (Black Seed) Oil Produce Antidepressant Effects in Rats

The seeds of Nigella sativa L., commonly known as black seed or black cumin, and its extracts are used in folk medicine in the Middle East and in Asian countries for the promotion of good health and as a remedy for many ailments. These seeds have many ...

www.ncbi.nlm.nih.gov

Neurochemical and behavioral effects of Nigella sativa and Olea europaea oil in rats

Objectives: In the last few decades, therapeutic uses of medicinal compounds present in food as a normal constituent has risen substantially, largely because of their fewer side effects and adequat...

www.tandfonline.com

but it does show anti-depressant effect in some rodent studies. maybe because of the GABA-A effects outweighing the serotonin+acetylcholine initially? or that takes longer to show up nearer the end of the study? not sure

the compund "alpha pinene" in nigella sativa does activate serotonin receptors also https://koreascience.kr/article/JAKO200603041158721.pdf

so maybe its effect is similar to SSRIs , where it causes such an extreme overload of serotonin that the brain downregulates the 5-ht2a receptor and upregulates the 5-ht1a over time giving a net benefit effect somehow? idk

This is super interesting. Honestly I have damage to my serotonin/gaba system from both SSRI and benzo withdrawals. Funnily enough this isn’t the reason for choosing black seed oil. I’m researching to use for my hydrogen sulfide SIBO issues and possible C.Diff. But if it can undo this residual anxiety and anhedonia from withdrawals. That would be great too. My worry is if it contains sulfur then it has more of potential to exacerbate my gut issues. If it’s clear of sulfur compounds then I’ll use it temporarily till gut issues resolve. But I can’t even begin to experiment since I can’t find much information besides that it contains omega oils and TQ.

 

[June]

Ok this is what I've been able to gather. There are amino acids in Black cumin seeds. Now what does that mean for the oil? that it potentially has sulfur donors in it? For someone who is on a low sulfur diet temporarily, how safe will it be?

https://www.researchgate.net/figure/The-amino-acid-composition-of-black-cumin-seed-protein_tbl3_344206745

 

[Badger]

Will black seed oil be good for chronic muscle inflammation?

 

[June]

Will black seed oil be good for chronic muscle inflammation?

Here's the strangest thing. I started a mild BSO at one teaspoon and there is an uptick of my usual pain around my spine and neck. I wonder if it somehow causes Mast cell activation due to microbial die off.

 

[DonLore]

Not sure, but black seed oil / nigella sativa might not good to take because of the serotonergic + acetylcholine effects

it elevates serotonin & tryptophan levels a lot according to some studies. https://www.researchgate.net/figure...T-levels-Values-are-mean-SD-n6_fig2_260843200 and inhibits acetylcholinesterase a lot (rasies acetylcholine).

high levels of both of these are common in people with depression

https://www.researchgate.net/publication/24250916_Repeated_administration_of_Nigella_sativa_decreases_5-HT_turnover_and_produces_anxiolytic_effects_in_rats

Increased 5-HT Levels Following Repeated Administration of Nigella sativa L. (Black Seed) Oil Produce Antidepressant Effects in Rats

The seeds of Nigella sativa L., commonly known as black seed or black cumin, and its extracts are used in folk medicine in the Middle East and in Asian countries for the promotion of good health and as a remedy for many ailments. These seeds have many ...

www.ncbi.nlm.nih.gov

Neurochemical and behavioral effects of Nigella sativa and Olea europaea oil in rats

Objectives: In the last few decades, therapeutic uses of medicinal compounds present in food as a normal constituent has risen substantially, largely because of their fewer side effects and adequat...

www.tandfonline.com

but it does show anti-depressant effect in some rodent studies. maybe because of the GABA-A effects outweighing the serotonin+acetylcholine initially? or that takes longer to show up nearer the end of the study? not sure

the compund "alpha pinene" in nigella sativa does activate serotonin receptors also https://koreascience.kr/article/JAKO200603041158721.pdf

so maybe its effect is similar to SSRIs , where it causes such an extreme overload of serotonin that the brain downregulates the 5-ht2a receptor and upregulates the 5-ht1a over time giving a net benefit effect somehow? idk

This seems like missing the forest from the trees, black cumin has been used for centuries so it must do something good, + so many studies showing benefit in multiple diseases + so many anecdotes about it. People here too often fixate on small details like how some molecule activates some receptor subunit, but human biology is infinately more complex. Only thing that matters is the effect it actually has on a person