Thymoquinone, Black Cumin: Peat Mentioned In Interview

[narouz]

In the Nitric Oxide interview with The Herb Doctors,
Peat talked a lot about Methylene Blue,
another of the quinones.

I believe it was when a caller asked about
other similar, natural substances that suppress nitric oxide
that Peat mentioned something called Black Cumin.

In looking about it seems there are a couple of different plants going by that name:
-Bunium bulbocastanum, similar to caraway in shape
-Nigella sativa, also called kalonji or nigella, and more common in the West
http://en.wikipedia.org/wiki/Black_cumin

I think it is the latter plant which Peat was referring to,
nigelia sativa,
because Peat also said in that interview that the Black Cumin he was referring to
contained thymoquinone,
and the nigelia sativa plant's seed does contain thymoquinone.
http://en.wikipedia.org/wiki/Thymoquinone
(though that wiki entry also notes another different kind of plant
which contains thymoquinone.)

Here are a few studies about thymoquinone:

http://www.ncbi.nlm.nih.gov/pubmed/12433061

http://www.ncbi.nlm.nih.gov/pubmed/17236176

http://www.ncbi.nlm.nih.gov/pubmed/20561950

http://www.ncbi.nlm.nih.gov/pubmed/23376567

http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/398.4

Just checking around for what forms it comes in,
if it can be bought, etc,
I came up with these sites,
none of which am I endorsing or not endorsing or whatever...

http://www.phytoextractum.com/buy-thymoquinone-99-nigella-sativa-l-isolate

http://www.sigmaaldrich.com/catalog/product/aldrich/274666?lang=en&region=US

...and then it is sold as Black Cumin Seed Oil...

http://www.amazon.com/dp/B009E7SO1M/?tag=rapefo-20

http://www.amazon.com/dp/B0048DO0JM/?tag=rapefo-20

...but it is a seed oil so...I might be afraid of the PUFA...

Just wanted to open a discussion about this quinone.
Peat discusses them often
and we've had threads on some of them here:
-Pau D'Arco
-the tetracyclines
-methylene blue
-vitamin K
-Cascara Sagrada, I think
I think there are others I'm forgetting at the moment....

 

[narouz]

I saw that there is a transcription of that interview on the forum.
Here is the bit about "Black Cumin."
(The transcript incorrectly labels the remarks as coming from HD, Herb Doctors,
but I just listened to the interview and it was without a doubt Peat speaking).

Peat: Recently people are talking about an Asian herb, I think one of the names is Black cumin, but it contains thymol quinone. And the quinones are, I think, the essential; model of the protective pro-oxidant stabilising chemical, and thymol quinone is considered to be a very powerful anti-inflammatory. And I suspect that it will turn out to be acting against excess nitric oxide.

I think the transcription may also be a tad off
in that I think Peat was actually saying "thymoquinone"
rather than thymol quinone....

 

[mas]

Anticancer Activities of Nigella Sativa (Black Cumin)
Afr J Tradit Complement Altern Med. 2011; 8(5 Suppl): 226–232

Nigella sativa has been used as traditional medicine for centuries. The crude oil and thymoquinone (TQ) extracted from its seeds and oil are effective against many diseases like cancer, cardiovascular complications, diabetes, asthma, kidney disease etc. It is effective against cancer in blood system, lung, kidney, liver, prostate, breast, cervix, skin with much safety. The molecular mechanisms behind its anticancer role is still not clearly understood, however, some studies showed that TQ has antioxidant role and improves body's defense system, induces apoptosis and controls Akt pathway. Although the anti-cancer activity of N. sativa components was recognized thousands of years ago but proper scientific research with this important traditional medicine is a history of last 2∼3 decades. There are not so many research works done with this important traditional medicine and very few reports exist in the scientific database.


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252704/

________________________________

Enhancement of anti-inflammatory activity of Aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation.

Aloe vera (Asphodeloideae) is a medicinal plant in which useful secondary metabolites are plentiful. Among the representative secondary metabolites of Aloe vera are the anthraquinones including aloe emodin and chrysophanol, which are tricyclic aromatic quinones synthesized via a plant-specific type III polyketide biosynthesis pathway. …

http://www.ncbi.nlm.nih.gov/pubmed/24358188

______________________________________

Thanks Narouz for that nice summary with links!!!

There are so many healing herbs that ancient cultures knew about and this knowledge is hidden and marginalized in this industrial/military/medical system that we live in.

So far I have tried:

Cascara sagrada: good for keeping regular, but it helps me with digestion and keeping gut muscles relaxed. My husband can take 2 400 mg tablets with no runs. I can only do around 200 mg.

Black cumin oil: We both tried this and there is a nice warm felling from the gut to the intestines. It tastes awful, but what I do is place 1 teaspoon in 4 oz. water and drink it quickly followed by a glass of oj. (make sure that your oil comes in a dark glass bottle for freshness. You can also purchase black cumin seeds.)

Aloe vera: We live in a warm climate and are staring to grow our own and you can make healing tonics from this. Loads of info on youtube.

https://www.youtube.com/watch?v=kTHnOM4k5js

__________________


I use all these herbs for a while and then I stop and then go back. I am still working out dosages.



 

[narouz]

mas-
Yes, I want to try the Black Cumin.
With the aloe vera...
the quinone in that is emodin.
I get confused...is that the same quinone that is in Cascara Sagrada?

I have found that my ability to tolerate Cascara changes.
At some times I've been able to take 400mg twice a day.
Now I'm like you...only 200mg.

I guess with the Black Cumin I'll get the capsules
so I won't have to taste it. :)

 

[ken]

A few years ago on a tour in India I photographed a booth in a market that said "Kalonji Most Effective Remedy For All Diseases". I remember sending the photo to a friend and saying " We better get in on the ground floor of this".

 

[narouz]

Another of the quinones I was trying to remember, above, is
COQ-10
http://en.wikipedia.org/wiki/Coenzyme_Q10

Somewhere here,
haidut provided a more complete listing of quinones.
I'll try to find that.
There are some quinones that aren't good for health--even dangerous.
For instance that antibiotic that has fluorine in it...
Ciprofloxacin.
I guess it is not really a quinone,
but rather a quinolone.

I have wondered if haidut should make a new concoction called Quinodol or something.
It would be a mixture of all the appropriate quinones... :)

 

[javacody]

Another of the quinones I was trying to remember, above, is
COQ-10
http://en.wikipedia.org/wiki/Coenzyme_Q10

Somewhere here,
haidut provided a more complete listing of quinones.
I'll try to find that.
There are some quinones that aren't good for health--even dangerous.
For instance that antibiotic that has fluorine in it...
Ciprofloxacin.
I guess it is not really a quinone,
but rather a quinolone.

I have wondered if haidut should make a new concoction called Quinodol or something.
It would be a mixture of all the appropriate quinones... :)

I would be onboard with this!

What about gummy quinone candies? Then I could give them to my kids, too.

 

[narouz]

Another of the quinones I was trying to remember, above, is
COQ-10
http://en.wikipedia.org/wiki/Coenzyme_Q10

Somewhere here,
haidut provided a more complete listing of quinones.
I'll try to find that.
There are some quinones that aren't good for health--even dangerous.
For instance that antibiotic that has fluorine in it...
Ciprofloxacin.
I guess it is not really a quinone,
but rather a quinolone.

I have wondered if haidut should make a new concoction called Quinodol or something.
It would be a mixture of all the appropriate quinones... :)

I would be onboard with this!

What about gummy quinone candies? Then I could give them to my kids, too.

Yeah, I've wondered what haidut knows about what might happen
when the (appropriate) quinones are taken together, at the same time.
Maybe they might have some kind of synergistic action?
Or maybe something bad?

I've thought about cycling my quinones, one each day.
Or then maybe taking a blend, together...
These are mysteries only haidut can penetrate. :)

 

[mas]

That is an interesting question about if the different individual herbs do work together with greater benefits.

This might be a good question for the Herb Doctors!

 

[narouz]

http://www.if-pan.krakow.pl/pjp/pdf/2011/3_660.pdf

Thymoquinone produced antianxiety-like effects
in mice through modulation of GABA and NO
levels

I just bought some "Black Seed Oil" and took a capsule.
I kinda forgot about that and later
wondered why, on a couple of occasions, like when I burped,
that I tasted the spice thyme....

 

[mas]

Abstract:

Pre-treatment with methylene blue enhanced the antianxiety effect of thymoquinone in both unstressed and stressed mice.

____________________________________


Looks like MB and black cumin work well together!

 

[narouz]

Abstract:

Pre-treatment with methylene blue enhanced the antianxiety effect of thymoquinone in both unstressed and stressed mice.

____________________________________


Looks like MB and black cumin work well together!

That's cool.
I'm taking both,
and also K2 and COQ10 and Pau D'Arco.
Quinone blow-out.

 

[javacody]

Narouz, noticing anything from that?

 

[narouz]

Narouz, noticing anything from that?

Honestly, it would be hard to say.
I've been taking the MB and Pau D'Arco for a while now,
and have noticed good improvements.
Just started adding in the other quinones recently.
Nothing back though... :)

 

[javacody]

When I started MB, I noticed it initially, but after a week or so, it seemed to stop working.

 

[narouz]

...I noticed it initially.....

We probably need to specify what we're meaning by "it".

For me,
I've been taking MB in pretty low dosages (micrograms to low millis).
I think I notice a slight mental accuity thing,
and maybe a slight tonic thing.
But the improvements I was talking about earlier
weren't of the psychotropic sort (if that's the right word).
I've added many other variables than just MB,
so hard for me to say anything scientific,
but I think the MB helped my metabolism and
just because I can't resist throwing in ghastly details,
I think it may'be also helped disappear the weird little bumps around my anus
that had been there for about half a year or more.
And helped my bowels in general.
And this scratch inside my nose
that never would heal for a couple of years...
it's not completely gone, but like 90% gone.

Those are the sorts of improvements I was talking about, java.

 

[javacody]

I was talking about an increase in energy and mental clarity.

Those are some wild improvements you had!

You were taking it internally? How do you dose it?

 

[peatra]

I always wondered what Peat would think of Black Cumin oil. I think it has a lot of PUFA's. It has a really good effect on my skin - I always look glowy the morning after I apply it at night. I've tried a lot of oils and no other oils have such an effect.

 

[Peata]

That's cool.
I'm taking both,
and also K2 and COQ10 and Pau D'Arco.
Quinone blow-out.

Curious what you are taking Pau D'arco for. I am going to start it over the weekend. Was hoping it will help a chronic cough.

 

[ddjd]

Would black seed oil/ nigella sativa be ok if taken with vitamin E to counteract the PUFA