Serotonin Antagonists As Treatment For IBD (Chron's UC, Etc)

haidut

Member
Joined
Mar 18, 2013
Messages
17,435
Location
USA / Europe
It is not common knowledge in research (but not clinical) circles that serotonin is the major cause of the so-called "irritable bowel syndrome" (IBS). As such, there are several large clinical trials using TPH inhibitors to lower serotonin synthesis and thus cure the condition. It is also known that the so-called "inflammatory bowel disease" (IBD) conditions like Chron's and ulcerative colitis (UC) form a continuous spectrum extending from IBS, which means IBS is often a "gateway" disease to developing IBD. This suggests that anti-serotonin drugs should help IBD as well, but that leap of "faith" has not been done yet. The good news is that the role of serotonin in IBD is acknowledged and there are companies pushing in that direction. This news piece shows that blocking the 5-HT7 receptor is probably a viable pathway for curing IBD. Drugs that act as 5-HT7 antagonists include bromocriptine, lisuride, metergoline and of course some more selective ones like the one patented by Temple University below. Unfrotunately, contrary to what medicine claims, often the more selective a drug is the more systemic its side effects are. The older and tested drugs above should be a much safer (and definitely cheaper) alternative.

School of Pharmacy launches IBD treatment startup | Temple Now
"...“This gave us a clear pathway forward for a promising drug discovery project,” said Blass, an assistant professor of medicinal chemistry. “Our compounds are very specific for the target [5-HT7 receptors], possess excellent drug-like properties, and are covered in patent applications, so we immediately started looking for funding.” “We hypothesize that 5-HT7 receptors and serotonin are key to the progression of GI inflammation associated with IBD,” said Canney. “By blocking the receptors, the inflammatory signals produced by serotonin binding will be reduced. No other treatments for IBD target this mechanism of action.”
 

jaa

Member
Joined
Dec 1, 2012
Messages
1,035
For someone with UC, would they see benefits from metergoline if taken topically?
 

Pointless

Member
Joined
Apr 13, 2016
Messages
927
I have Crohns disease, and Cyproheptadine is very effective as I've said before. Cypro is a better bet than most drugs in terms of suppressing diarrhea with fewer side effects but Metergoline is worth a try.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,435
Location
USA / Europe
@haidut I see you mention bromocriptine, lisuride etc do you think cyproheptadine would be as effective of those for IBS, UC and IBD?

It should be, but there are no direct studies with it. The only one that comes close is on functional GI disorders in children and it was very effective. So, I guess we can say it has evidence for IBS but I would not know what the proper dose would be for IBD. Doesn't hurt to try though, at the 2mg doses daily Peat recommends for more serious inflammatory conditions.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,435
Location
USA / Europe
@haidut Okay thank you. What do you think about niacinamide being used for inflammatory bowel issues? I've seen posts from you saying it lowers serotonin could this be another potential use in your opinion?

The earlier post does not say it lowers serotonin - it acts as serotonin antagonist. I guess it would be interesting to try especially given its anti-inflammatory effects as well.
 
L

lollipop

Guest
The earlier post does not say it lowers serotonin - it acts as serotonin antagonist. I guess it would be interesting to try especially given its anti-inflammatory effects as well.
I tried 1.5 gms for a few days and it "anecdotally" helped. I do not have hard data to prove it. I learned it from reading an @TubZy comment speaking about it.
@haidut @raypeatclips
 

raypeatclips

Member
Joined
Jul 8, 2016
Messages
2,555
I tried 1.5 gms for a few days and it "anecdotally" helped. I do not have hard data to prove it. I learned it from reading an @TubZy comment speaking about it.
@raypeatclips

Thanks for the mention, Lisa. What were your specific bowel symptoms that niacinamide helped with? I have seen Tubzy's comments about niacinamide before as well, but I thought they were to do with sluggish digestion, rather than inflamed and painful bowels, and I am cautious not to inflame them further.
 
L

lollipop

Guest
Thanks for the mention, Lisa. What were your specific bowel symptoms that niacinamide helped with? I have seen Tubzy's comments about niacinamide before as well, but I thought they were to do with sluggish digestion, rather than inflamed and painful bowels, and I am cautious not to inflame them further.
I used it for reflux like burn and inflammation in stomach. I used lysine for lower bowel inflammation. Both really helped along with digestive enzymes. In fact I only used these 3 and am sooooo much better - actually symptom free and healthy bowel functioning - several times a day. Excuse me if tmi...
 

raypeatclips

Member
Joined
Jul 8, 2016
Messages
2,555
I used it for reflux like burn and inflammation in stomach. I used lysine for lower bowel inflammation. Both really helped along with digestive enzymes. In fact I only used these 3 and am sooooo much better - actually symptom free and healthy bowel functioning - several times a day. Excuse me if tmi...

Not tmi at all don't worry. I think I missed something, you said you only used these 3, what was the third? Lysine, niacinamide and something else?
 

johnwester130

Member
Joined
Aug 6, 2015
Messages
2,831
this is damm disturbing.

A popular youtube vlogger, Hannah Witton, had her colon removed and is just casually blogging about it.

It was really shocking, this person just makes regular videos about life and then just announce her colon was removed.
 

LCohen

Member
Joined
Dec 31, 2017
Messages
257
Ketotifen, Ondansetron, Cyproheptadine.

These will greatly reduce your IBS.

- Ketotifen is an endotoxin/TLR4 antagonist. Some kind of antibacterial, antibiotic effect it has on gut.
- Ondansetron is an antagonist for 5HT3 receptor. It makes digestion longer and healthier.
- Cypro as you know is a win-win drug. Reduces overall serotonin, cortisol, gut inflammation.. It's a must.

Bromocriptine also helped me. Especially reduced my hypothyroid and digestion problems. Reducing prolactin can be benefical in this situation.
 

Dobbler

Member
Joined
Jun 19, 2016
Messages
581
this is damm disturbing.

A popular youtube vlogger, Hannah Witton, had her colon removed and is just casually blogging about it.

It was really shocking, this person just makes regular videos about life and then just announce her colon was removed.
Why is it disturbing to you? Because removing colon is not wise in any case and there are more natural solutions available?
 

Mat_Eire

Member
Joined
Oct 18, 2016
Messages
18
Ketotifen, Ondansetron, Cyproheptadine.

These will greatly reduce your IBS.

- Ketotifen is an endotoxin/TLR4 antagonist. Some kind of antibacterial, antibiotic effect it has on gut.
- Ondansetron is an antagonist for 5HT3 receptor. It makes digestion longer and healthier.
- Cypro as you know is a win-win drug. Reduces overall serotonin, cortisol, gut inflammation.. It's a must.

Bromocriptine also helped me. Especially reduced my hypothyroid and digestion problems. Reducing prolactin can be benefical in this situation.

Which dsage of bromo did u use and how long, rio?It helps my IBS greatly but many people complain agaisnt it and i also have nausea from it. I take 2,5 mg daily. The lower dosage.
 

LCohen

Member
Joined
Dec 31, 2017
Messages
257
Which dsage of bromo did u use and how long, rio?It helps my IBS greatly but many people complain agaisnt it and i also have nausea from it. I take 2,5 mg daily. The lower dosage.
2-3 weeks. First week 2.5 mg then started to tolerate it and upped to 5 mg. Then again it gave me terrible headaches and stopped.
 

inurendotoxin

Member
Joined
Jul 19, 2018
Messages
109
Location
UK
I have Crohns disease, and Cyproheptadine is very effective as I've said before. Cypro is a better bet than most drugs in terms of suppressing diarrhea with fewer side effects but Metergoline is worth a try.

Is this Idealabs cypro? How do you dose/take it out if interest?

I also have chrons but looking not to go back to immunosuppressants if I can help it.
 
Similar threads
Thread starter Title Forum Replies Date
GutFeeling Benzodiazepines May Be Strong Serotonin Antagonists. Are They Really That Dangerous? Scientific Studies 59
Momado965 Natural Serotonin Antagonists Supplements, Pharmaceutical Drugs 2
tankasnowgod Clif High's Alien Insect Invasion LARP, And Why We Need Military Grade Serotonin Antagonists Political Talk, Alternative World Theories 8
L Risk Of Fibrosis With Serotonin Antagonists Pharmaceutical Drugs 33
M Serotonin Antagonists Cortisol, Serotonin, Histamine 18
T Ranked Serotonin Antagonists And Anti-Inflammatories Health 8
ddjd 4 Natural Serotonin Antagonists Cortisol, Serotonin, Histamine 15
haidut Serotonin Antagonists As Therapy For Alzheimer Disease Scientific Studies 12
Koveras Serotonin Antagonists (1984) Articles 4
haidut Progesterone, Testosterone, Allopregnanolone Are Serotonin Antagonists Scientific Studies 24
haidut Serotonin Antagonists Extend Lifespan, SSRI Dramatically Shorten It Scientific Studies 7
haidut Serotonin antagonists (could) prevent / treat osteoporosis Scientific Studies 0
A Octreotide Inhibits GH, Serotonin, Prolactin, TSH, Insulin Supplements, Pharmaceutical Drugs 0
Q Is Vitamin D induced serotonin syndrome possible? Please hear me out... Ask For Help or Advice 50
Mito Serotonin Pathway in Cancer Cancer 1
deliciousfruit I Think High Serotonin Is Holding Me Back Ask For Help or Advice 9
N The "safest" drug to increase serotonin Mental Issues 19
Mito Serotonin receptor 4 in the hippocampus modulates mood and anxiety Articles & Scientific Studies 0
Hans Anti-serotonin stack for more energy and well-being Articles & Scientific Studies 15
Mauritio 10-methoxy-harmalan ,an anti-serotonin chemical? IdeaLabs 34
Lokzo Vitamin B6 Increases Serotonin, Regardless of Serotonin Levels - PUBMED Supplements, Pharmaceutical Drugs 2
GelatinGoblin Low-Moderate sugar meal with no Protein, Serotonin inducing? Ask For Help or Advice 5
Mito Serotonin is elevated in COVID- 19-associated diarrhoea Miscellaneous Health Discussions 39
Atma Ray Peat Interview #30: LSD, Serotonin, and Hallucinations | PUFA and Lipofuscin | Strategy of Tension | William Blake Interviews 4
haidut Serotonin promotes (futile) patience and (false) faith in future rewards Scientific Studies 19
haidut Serotonin (and SSRI drugs) can cause anxiety and PTSD Scientific Studies 0
haidut Serotonin may cause schizophrenia, Parkinson, and Alzheimer diseases Scientific Studies 2
deliciousfruit cyproheptadine increasing serotonin? Cyproheptadine 23
GorillaHead Is the key to procrastination patience? And is serotonin the key patience? Mental Issues 13
Lokzo This Is How The Carnivore Diet Lowers Serotonin... Diet, Recipes 7
Mauritio Serotonin Depletion Amplifies Distinct Human Social Emotions As A Function Of Individual Differences Scientific Studies 4
Lokzo Do You Have Too Much Serotonin? Miscellaneous Health Discussions 0
DANIEL A High Serotonin Society | Morning Routines, Self-Improvement, Habit Tracking Miscellaneous 1
Lokzo Understand Your Serotonin: What Is Serotonin & How Is It Made? Cortisol, Serotonin, Histamine 3
Lokzo The Expanded Biology Of Serotonin Scientific Studies 0
pauljacob Is Serotonin Good Or Bad? Supplements, Pharmaceutical Drugs 3
haidut Irritable Bowel Syndrome (IBS) Caused By Histamine And Serotonin Scientific Studies 3
M Brain Supplement Recommendations For People With Serotonin Sensitivity Ask For Help or Advice 2
N Girlfriend And I Took LSD And She Got Terrible Stomach Aches - Serotonin/dopamine? Cortisol, Serotonin, Histamine 16
A Serotonin And Diarrhea? Ask For Help or Advice 3
MaxVerstappen Microdosing Mushrooms To Reduce Serotonin Autism 36
Amazigh The Serotonin Receptors: Comparing The Binding Affinity Of 5 Psychedelics Scientific Studies 1
M Does "improving" Serotonin Receptors Help Or Hinder Serotonin Sensitivity? Ask For Help or Advice 5
haidut Prenatal Stress Ups Serotonin, Which Causes Autism And Mental Disease In Offspring Scientific Studies 0
Energizer Ray Peat Interview What's So Happy About Serotonin? Butter Living (8/6/2020) Interviews 6
David PS What's So Happy About Serotonin? With Ray Peat (Butter Living Podcast) Interviews 0
metabolizm The Varicocele: Elevated Serotonin And Infertility (1980) Scientific Studies 9
D Possible Ways To Lower Serotonin In Young Children Autism 10
mrchibbs New Christopher Walker Documentary On Serotonin Health 3
Hgreen56 Hot Foods Or Drinks Makes Me Tired, Hot Temperature Increase Serotonin? Diet 0

Similar threads

Top