antagonist

  1. haidut

    Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

    It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects...
  2. haidut

    A Proposed Anabolic Mechanism Of Tribulus Terrestris (TT)

    Some people on the forum like @Wagner83 myself and a few others have tried the infamous herb TT with the hope of raising androgens and improving body composition. Despite Wikipedia bashing TT and raising doubts about its effectiveness, there is plenty of evidence from human trials shows the herb...
  3. haidut

    The Benefits Of Fasting Are Due To Lowering Endotoxin (LPS), Not Less Calories

    As many of you know, the argument for/against fasting has been raging on the forum for several years at this point. While Ray has spoken several times favorably about potentially skipping a meal or two, he has repeatedly said that chronic fasting is not something he recommends due to its...
  4. haidut

    Pregnenolone Is A (functional) Estrogen Antagonist

    About 2 years ago I posted a thread on the antagonism of pregnenolone to estrogen. Pregnenolone Is An Estrogen Antagonist That claim was from a study, which itself referenced an old French study from 1950. I asked @burtlancast to find it and he was able to trace it to a hardcopy of the French...
  5. haidut

    PUFA Required/essential For Cancer; Stearic Acid Is A PUFA Antagonist & Anti-cancer

    Two studies showing that PUFA (linoleic) acid is essential for cancer development. As the studies show, cancer cells accumulate large quantities of oleic acid and the saturation index (SI) - i.e. ratio of stearic/oleic acids in erythrocytes (RBC) is very low in cancer. This SI can also be used...
  6. haidut

    Successful Antidepressant Drugs Are Glucocorticoid Antagonists

    Peat was asked a few times about his opinion on SSRI drugs and he said that 1) he does not recommend them because they are systemically serotonergic, and 2) their mechanism of action is really not what big pharma would have us believe. Since then, SSRI drugs that have been shown to actually work...
  7. haidut

    Exercise + Fasting Is Stress, Causes Obesity And IR, And Requires Cortisol Blockade To Reverse

    I think this thread will ring true for all people who at some in their lives exercised in order to lose weight. Just like fasting, it works great in younger age (<30) but it really masks a bigger metabolic problem and of course badly backfired in the long run. Exercise is a forced/stressed...
  8. haidut

    Blocking The Endotoxin (TLR4) Receptor May Protect From Ebola Lethality

    The connection between the "flu" and endotoxin has been explored at length by Peat. However, recent evidence has accumulated that quite a few other viruses and the terrible infections they cause may me mediated either by the endotoxin load they increase or by the viruses themselves activating...
  9. haidut

    PUFA Is Estrogenic And Androgen/Progesterone Antagonist

    As Peat mentioned many times and I discussed on Danny Roddy's shows, PUFA is a powerful endocrine disruptor. As such, it has direct effects on steroids and expression of steroids receptors in cells that go beyond its metabolism into the inflammatory mediators (even though those amplify the...
  10. haidut

    Serotonin Antagonists As Treatment For IBD (Chron's UC, Etc)

    It is not common knowledge in research (but not clinical) circles that serotonin is the major cause of the so-called "irritable bowel syndrome" (IBS). As such, there are several large clinical trials using TPH inhibitors to lower serotonin synthesis and thus cure the condition. It is also known...
  11. haidut

    Pregnenolone Is A Potent Aldosterone Antagonist (antimineralocorticoid)

    Ray has written a number of articles on the hypertension, heart and kidney failure, eclampsia, and CVD in which he describes the central role of aldosterone in the pathogenesis of these conditions. Aldosterone antagonists (antimineralocorticoid) are mainstream therapy for heart failure and...
  12. haidut

    The Anti-cortisol Mechanism Of Progesterone

    I just posted the thread on the anti-cortisol mechanism of pregnenolone. The Anti-cortisol Mechanism Of Pregnenolone As I mentioned in that thread, the Peat has been saying that both pregnenolone and progsterone have anti-cortisol effects, however people have been questioning those statements...
  13. haidut

    The Anti-cortisol Mechanism Of Pregnenolone

    One of the recurring arguments on this forum is whether pregnenolone and progesterone (being technically precursor to the glucocorticoids) raise or lower cortisol levels, and whether they have effects opposing or promoting those of the glucocorticoids. The argument advanced by a few people here...
  14. haidut

    5α-Dihydroprogesterone (5α-DHP) Is More Effective Than Progesterone As Estrogen Antagonist

    The study below showed that the steroid 5α-Dihydroprogesterone (5α-DHP) is more effective that progesterone in decreasing the levels of estrogen receptor and can deliver the same result at quite low doses. The HED for 5α-DHP to achieve 75% inhibition of estrogen receptor levels were just...
  15. haidut

    Systemic Sclerosis (scleroderma) May Be Due To Endotoxin; Blocking TLR4 Can Treat It

    In a recent interview Peat explained the connection between endotoxin, hypothyroidism, and rheumatoid arthritis. I recently posted a study claiming that chronic activation of the endotoxin receptor TLR4 synergizes greatly with iron and is probably a causative factor in many degenerative...
  16. haidut

    Glycine Is An Endotoxin (TLR4) Antagonist

    We can now add glycine to the substances that inhibit endotoxin or its effects. The endotoxin antagonism probably explains a good deal of glycine's protective effects on the liver from all sorts of assaults, but especially ethanol/alcohol (which is a known TLR4 agonist). The in-vivo study used a...
  17. haidut

    The Serotonin Receptor 5-HT2B Is Required For Cancer; Can Be Blocked

    I think this study should be sent to every pharma executive and brainwashed whitecoat who claims that serotonin is a good hormone promoting happiness and health. Actually, pharma companies have no illusions and know very well what's going on. Hence, the recent acquisition of Pfizer to the...
  18. haidut

    Fluoride In Tap Water Could Be A Causative Factor In Diabetes

    While the public health authorities continue their mantra on the "benefits" of fluoride for teeth and bone health, there are quite a few research groups that have been producing solid evidence to the contrary. As many of you know, fluoride is a proven thyroid inhibitor. As such, it is expected...
  19. haidut

    Vitamin A (retinol) Is Endotoxin (LPS / TLR4) Antagonist

    Another one in the series of endotoxin antagonism featuring so far vitamins D and B2. Vitamin B2 (riboflavin) Is Endotoxin Antagonist Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections Vitamin D Is Endotoxin (LPS / TLR4) Antagonist, May Treat LPS-linked...
  20. haidut

    Vitamin B2 (riboflavin) Is Endotoxin (LPS / TLR4) Antagonist

    This is just a follow up on the recent post on both riboflavin and vitamin D. Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections https://raypeatforum.com/community/threads/vitamin-d-is-endotoxin-lps-tlr4-antagonist-may-treat-lps-linked-conditions.12060/...
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