Serotonin, SSRI drugs may be the cause of IBD, Parkinson's, diabetes, etc.

[haidut]

A great new study that points the finger straight at serotonin (5-HT). It has been known since the 1940s that not only is 5-HT produced predominantly in the GI tract, but also that elevated serotonin levels are causally linked to a plethora of chronic conditions, especially various inflammatory bowel diseases (IBD) such as Crohn's, ulcerative colitis (UC), irritable bowel syndrome (IBS), and even cancer (carcinoid tumors). However, that knowledge was gradually sidetracked starting in the mid 1960s when various government agencies realized that anti-serotonin drugs like LSD were making people "non-compliant" (which was later officially codified as a mental illness called "oppositional-defiant disorder"), while serotonergic drugs made animals (and the unwitting humans on which they were tested) pliable, obedient, and generally dumb. As such, massive amounts of money was poured into serotonergic drug development, culminating with the regulatory approval of the so-called SSRI drugs, which remain to this day the most widely prescribed psychotropic drugs in the "developed" world. However, selling a lot of SSRI drugs is not really compatible with the idea that 5-HT is highly detrimental to health, even if that detrimental 5-HT effect is localized to the GI tract (hint: it is not). Thus, the campaign of censoring, concealing, and even outright fraud in regards to the real effects of serotonin has not only not stopped since it first started in the mid-1960s, but in fact rages with bigger fervor today considering how much more (money) is at stake nowadays. Nonetheless, the old published evidence of the detrimental effects of 5-HT is still available and every once in a while a study comes along that cites that old evidence and adds new one of its own. Namely, the study below demonstrates that 5-HT is a major causal factor in IBD, and perhaps a host of other issues seemingly unrelated to the GI tract. Worse, the study cites direct evidence that the very usage of those SSRI drugs is likely a causal factor in all of these disease (duh!). Those other conditions include Parkinson disease (PD), Alzheimer Disease (AD), Multiple sclerosis (MS), theumatoid arthritis (RA), Lupus, diabetes, osteoporosis, hypogonadism, mental illness, cancer, etc since all of them have been found to be at least partially caused by impaired autophagy, and the study below demonstrates that a major mechanism of 5-HT's pathological role is by impairing autophagy. Now, since 5-HT production in the GI tract largely depends on the production of endotoxin, the study below once again implicates endotoxin/LPS and ultimately the microbiome, as the top-level cause of virtually all chronic diseases. Thus, while using serotonin antagonists would likely be therapeutic for any of the above mentioned conditions (as the study below actually demonstrated), a more systemic approach would be to simply keep the microbiome in check by eating easily digestible food and ingesting sufficient amount of insoluble fiber daily, or periodically taking antibiotics and/or charcoal, as all of those approaches ultimately result in lower endotoxin/LPS and/or bacterial biomass in the GI tract. Btw, while endotoxin/LPS is the major factor driving 5-HT production in the GI tract, there are other factors that we should keep in mind. For example, mechanical stress such as twisting, tossing, jerking, vibrating, etc of the intestines can also easily trigger 5-HT production. This is clearly demonstrated by the fact that most long-distance runners (especially at extreme events like marathons/triathlons) experience bouts of diarrhea (a sign of high 5-HT) during those events. In addition, stress (acute or chronic) leads to reduction of blood flow in the GI tract (in order to direct metabolic resources and oxygen to more vital organs like brain and heart), and reduction of blood flow to the GI tract can also easily trigger the production of 5-HT. Finally, while 90%+ of 5-HT is synthesized in the GI tract, the brain can also synthesize 5-HT (from the amino acid tryptophan). Tryptophan uptake into the brain can be increased by lack of sufficient dietary protein, since a number of the other amino acids compete for uptake into the brain with tryptophan and reduction in the supply of those other amino acids leaves tryptophan brain entry unopposed, ultimately resulting in elevated brain 5-HT synthesis. Finally, even protein intake is sufficient, a rise in lipolysis (due to stress, fasting, low-carb diets, etc) displaces tryptophan from albumin (where it is normally bound) and that increase in unbound tryptophan allows it to enter the brain in higher amounts, which also results in increased 5-HT production. TLDR: To limit the risk of any of these chronic diseases - avoid stress (including its more furtive examples like fasting, low-carbing, protein deficiency, etc), eat easily digestible food, and keep your gut as clean/sterile as possible.

AAAS
"... In HT-29 cells, 5-HT–induced reduction in the autophagy proteins LC3-II, Beclin-1, and Atg12-5 and elevation of p-mTOR and p62 were completely reversed by the 5-HT7 receptor antagonist, SB269970 (fig. S5, A and B). In addition, in mouse primary IECs, 5-HT–induced alteration in the autophagy proteins LC3-II and p62 was significantly blocked by the 5-HT3 receptor antagonist tropisetron, 5-HT4 receptor antagonist RS39604, and 5-HT7 receptor antagonist SB269970 (fig. S5, C and D). These findings indicate that although 5-HT impairs autophagy via all three 5-HT receptors expressed on IECs, 5-HT7 receptor might be playing a major role. Together, these findings suggest an important role of 5-HT and its receptors in the regulation of autophagy in IECs."
"...An increase in plasma/serum 5-HT levels is observed in patients with IBD, and the use of selective 5-HT reuptake inhibitors is associated with microscopic colitis (21, 23, 39, 40, 60, 61). In addition, dysfunction in the autophagic process is implicated in the development of intestinal inflammation in patients with IBD"
"...This study is the first to report the important role of the 5-HT–autophagy axis in IECs and its contribution to the regulation of microbiota in relation to susceptibility to intestinal inflammation. Our findings suggest that blocking 5-HT signaling may promote autophagy and alleviate the severity of intestinal inflammation. Given recent reports of impaired autophagy in patients with CD (2, 42) and the established changes in 5-HT production in IBD (20–22), this research sheds light on 5-HT as a novel regulator of autophagy in gut inflammation. These findings may ultimately lead to the discovery of novel therapeutic strategies in intestinal inflammatory conditions such as IBD and other health disorders that exhibit dysregulated autophagy."

Study identifies serotonin as a possible trigger of flare-ups in Crohn's disease
"...A new treatment may be on the horizon for people with a major form of inflammatory bowel disease (IBD) called Crohn's disease, after a McMaster University-led study identified serotonin as a possible trigger of flare-ups. Scientists discovered that increased levels of serotonin hormones prevent gut cells from carrying out autophagy, the routine 'housework' of the gut cleaning out damaged or malfunctioning cellular components. Researchers gleaned their results by analyzing blood and biopsy samples from two groups totalling 18 people with Crohn's disease, comparing them to a matching number of people from two healthy control groups. A mouse model of IBD was also used. Senior author Waliul Khan said the resulting autophagy dysfunction has been implicated in triggering IBDs such as Crohn's disease, as well as other conditions such as diabetes and Parkinson's disease."

 

[Lollipop2]

WoW...the news keeps rolling in. Heavy accusations - wonder if anyone will correlate the jump in use of SSRI’s and the incidence of these diseases over say a 40 year period?

As an n=1, I have seen it many times people with IBD were serious SSRI addicts who would never come off them.

 

[J.R.K]

A great new study that points the finger straight at serotonin (5-HT). It has been known since the 1940s that not only is 5-HT produced predominantly in the GI tract, but also that elevated serotonin levels are causally linked to a plethora of chronic conditions, especially various inflammatory bowel diseases (IBD) such as Crohn's, ulcerative colitis (UC), irritable bowel syndrome (IBS), and even cancer (carcinoid tumors). However, that knowledge was gradually sidetracked starting in the mid 1960s when various government agencies realized that anti-serotonin drugs like LSD were making people "non-compliant" (which was later officially codified as a mental illness called "oppositional-defiant disorder"), while serotonergic drugs made animals (and the unwitting humans on which they were tested) pliable, obedient, and generally dumb. As such, massive amounts of money was poured into serotonergic drug development, culminating with the regulatory approval of the so-called SSRI drugs, which remain to this day the most widely prescribed psychotropic drugs in the "developed" world. However, selling a lot of SSRI drugs is not really compatible with the idea that 5-HT is highly detrimental to health, even if that detrimental 5-HT effect is localized to the GI tract (hint: it is not). Thus, the campaign of censoring, concealing, and even outright fraud in regards to the real effects of serotonin has not only not stopped since it first started in the mid-1960s, but in fact rages with bigger fervor today considering how much more (money) is at stake nowadays. Nonetheless, the old published evidence of the detrimental effects of 5-HT is still available and every once in a while a study comes along that cites that old evidence and adds new one of its own. Namely, the study below demonstrates that 5-HT is a major causal factor in IBD, and perhaps a host of other issues seemingly unrelated to the GI tract. Worse, the study cites direct evidence that the very usage of those SSRI drugs is likely a causal factor in all of these disease (duh!). Those other conditions include Parkinson disease (PD), Alzheimer Disease (AD), Multiple sclerosis (MS), theumatoid arthritis (RA), Lupus, diabetes, osteoporosis, hypogonadism, mental illness, cancer, etc since all of them have been found to be at least partially caused by impaired autophagy, and the study below demonstrates that a major mechanism of 5-HT's pathological role is by impairing autophagy. Now, since 5-HT production in the GI tract largely depends on the production of endotoxin, the study below once again implicates endotoxin/LPS and ultimately the microbiome, as the top-level cause of virtually all chronic diseases. Thus, while using serotonin antagonists would likely be therapeutic for any of the above mentioned conditions (as the study below actually demonstrated), a more systemic approach would be to simply keep the microbiome in check by eating easily digestible food and ingesting sufficient amount of insoluble fiber daily, or periodically taking antibiotics and/or charcoal, as all of those approaches ultimately result in lower endotoxin/LPS and/or bacterial biomass in the GI tract. Btw, while endotoxin/LPS is the major factor driving 5-HT production in the GI tract, there are other factors that we should keep in mind. For example, mechanical stress such as twisting, tossing, jerking, vibrating, etc of the intestines can also easily trigger 5-HT production. This is clearly demonstrated by the fact that most long-distance runners (especially at extreme events like marathons/triathlons) experience bouts of diarrhea (a sign of high 5-HT) during those events. In addition, stress (acute or chronic) leads to reduction of blood flow in the GI tract (in order to direct metabolic resources and oxygen to more vital organs like brain and heart), and reduction of blood flow to the GI tract can also easily trigger the production of 5-HT. Finally, while 90%+ of 5-HT is synthesized in the GI tract, the brain can also synthesize 5-HT (from the amino acid tryptophan). Tryptophan uptake into the brain can be increased by lack of sufficient dietary protein, since a number of the other amino acids compete for uptake into the brain with tryptophan and reduction in the supply of those other amino acids leaves tryptophan brain entry unopposed, ultimately resulting in elevated brain 5-HT synthesis. Finally, even protein intake is sufficient, a rise in lipolysis (due to stress, fasting, low-carb diets, etc) displaces tryptophan from albumin (where it is normally bound) and that increase in unbound tryptophan allows it to enter the brain in higher amounts, which also results in increased 5-HT production. TLDR: To limit the risk of any of these chronic diseases - avoid stress (including its more furtive examples like fasting, low-carbing, protein deficiency, etc), eat easily digestible food, and keep your gut as clean/sterile as possible.

AAAS
"... In HT-29 cells, 5-HT–induced reduction in the autophagy proteins LC3-II, Beclin-1, and Atg12-5 and elevation of p-mTOR and p62 were completely reversed by the 5-HT7 receptor antagonist, SB269970 (fig. S5, A and B). In addition, in mouse primary IECs, 5-HT–induced alteration in the autophagy proteins LC3-II and p62 was significantly blocked by the 5-HT3 receptor antagonist tropisetron, 5-HT4 receptor antagonist RS39604, and 5-HT7 receptor antagonist SB269970 (fig. S5, C and D). These findings indicate that although 5-HT impairs autophagy via all three 5-HT receptors expressed on IECs, 5-HT7 receptor might be playing a major role. Together, these findings suggest an important role of 5-HT and its receptors in the regulation of autophagy in IECs."
"...An increase in plasma/serum 5-HT levels is observed in patients with IBD, and the use of selective 5-HT reuptake inhibitors is associated with microscopic colitis (21, 23, 39, 40, 60, 61). In addition, dysfunction in the autophagic process is implicated in the development of intestinal inflammation in patients with IBD"
"...This study is the first to report the important role of the 5-HT–autophagy axis in IECs and its contribution to the regulation of microbiota in relation to susceptibility to intestinal inflammation. Our findings suggest that blocking 5-HT signaling may promote autophagy and alleviate the severity of intestinal inflammation. Given recent reports of impaired autophagy in patients with CD (2, 42) and the established changes in 5-HT production in IBD (20–22), this research sheds light on 5-HT as a novel regulator of autophagy in gut inflammation. These findings may ultimately lead to the discovery of novel therapeutic strategies in intestinal inflammatory conditions such as IBD and other health disorders that exhibit dysregulated autophagy."

Study identifies serotonin as a possible trigger of flare-ups in Crohn's disease
"...A new treatment may be on the horizon for people with a major form of inflammatory bowel disease (IBD) called Crohn's disease, after a McMaster University-led study identified serotonin as a possible trigger of flare-ups. Scientists discovered that increased levels of serotonin hormones prevent gut cells from carrying out autophagy, the routine 'housework' of the gut cleaning out damaged or malfunctioning cellular components. Researchers gleaned their results by analyzing blood and biopsy samples from two groups totalling 18 people with Crohn's disease, comparing them to a matching number of people from two healthy control groups. A mouse model of IBD was also used. Senior author Waliul Khan said the resulting autophagy dysfunction has been implicated in triggering IBDs such as Crohn's disease, as well as other conditions such as diabetes and Parkinson's disease."

Thanks for posting this @haidut. A hypothesis that I have been considering as of late.
For many years we have heard that marijuana is a gateway drug to more of what are considered detrimental drugs such as cocaine, heroin, meth amphetamine, and as of late OxyContin.
My thoughts are that what if,(and this is based upon observations of people around me). What if you start out with asthma and they give you a glucocorticoid inhaler with instructions,”to just use it as you need it”. Eventually that glucocorticoid is not strong enough for your symptoms so they increase the dose, and the cycle continues, then one day you go to the doctor and they find that you now have high blood pressure so they prescribe an ACE inhibitor and of course reduce your salt intake, so now you take the ACE inhibitor but your using your inhaler more because you have reduced the ACE 2 in your body but your bradykinan levels have risen and your,”asthma” seems worse so you now are using the glucocorticoid more often and not only raising your cortisol levels higher, but also your aldosterone levels due to the reduced salt as well as (I think this might be true) the ACE inhibitors effects upon the RAS. Invariably this rise in these stress hormones will also cause estrogen to rise as well as serotonin due to the stress put on the entire system.
The combination of cortisol (both endogenous and prescribed) and serotonin levels rising feeds into the feelings of anxiety and depression, which they will monitor and try different techniques such as therapy, hypnosis, and of course meditation to relieve these feelings. But as we know these things appear to be mildly and temporarily effective at best. So now they start you on a low dose of SSRI’s,” just to see if it will relieve the anxiety and depression”. This of course just opens up more problems with the above mentioned more serious diseases.
Oh and I almost forgot, they would also recommend that you get some rest and relaxation which is not bad advice, and avoid doing any physical activities that involve lifting or physical movements that aggravate the aches and pains you are experiencing . This of course leads to a sedentary type of life which will feed more cortisol due to muscles not being used and being canabalized and turned to fat which of course upregulates estrogen.
But you might want to get away to somewhere tropical and for that you will of course need a COVID vaccination.

 

[haidut]

Thanks for posting this @haidut. A hypothesis that I have been considering as of late.
For many years we have heard that marijuana is a gateway drug to more of what are considered detrimental drugs such as cocaine, heroin, meth amphetamine, and as of late OxyContin.
My thoughts are that what if,(and this is based upon observations of people around me). What if you start out with asthma and they give you a glucocorticoid inhaler with instructions,”to just use it as you need it”. Eventually that glucocorticoid is not strong enough for your symptoms so they increase the dose, and the cycle continues, then one day you go to the doctor and they find that you now have high blood pressure so they prescribe an ACE inhibitor and of course reduce your salt intake, so now you take the ACE inhibitor but your using your inhaler more because you have reduced the ACE 2 in your body but your bradykinan levels have risen and your,”asthma” seems worse so you now are using the glucocorticoid more often and not only raising your cortisol levels higher, but also your aldosterone levels due to the reduced salt as well as (I think this might be true) the ACE inhibitors effects upon the RAS. Invariably this rise in these stress hormones will also cause estrogen to rise as well as serotonin due to the stress put on the entire system.
The combination of cortisol (both endogenous and prescribed) and serotonin levels rising feeds into the feelings of anxiety and depression, which they will monitor and try different techniques such as therapy, hypnosis, and of course meditation to relieve these feelings. But as we know these things appear to be mildly and temporarily effective at best. So now they start you on a low dose of SSRI’s,” just to see if it will relieve the anxiety and depression”. This of course just opens up more problems with the above mentioned more serious diseases.
Oh and I almost forgot, they would also recommend that you get some rest and relaxation which is not bad advice, and avoid doing any physical activities that involve lifting or physical movements that aggravate the aches and pains you are experiencing . This of course leads to a sedentary type of life which will feed more cortisol due to muscles not being used and being canabalized and turned to fat which of course upregulates estrogen.
But you might want to get away to somewhere tropical and for that you will of course need a COVID vaccination.

I think this is a very reasonable explanation - i.e. "benign" drugs that are mass-prescribed serving as a gateway to becoming hooked on the medical system, with steadily declining health in the process. The PPI drugs are another great example of a "gateway" drug, and are perhaps the most prescribed in developed countries. If you search the forum for PPI you will see just how many studies on their detrimental effects there are. And unsurprisingly, there is a pill/treatment for virtually all of those side effects, and those pills have their own side effects and there are more pills for those and so on ad-nauseam. Considering the PPI drugs are now approved for even infants, the medical/pharma industry has basically ensured it will have an unending and steady supply of clients for as long as people are willing to consume that poison.

 

[Kykeon]

i knew a girl that always took 5-htp as supplement, and she had the worst case of bulimic behavior possible, i did not understand the connections but now i can see how it could be connected.

 

[PhilParma]

Slightly off topic, but since you mentioned LSD; if it's anti-serotonin and makes people non-compliant, then why was/is the CIA so keen on spreading it via the Grateful Dead, using it for mind control experiments, etc.?

 

[haidut]

Slightly off topic, but since you mentioned LSD; if it's anti-serotonin and makes people non-compliant, then why was/is the CIA so keen on spreading it via the Grateful Dead, using it for mind control experiments, etc.?

I don't think the CIA was using it as a mind control tool. It was using it as a truth serum, as some of their own research suggested serotonin promotes lying/slyness while lowering serotonin had the opposite effect. I'd say this is probably a valid hypothesis, but what the CIA did not take into account is that the defectors they used LSD on were all interrogated in obviously very stressful settings (e.g. military installations), often accompanied by torture, so whatever "truth-telling" effects LSD may have got drowned by the instinct for survival and the stress of torture/interrogation. In a social, uninhibited setting, LSD and other anti-serotonin agents probably promote being truthful. It is not a coincidence that "artistic" types are often very blunt and socially "awkward" in public. They tend to have high dopamine / low serotonin and find rigid settings demanding fake and hierarchical behavior abhorrent and will often tell the truth to the embarrassment of everybody around them.

 

[J.R.K]

I think this is a very reasonable explanation - i.e. "benign" drugs that are mass-prescribed serving as a gateway to becoming hooked on the medical system, with steadily declining health in the process. The PPI drugs are another great example of a "gateway" drug, and are perhaps the most prescribed in developed countries. If you search the forum for PPI you will see just how many studies on their detrimental effects there are. And unsurprisingly, there is a pill/treatment for virtually all of those side effects, and those pills have their own side effects and there are more pills for those and so on ad-nauseam. Considering the PPI drugs are now approved for even infants, the medical/pharma industry has basically ensured it will have an unending and steady supply of clients for as long as people are willing to consume that poison.

It is a brilliant strategy and very healthy for the bottom line financially, but it has to come with the price of trading your humanity for wealth when you leave your clients in a chaotic state of health.
On a separate but similar note. I remember when you mentioned what might happen if the spike protein were to enter the nuclei of the cells, a fact that all people in the mainstream maintain as being impossible. But this albeit in vitro demonstrates that indeed this is a real possibility. With horrible potential, as the spike protein seems to down regulate the HEJK repair for DNA, as well as replication.

https://www.naturalnews.com/files/viruses-13-02056-v2.pdf

This too will allow for treatment of many subsequent symptoms but not the root cause in the gene therapy treated.

 

[Nfinkelstein]

Grateful for this post, thank you.

 

[aliml]

5-HT3 receptor antagonist == Metoclopramide, THC , Methylfolate, Dactinomycin, Granisetron, Raloxifene

5-HT4 receptor antagonist == Carbamazepine, Fluoxetine , Methylfolate, Venlafaxine, Silicon Dioxide

5-HT7 receptor antagonist == Metergoline, Lisuride, Fluoxetine, Tunicamycin, Carbamazepine, Tamoxifen

 

[Soren]

Any thoughts of which of the 5-HT's are the most important when it comes to Parkinson's disease?

I'm thinking that a combination of Metergoline and 10-Methoxy-Harmalan along with a dopamine agonist such as Lisuride or rotigotine could be an absolute knockdown combination.

 

['peataphysique]

I don't think the CIA was using it as a mind control tool. It was using it as a truth serum, as some of their own research suggested serotonin promotes lying/slyness while lowering serotonin had the opposite effect. I'd say this is probably a valid hypothesis, but what the CIA did not take into account is that the defectors they used LSD on were all interrogated in obviously very stressful settings (e.g. military installations), often accompanied by torture, so whatever "truth-telling" effects LSD may have got drowned by the instinct for survival and the stress of torture/interrogation. In a social, uninhibited setting, LSD and other anti-serotonin agents probably promote being truthful.

LSD and Sidney Gottlieb

The CIA began to experiment with LSD (lysergic acid diethylamide) under the direction of agency chemist and poison expert Sidney Gottlieb. He believed the agency could harness the drug’s mind-altering properties for brainwashing or psychological torture.

Under the auspices of Project MK-Ultra, the CIA began to fund studies at Columbia University, Stanford University and other colleges on the effects of the drug. After a series of tests, the drug was deemed too unpredictable for use in counterintelligence.

MK-Ultra also included experiments with MDMA (ecstasy), mescaline, heroin, barbiturates, methamphetamine and psilocybin (“magic mushrooms”).

MK-Ultra

www.history.com

It is not a coincidence that "artistic" types are often very blunt and socially "awkward" in public. They tend to have high dopamine / low serotonin and find rigid settings demanding fake and hierarchical behavior abhorrent and will often tell the truth to the embarrassment of everybody around them.

"Mens sana in corpore sano"

For the past 2 decades more and more research is showing that all personality disorders are the result of brain damage. When your brain is functioning, not even optimally, but it's working in a good enough way and is able to provide enough energy so as to have room for complex ethical decisions etc... this also let's you become more self-reliant when it comes to managing emotional self-regulation and other self-object functions (as defined by Kohut et al.) which now are able to be covered without the aid of other people, specially those who can only offer fake nurturing, it follows you won't engage in virtue signalling and other duplicituous activities.

 

[golder]

5-HT3 receptor antagonist == Metoclopramide, THC , Methylfolate, Dactinomycin, Granisetron, Raloxifene

5-HT4 receptor antagonist == Carbamazepine, Fluoxetine , Methylfolate, Venlafaxine, Silicon Dioxide

5-HT7 receptor antagonist == Metergoline, Lisuride, Fluoxetine, Tunicamycin, Carbamazepine, Tamoxifen

Great list, thanks. Did you compile it yourself? Could you list the other serotonin receptors and the respective antagonists? Shocked at Silicon Dioxide.

 

[aliml]

Any thoughts of which of the 5-HT's are the most important when it comes to Parkinson's disease?

In order of importance in Parkinson's disease:

HTR6 == Cocaine, Resveratrol, Scopolamine Hydrobromide, Hyoscine

HTR2B == Fluoxetine, Lisuride, Progesterone, Cyproheptadine, Ritanserin, Bortezomib, Methamphetamine, Resveratrol, Propionaldehyde (Hops plant), Pentanal (Olive oil)

HTR1A == Fluoxetine, Morphine, Nicotine, Pindolol, Desipramine, Physostigmine, Colforsin, Reserpine, Venlafaxine, Magnesium, Cocaine, Clofibrate, Melitten (Honeybee Venom)

HTR3A == Metoclopramide, THC , Methylfolate, Dactinomycin, Granisetron, Raloxifene, Cocaine

HTR2C == Vorinostat, Venlafaxine, Tretinoin (Vitamin A), Nortriptyline, Haloperidol, Cyclosporine, Chlorpromazine, Ritanserin, Mirtazapine, Pilocarpine, Bacopa monnieri

HTR2A == Cinanserin, Metergoline, Streptozocin, Imipramine, Cyproheptadine, Desipramine, Colforsin, Acetaminophen, Tryptamine, Ritanserin, Tobacco Smoke, Fluoxetine, Methiothepin

HTR7 == Metergoline, Lisuride, Fluoxetine, Tunicamycin, Carbamazepine, Tamoxifen, Clozapine, Mianserin, Ritanserin, Ketanserin, Methiothepin, Spiperone, Bromocriptine, Tunicamycin, Venlafaxine

HTR1D == Capsaicin, Amitriptyline, EGCG, Resveratrol, Haloperidol, Clozapine

HTR3B == Capsaicin

HTR5A == Clofibrate, Genistein, Bleomycin

HTR1B == Capsaicin, Acetaminophen, Paroxetine, Resveratrol, Citalopram, Carbamazepine, Colforsin

HTR4 == Carbamazepine, Fluoxetine, Methylfolate

 

[aliml]

Great list, thanks. Did you compile it yourself?

Thanks, no, I just copied!

https://selfdecode.com/gene/htr3a/#!#all-ways-to-decrease-gene https://selfdecode.com/gene/htr4/#!#all-ways-to-decrease-gene https://selfdecode.com/gene/htr7/#!#all-ways-to-decrease-gene

Could you list the other serotonin receptors and the respective antagonists?

View the previous post.

Shocked at Silicon Dioxide.

I think, anti-diarrheal compounds such as bentonite/clay (Silicon Dioxide) are serotonin receptor antagonists!

 

[RenaissanceMan]

I don't think the CIA was using it as a mind control tool. It was using it as a truth serum, as some of their own research suggested serotonin promotes lying/slyness while lowering serotonin had the opposite effect. I'd say this is probably a valid hypothesis, but what the CIA did not take into account is that the defectors they used LSD on were all interrogated in obviously very stressful settings (e.g. military installations), often accompanied by torture, so whatever "truth-telling" effects LSD may have got drowned by the instinct for survival and the stress of torture/interrogation. In a social, uninhibited setting, LSD and other anti-serotonin agents probably promote being truthful. It is not a coincidence that "artistic" types are often very blunt and socially "awkward" in public. They tend to have high dopamine / low serotonin and find rigid settings demanding fake and hierarchical behavior abhorrent and will often tell the truth to the embarrassment of everybody around them.

Where's the evidence that LSD is anti-serotonin? I've brought it up in the past but nobody has shown me anything on it

 

[golder]

Frustrating how Resveratrol and fluoxetine work well in antagonising seratonin but are profoundly anti-peat from a systemic perspective. What do you think is the most comprehensive anti serotonin stack that complements the bioenergetic perspective?

 

[Soren]

In order of importance in Parkinson's disease:

HTR6 == Cocaine, Resveratrol, Scopolamine Hydrobromide, Hyoscine

HTR2B == Fluoxetine, Lisuride, Progesterone, Cyproheptadine, Ritanserin, Bortezomib, Methamphetamine, Resveratrol, Propionaldehyde (Hops plant), Pentanal (Olive oil)

HTR1A == Fluoxetine, Morphine, Nicotine, Pindolol, Desipramine, Physostigmine, Colforsin, Reserpine, Venlafaxine, Magnesium, Cocaine, Clofibrate, Melitten (Honeybee Venom)

HTR3A == Metoclopramide, THC , Methylfolate, Dactinomycin, Granisetron, Raloxifene, Cocaine

HTR2C == Vorinostat, Venlafaxine, Tretinoin (Vitamin A), Nortriptyline, Haloperidol, Cyclosporine, Chlorpromazine, Ritanserin, Mirtazapine, Pilocarpine, Bacopa monnieri

HTR2A == Cinanserin, Metergoline, Streptozocin, Imipramine, Cyproheptadine, Desipramine, Colforsin, Acetaminophen, Tryptamine, Ritanserin, Tobacco Smoke, Fluoxetine, Methiothepin

HTR7 == Metergoline, Lisuride, Fluoxetine, Tunicamycin, Carbamazepine, Tamoxifen, Clozapine, Mianserin, Ritanserin, Ketanserin, Methiothepin, Spiperone, Bromocriptine, Tunicamycin, Venlafaxine

HTR1D == Capsaicin, Amitriptyline, EGCG, Resveratrol, Haloperidol, Clozapine

HTR3B == Capsaicin

HTR5A == Clofibrate, Genistein, Bleomycin

HTR1B == Capsaicin, Acetaminophen, Paroxetine, Resveratrol, Citalopram, Carbamazepine, Colforsin

HTR4 == Carbamazepine, Fluoxetine, Methylfolate

Thanks for this Aliml I would be curious as to what you base this order of importance on. Thanks

 

[RenaissanceMan]

I think, anti-diarrheal compounds such as bentonite/clay (Silicon Dioxide) are serotonin receptor antagonists!

Silicon Dioxide is a TLR4 receptor agonist. Increases endotoxin significantly, which would significantly increase serotonin

 

[aliml]

Thanks for this Aliml I would be curious as to what you base this order of importance on. Thanks

Based on the score of genes interactions with Parkinson's disease.

See the link below!

SelfDecode | Genome Analysis

Use SelfDecode to get personalized health recommendations based on your genes. Get started today with an existing DNA file or order a SelfDecode DNA kit!

selfdecode.com