Serotonin As The Cause Of Acute Pancreatitis

Discussion in 'Scientific Studies' started by haidut, Jul 13, 2016.

  1. haidut

    haidut Member

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    As some of you know, pancreatitis is a condition very common among alcoholics and people on SSRI drugs. When it is acute it can be quite deadly and its incidence has been skyrocketing lately, which concided with rising rates of alcohol abuse among middle-class citizens in the Western world. The drug companies continue to deny that serotonin is involved in the pathology of any GI disease, but quietly they are running trials with inhibitors of TPH as treatment for IBS, IBD, and even some GI cancers.
    This study shows that the activation of the 5-HT2 receptor is crucial for the development of the acute pancreatitis pathology and antagonists at that receptor (cyproheptadine, ritanserin, etc) can successfully treat the condition.

    Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice. - PubMed - NCBI

    "...The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the cerulein-induced hyperenzymemia was attenuated in mice pretreated with p-CPA, a 5-HT depletor, it was exaggerated by the preferential 5-HT2A agonist (DOI), but not by the preferential 5-HT2B agonist (BW723C86) or the preferential 5-HT2C agonist (mCPP). Selective 5-HT2A antagonists (risperidone, spiperone, ketanserin, AMI-193, and MDL 11,939) dose-dependently attenuated the hyperenzymemia; and their potency order, excepting that of ketanserin which has considerable affinity at the 5-HT2C receptor as well, paralleled their reported pKi values at the 5-HT2A receptor. Selective 5-HT2B (SB204741) and 5-HT2C (SB242084) antagonists hardly affected the hyperenzymemia. Although the non-selective 5-HT2A/2B/2C antagonists (metergoline, ritanserin, and methysergide) dose-dependently attenuated the hyperenzymemia, they were relatively less potent compared to their high pKi values at the 5-HT2A receptor. In another set of experiments, risperidone, but not SB204741 and SB242084, dose-dependently reversed the cerulein-induced histological alteration of the pancreas (inflammatory cell infiltration). These results suggest that endogenously released 5-HT activates 5-HT2A receptors to aggravate cerulein-induced pancreatitis. We propose that selective 5-HT2A antagonists may provide a new therapy for acute pancreatitis."
     
  2. Nadine Sokie

    Nadine Sokie New Member

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    Thank you for the info. am going to see a thyroid doc on Aug 10th. Haidut. what test would I have them do to check the pancreace? What other test could i have done? I have had problems for along time now I have hashimoto. Mother died of ovarian cancer at 44 yrs.
     
  3. OP
    haidut

    haidut Member

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    The tests for lipase, amilase and protease will show if there is pancreatic inflammation. There are other tests the doctor can also order but usually these are good as a start.
     
  4. ecstatichamster

    ecstatichamster Member

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    what's a decent Peat-friendly way to treat this?
     
  5. OP
    haidut

    haidut Member

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    You mean, aside from blocking serotonin? I think lowering fat intake and increasing the proportion of SFA should also help. Pancreatitis is similar to hepatitis in the sense that PUFA and alcohol aggravates it and SFA alleviates it. Aspirin may help too.
     
  6. ecstatichamster

    ecstatichamster Member

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