Salicylic acid might be good for the gut health and function

Hans

Member
Joined
Aug 24, 2017
Messages
3,308
Aspirin has been shown to cause intestinal bleeding in some people and that's why they generally avoid aspirin. That can easily be remedied by switching to sodium salicylate or simply salicylic acid.
But this study is not about that. It actually shows that salicylate can be beneficial for the gut, at least in rats. The dose was 50mg/kg/day, with the HED being 7.14mg/kg. That will be around 500mg for a 70kg person.

"ZDF and Zucker lean (ZL) rats were administered a high-fat diet with or without SAL intervention, and their relative rates of diabetes were compared. Our results showed that all rats in the placebo group developed diabetes, whereas only 10% of the SAL-treated rats presented with impaired glucose tolerance (IGT). None of the latter progressed to diabetes. Relative to the untreated rats, SAL lowered plasma glucagon and insulin while improving insulin sensitivity and β-cell function. SAL may protect against hyperglycemia by increasing the microbial diversity, ameliorating gut dysbiosis, restoring intestinal epithelial cell connections, inhibiting endotoxin influx into the blood, and attenuating inflammation. Together, these findings suggest that SAL may be a candidate prophylactic therapy against diabetes. The protective role of SAL may be attributed to its ability to reduce intestinal inflammation and improve gut dysbiosis."
 

Mito

Member
Joined
Dec 10, 2016
Messages
1,936
Chris Masterjohn thinks salicylate leads to chronic low grade inflammation and it’s the acetyl part of aspirin that prevents this.

 

Hans

Member
Thread starter
Joined
Aug 24, 2017
Messages
3,308
Chris Masterjohn thinks salicylate leads to chronic low grade inflammation and it’s the acetyl part of aspirin that prevents this.

All the studies I've seen so far shows that it lower inflammation. How does it increase inflammation according to him?
 

Mito

Member
Joined
Dec 10, 2016
Messages
1,936
All the studies I've seen so far shows that it lower inflammation. How does it increase inflammation according to him?
Since this is one of his “Lite” videos, he didn’t go into all the details. He doesn’t say it increases inflammation, rather it does decrease inflammation but it leads to chronic low grade inflammation because the inflammation is started but not resolved. It’s the acetyl part of Aspirin that allows the COX enzyme to resolve the inflammation rather than completely blocking it. He says most anti-inflammatory drugs completely block the COX enzyme, but aspirin only modifies it. “Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators.”
 

Hans

Member
Thread starter
Joined
Aug 24, 2017
Messages
3,308
Since this is one of his “Lite” videos, he didn’t go into all the details. He doesn’t say it increases inflammation, rather it does decrease inflammation but it leads to chronic low grade inflammation because the inflammation is started but not resolved. It’s the acetyl part of Aspirin that allows the COX enzyme to resolve the inflammation rather than completely blocking it. He says most anti-inflammatory drugs completely block the COX enzyme, but aspirin only modifies it. “Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators.”
Interesting. Here's some research on that.

In contrast, some widely used drugs stimulate resolution and shorten Ri. Distinct from NSAIDs, aspirin decreases Ri by acetylating COX-2, contributing to production of the R-epimer lipoxins, resolvins, and protectins.

We report an aspirin-triggered DHA metabolome that biosynthesizes a potent product in inflammatory exudates and human leukocytes, namely aspirin-triggered Neuroprotectin D1/Protectin D1 [AT-(NPD1/PD1)]. ... These results indicate that AT-(NPD1/PD1) is a potent anti-inflammatory proresolving molecule.

Aspirin acetylation of COX-2 modifies the catalytic domain, blocking PG-biosynthesis, which is well known1,2, yet remains active producing 15R-HETE from arachidonic acid, 18R-HEPE from EPA and 17R-HDHA from DHA in cells carrying COX-2. These can be transformed by human neutrophils in vitro to aspirin-triggered lipoxins, aspirin-triggered resolvins7,8 and aspirin-triggered protectins37. Each potently stops human PMN migration and enhances macrophage cleanup, enhancing resolution in mice.

Thus, the "active site" Ser-530 of PGG/H synthase is not essential for catalysis or substrate binding. Apparently, acetylation of native PGG/H synthase by aspirin introduces a bulky sidechain at position 530 which interferes with arachidonate binding.

It would seem that the lipoxin formation is aspirin specific.
It seems important to note that, in contrast to aspirin, sodium salicylate does not promote the formation of lipoxins.

One up for aspirin!
Still, based on the study above, salicylate has gut benefits. They didn't test aspirin as well, but it would have been interesting to see the effects of aspirin on the gut.
 

Mito

Member
Joined
Dec 10, 2016
Messages
1,936
Still, based on the study above, salicylate has gut benefits.
In the CamphoSal post, Haidut suggests that salicylic acid is quickly metabolized in the stomach and may only reach the very upper portion of the gut. He uses an ester of salicylic acid with phenol in the CamphoSol product because “the esterification allows salicylic acid to survive more or less intact until it reaches the small intestine and colon where it is metabolized by the microbiome and broken down into phenol and salicylic acid.”
 

Hans

Member
Thread starter
Joined
Aug 24, 2017
Messages
3,308
In the CamphoSal post, Haidut suggests that salicylic acid is quickly metabolized in the stomach and may only reach the very upper portion of the gut. He uses an ester of salicylic acid with phenol in the CamphoSol product because “the esterification allows salicylic acid to survive more or less intact until it reaches the small intestine and colon where it is metabolized by the microbiome and broken down into phenol and salicylic acid.”
It is quickly absorbed, but according to the above study, enough salicylate is able to reach the colon to positively modulate the gut bacteria (reset the balance between gram negative and positive bacteria).
 

Broken man

Member
Joined
Sep 11, 2016
Messages
1,470
It is quickly absorbed, but according to the above study, enough salicylate is able to reach the colon to positively modulate the gut bacteria (reset the balance between gram negative and positive bacteria).
So sodium salicylate should prevent the bleeding issue? Thank you.
 

Hans

Member
Thread starter
Joined
Aug 24, 2017
Messages
3,308
So sodium salicylate should prevent the bleeding issue? Thank you.
Not sure if it can prevent the bleeding induced by aspirin and other NSAIDs, but it is gastroprotective against other NSAIDs and other toxins. SA in itself doesn't cause bleeding.
 

Broken man

Member
Joined
Sep 11, 2016
Messages
1,470
Not sure if it can prevent the bleeding induced by aspirin and other NSAIDs, but it is gastroprotective against other NSAIDs and other toxins. SA in itself doesn't cause bleeding.
I am asking because I had bad reaction to classic aspirin by Bayer company, I used the one that is for dissolving into water with vitamin C, so I know that my bad reaction is not caused by other additives because this one is almost pure.
 

Hans

Member
Thread starter
Joined
Aug 24, 2017
Messages
3,308
I am asking because I had bad reaction to classic aspirin by Bayer company, I used the one that is for dissolving into water with vitamin C, so I know that my bad reaction is not caused by other additives because this one is almost pure.
Aspirin is thought to cause bleeding by inhibiting COX in the intestine, whereas SA doesn't. Aspirin is also much more likely to cause bleeding than SA.
 

Broken man

Member
Joined
Sep 11, 2016
Messages
1,470
Aspirin is thought to cause bleeding by inhibiting COX in the intestine, whereas SA doesn't. Aspirin is also much more likely to cause bleeding than SA.
Ohh, I read somewhere that aspirin was made because salicylic acid caused bleeding.. Now I am confused, so salicylic acid is better?
 

Hans

Member
Thread starter
Joined
Aug 24, 2017
Messages
3,308
Ohh, I read somewhere that aspirin was made because salicylic acid caused bleeding.. Now I am confused, so salicylic acid is better?
Salicylic acid and sodium salicylate are two of the least problematic versions. Many studies show that SA doesn't cause bleeding but is actually gastroprotective. Aspirin is rapidly converted to salicylic acid in the body, but it's still aspirin that causes the (micro) bleeding.
 

Dave Clark

Member
Joined
Jun 2, 2017
Messages
1,271
Any recommendations for where, or what company to buy sodium salicylate in powder form. On a search it looks like everything is from lab supply places, and nothing geared to selling as supplement, etc.? Hans, would you say if someone is not having any problem using aspirin powder, that there would be a benefit to converting to sodium salicylate anyway? Thinking that just because you don't feel bad on aspirin, maybe it would still be better to use something that is associated with less side effects (regarding bleeding, etc.).
 

Hans

Member
Thread starter
Joined
Aug 24, 2017
Messages
3,308
Any recommendations for where, or what company to buy sodium salicylate in powder form. On a search it looks like everything is from lab supply places, and nothing geared to selling as supplement, etc.? Hans, would you say if someone is not having any problem using aspirin powder, that there would be a benefit to converting to sodium salicylate anyway? Thinking that just because you don't feel bad on aspirin, maybe it would still be better to use something that is associated with less side effects (regarding bleeding, etc.).
If you're doing great on aspirin, then there is no need to switch. I mainly use it because I can't find pure aspirin here.
 

TheBeard

Member
Joined
May 16, 2018
Messages
2,099
Any recommendations for where, or what company to buy sodium salicylate in powder form. On a search it looks like everything is from lab supply places, and nothing geared to selling as supplement, etc.? Hans, would you say if someone is not having any problem using aspirin powder, that there would be a benefit to converting to sodium salicylate anyway? Thinking that just because you don't feel bad on aspirin, maybe it would still be better to use something that is associated with less side effects (regarding bleeding, etc.).

Bayer's "Aspirine du Rhône" here in France has only two ingredients:
Acetylsalicylic acid
Corn starch
 
Similar threads
Thread starter Title Forum Replies Date
LLight Salicylic Acid Sans Aspirin In Animals And Man Aspirin 0
Lenny Salicylic Acid Safe For Consumption? Aspirin 5
SOMO Oral Dosage For SALICYLIC ACID Same As Oral Dosage For Aspirin? Ask For Help or Advice 0
haidut Neanderthals Used Salicylic Acid And Antibiotics More Than 50,000 Years Ago Scientific Studies 6
haidut Aspirin (salicylic Acid) Inhibits Cortisol Synthesis Scientific Studies 10
P Inhibition of cardiac mitochondrial respiration by salicylic acid and acetylsalicylate. Articles & Scientific Studies 2
cantstoppeating Acetylsalicylic Acid (aka Aspirin) Vs pure Salicylic Acid Aspirin 2
E Salicylate Sensitivity - Adopting A Low Salicylic Diet? Diet 0
M Low or high stomach acid ? How to tell? Digestion 4
M Crazy question, but does putting the finger in the throat to induce gagging , not vommitting, increase stomach acid? Ask For Help or Advice 1
M Influence of carbonic acid on digestion ? Ask For Help or Advice 2
R Beta-alanine actually works for the burn during exercise (lactic acid) Amino Acids 0
M Does taurine increase stomach acid or not? Ask For Help or Advice 3
D Quick lactic acid buildup when climbing stairs Male Issues 27
P Suggestions for low stomach acid, yeast overgrowth? Digestion 20
R Purifying amino acid powder? Amino Acids 0
SatoshiPufamoto Acid Reflux/Possible Hiatal Hernia Ask For Help or Advice 3
Lokzo Increasing Stomach Acid: Hacking Digestion Digestion 2
C Hyaluronic acid Skin 5
D Spinach seed oil, an amazing source of stearic acid and other satured fats Ask For Help or Advice 1
C Anti-Peat Lactic Acid is Antibacterial Debate - Anti-Peat 6
bzmazu Virologists Report Poor Man’s Amino Acid Cure For Covid-19 Would Abolish Need For Vaccines Viruses, Parasites, Fungus, Vaccines 2
R Echinacoside (from cistanche) attenuates kainic acid induced excitotoxicity in rat model Scientific Studies 0
H low stomach acid and low libido issues Digestion 24
R Ascorbic Acid as an antidote to balding? Hair & Nails 4
Lokzo Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice Scientific Studies 0
S Post Workout Lactic Acid Cortisol, Serotonin, Histamine 16
Mauritio Caprylic acid is anti-bacterial, lowers IL-8, helps Glioblastoma Fats 0
Mauritio Caprylic acid effective against Candida albicans , H. Pylori and Cytomegalovirus, more effective than diflucan Science 14
Mauritio Caprylic acid and Thymol very effective against Candida albicans Science 21
mayku-T-meelo Aspirin/Acetylsallicylic acid - source in Europe? Supplements, Pharmaceutical Drugs 9
H Cardiolipin and linoleic acid Metabolism 0
paciencia Low Stomach Acid/Bloating/Silent Reflux Ask For Help or Advice 8
Highserotonin90 Inhibit / slow down excessive Fatty acid oxidation (FAO). Experiments 19
I 2008 Study ; Comparison of lipid and fatty acid profiles of commercially raised pigs with laboratory pigs and wild-ranging warthogs Scientific Studies 0
Lokzo Glycine Reduces NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome - 2020 Supplements, Pharmaceutical Drugs 21
Peroxphos Where to buy bulk succinate / succinic acid in Europe? Supplements, Pharmaceutical Drugs 6
R DSMO with hyaluronic acid Skin 1
K Found A Gem For Starters - Prevention Of Arachidonic Acid‑induced Liver Injury With Garlic Extracts Meet & Greet 5
haidut Melanoma Defined By Increased Fatty Acid Synthesis And Unsaturation Scientific Studies 0
lvysaur Poll: Heartburn (acid Reflux) And Blood Types Digestion, Gut Flora 1
ddjd Thoughts On Folic Acid During Pregnancy? Methylfolate Or Folinic Acid Better? Ask For Help or Advice 7
L September 2020 - Very Interesting Newsletter On Lactic Acid Articles & Newsletters Discussion 45
Amazigh Astronomers Report They’ve Detected The Amino Acid Glycine In The Atmosphere Of Venus Miscellaneous Health Discussions 12
F Is Conjugated Linoleic Acid (CLA) Supplement Safe? Supplements 0
Sexypizza Does Anyone Know Where I Can Buy Camphoric Acid? Digestion 5
jamies33 Is Conjugated Linoleic Acid A PUFA? Milk 0
Amazoniac Using (the Term) 'Lactic Acid' In Physiology Is Dangerous, Should Be Regulated As Drugs Acidity vs. Alkalinity 19
J Ox Bile/Bile Acid Dependency Digestion 2
Hans The Dope On Blocking Fatty Acid Oxidation Articles & Scientific Studies 83

Similar threads

Top