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  1. A

    The glycine deportation system and its pharmacological consequences

    Abstract The glycine deportation system is an essential component of glycine catabolism in man whereby 400 to 800 mg glycine per day are deported into urine as hippuric acid. The molecular escort for this deportation is benzoic acid, which derives from the diet and from gut microbiota metabolism...
  2. Orome

    Aspirin may treat osteoporosis

    This is not the first (human / animal) study coming to this conclusion. But if you do a quick Google search you still get the usual "potential risks outweigh the benefits" results. --- https://pubmed.ncbi.nlm.nih.gov/36050471/ Abstract The use of low-dose aspirin in older adults is increasing...
  3. R

    Aspirin For Gluten Enteropathy

    A nice journal editorial from 1982 about using aspirin to prevent the symptoms of gluten ingestion in coeliac disease. I have celiac and have also found this to be true. https://sci-hub.se/https://pubmed.ncbi.nlm.nih.gov/6127560/
  4. haidut

    Aspirin may treat pancreatitis...and other fibrotic conditions

    While most of medicine's attention is focused on acute pancreatitis (AP) since AP is often deadly, rates of chronic pancreatitis (CP) have been rising over the last 2-3 decades and it is now recognized that CP is a "gateway" condition to either liver or pancreatic cancers. Officially, CP has no...
  5. UG Krishnamurti

    The reason why aspirin causes intestinal discomfort, intestinal bleeding, tinnitus or kidney pain in some people?

    According to this study they've made a bold claim that all IBD (Inflammatory bowel diseases) are caused by Mycobacterium avium subspecies paratuberculosis (MAP) "we additionally suggest that all of IBD may be caused by MAP [16, 22, 26]" They also shown that all "antiinflammatories" and...
  6. C

    Why does Aspirin give me painful hot toes & finger joints?

    a lot of ppl use aspirin here & i do notice mood enhancing effects the times I try it. But even lower doses gives me painful stiff very hot fingers and toes reliably & acutely. I get this at other times too mostly at nighttime for some unknown reason - but i noticed Aspirin is a definite acute...
  7. BestSinceDAYONE

    Best Ways to Fight EMF / Ionizing Radiation

    Let me preface this before anything, that I never used to believe in this type of effect causing major damage to people...but let's just say I have felt the exact effects and I notice EXACTLY when I am getting hit with something, major migraine, fatigue, burning sensations etc. My question is...
  8. Mauritio

    Carbonic anhydrase II as a biomarker for vascular calcification

    "Several other synthetic estrogenic substances, ethynylestradiol, lindane, PCBs, cause eggshell thinning, partly by altering carbonic anhydrase activity (Holm, et al, 2006). Estrogen and serotonin activate carbonic anhydrase in some tissues, progesterone tends to inhibit it." -Ray Peat Peat has...
  9. Jonathan Estis

    For 325 mg aspirin tablets... which brand is better?

    planning on doing 2g+ aspirin per day with high caffeine as alternative to DNP for weight loss. I want to know which brand of aspirin sits right with most people. i've only used healthA2Z brand in the past for lower doses and it has worked without problems while using kuinone k2 to mitigate...
  10. haidut

    Low-dose aspirin may prevent most dementias (even Alzheimer's)

    Over the last couple of months, a few studies came out arguing (again) that aspirin is not worth the risk and that people should stop taking it. It seems that Big Pharma has a schedule of pumping propaganda out every year or so against the main "threats" to its dominance - aspirin, vitamin D...
  11. NewACC

    Aspirin Cause Antiserotonine Effect Only At Low Doses (My Vision of the Non-Linear Dose-Dependent Antiserotonin Effect of Aspirin)

    Dear peats! As you all know, serotonin has a direct aggregative coagulant effect through the 5-ht2 family of receptors. And so, aspirin has the strongest antiplatelet effect at doses below 325 mg. We also know that aspirin has the most potent beneficial effect on tyrosine hydroxylase at a...
  12. NewACC

    My Vision of the Non-Linear Dose-Dependent Antiserotonin Effect of Aspirin

    Dear peats! As you all know, serotonin has a direct aggregative coagulant effect through the 5-ht2 family of receptors. And so, aspirin has the strongest antiplatelet effect at doses below 325 mg. We also know that aspirin has the most potent beneficial effect on tyrosine hydroxylase at a...
  13. H

    Aspirin use

    There was an article published in the ESC Heart Failure in November 2021 putting some negative light on aspirin use, just in case somebody did not see it. Maybe worthwhile to discuss. https://onlinelibrary.wiley.com/doi/epdf/10.1002/ehf2.13688
  14. 3

    HealthPartners gives thumbs up to aspirin for more people

    https://www.startribune.com/aspirin-guidance-influenced-by-minnesota-research/600168053/ “The task force urges people 40-59 with 10% risk of heart disease in a decade to talk with their doctors about aspirin, whereas it previously recommended the pills for people in their 50s but offered no...
  15. A

    Aspirin could act as a suicide inhibitor of carbonic anhydrase II

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226357/ Abstract Carbonic anhydrase II (CAII) is a metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3−. In addition, CAII is attributed to other catalytic reactions, including esterase activity. Aspirin (acetyl-salicylic...
  16. haidut

    Aspirin can slow down the progression of emphysema

    Yet another study, adding to the mountain of evidence that if there is such a thing as a "wonder drug" then aspirin comes as close to it as possible. The study findings are great news not only because emphysema is such a widespread disease, but also because it is considered both progressive and...
  17. A

    Calcium can delay age-related macular degeneration via enhanced copper metabolism

    ABSTRACT Secondary analyses of data from the Age-Related Eye Disease Study (AREDS) revealed that higher calcium intakes were associated with slower progression to age-related macular degeneration (AMD). Earlier, primary analyses had revealed that a supplement containing copper reduced the odds...
  18. TheCedar1

    I took 2 grams of aspirin a week before and even after the vaccine (it became mandatory in LB), should i be worried about the side effects?

    Basically as the title said, I took 2 grams aspirin a week before the vaccine (Moderna) and continued after as well, all I had was a severe headache day after vaccination, which I took 2 grams again of aspirin and it went away within 15 minutes Should I worry about the vaccine? If yes, what do...
  19. M

    Aspirin to double weight loss.

    I have been taking 5 aspirins in the morning and 2 aspirins every 2 hours with vitamin C 1 gram for 5 days so far. I went from 228 to 223. Lost a pound a day. I'm on a 500-1000 calorie deficit to accomplish this. It's like dnp but with less side effects and it's lighter then caffeine is on...
  20. Brandin

    Peaty bodytransformation

    This is what around 3.5 years of religious peating and working out did to my body. I know some people wont be interested in this but I have seen people on here being interested in bodybuilding, looks and just androgen hormone optimization so im posting it for that respective audience...