PROGESTERONE recommendations by Dr. Ray Peat

Birdie

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For topical treatment of sun damaged skin, or acne, wrinkles, dark marks, the oil can be applied directly to the affected areas.

Since progesterone has none of the harmful side effects of other hormones (except the alteration of the menstrual cycle if taken at the wrong time of the month), the basic procedure should be to use it in sufficient quantity to make the symptoms disappear, and to time its use so that menstrual cycles are not disrupted. This normally means using it only between ovulation and menstruation unless symptoms are sufficiently serious that a missed period is not important to you.

If a person has an enlarged thyroid gland, progesterone encourages secretion and unloading of the stored colloid and can bring on a temporary hyperthyroid state which is a corrective process. A thyroid supplement (Electrical Body recommends Detoxadine) may be used to shrink the goiter before progesterone is given.

Normal amounts of progesterone promote thyroid secretion, while a deficiency, especially when too much estrogen is present, causes the thyroid to enlarge. Some mention euphoria as a "side-effect" of progesterone usage, but euphoria is simply an indication of good physiological state. To avoid unexpected anesthesia, the correct dose should be determined by taking about 10 mg (3-4 drops) at a time, allowing it to spread into the membranes of the mouth, and repeating the dose after 10 minutes until the symptoms are controlled.

An excessive estrogen/progesterone ratio (should be 1 part to 10 parts, estrogen to progesterone), is involved in producing aggravating symptoms such thin, bluish skin. Low thyroid is one cause of excess estrogen, and when high estrogen is combined with low thyroid function, the skin can look relatively bloodless.

Symptoms in cycling women are most common around ovulation and in the premenstrual week, when the estrogen/progesterone ratio is normally highest. At puberty, in the early twenties and in the late thirties and menopause are the ages when the ratio is most often disturbed - and these are also the ages when thyroid disorders are most common.
The individual who suffers from one aspect of progesterone (and/or thyroid) deficiency will tend to develop other problems at varying times.

With cyclic depression or migraine headaches at 22, there will possibly be breast disease after, and often there will be problems with pregnancy. These people with a history of severe symptoms are the ones most likely to have problems around menopause. Prenatal exposure to poorly balanced hormones seems to predispose children to later hormone imbalances.

Excess stress (which can block progesterone synthesis and elevate estrogen) may being on symptoms in someone who never had them. As well as darker days without sun, toxins and nutritional deficiencies. A very common cause of an estrogen excess is a dietary protein deficiency because the liver cannot detoxify estrogen when it is under nourished.

With a diet high in protein and vitamin A, progesterone can usually be reduced each month. Using thyroid supplementation will also usually reduce the amount of progesterone needed. Occasionally, a women won't feel any effect even from 100 mg of progesterone and this may indicate they need to use thyroid supplementation and diet changes to normalize their estrogen, prolactin and cortisol levels.

Progesterone stimulates the ovaries and adrenals to produce progesterone, and it also activates the thyroid. It shouldn't be necessary to use progesterone indefinitely unless the ovaries have been removed. In slender post-menopausal women, 10 mg per day is usually enough to prevent progesterone deficiency.

In a 10% solution of progesterone in vitamin E, one drop contains about three milligrams of progesterone. Normally the body produces 10 to 20 milligrams per day. A dose of 3 or 4 drops usually brings the blood levels up to normal range, but this dose can be repeated throughout the day to control symptoms.

For general purposes, it is most economical and effective to take progesterone dissolved in vitamin E orally, for example taking a few drops on the lips and tongue, or rubbing it into the gums. (It is good for the general health of the gums, too.) These membranes are very thin and hence the progesterone can easily and quickly enter the blood. when swallowed, the vitamin E allows it to be absorbed through the walls of the stomach and intestine.

As was mentioned previously, topical application of this oil aids sun damaged skin. For topical treatment of arthritis, osteoporosis, tendinitis, bursitis, or varicose veins, to speed absorption it is best to apply a few drops of olive oil to the area, and then to rub the progesterone -vitamin E solution into and around the affected area.

Around menopause, a 14 day use pattern, followed by 14 days of no use, seems reasonable unless symptoms such as hot flashes, recur when the oil is stopped. In that case, the person could try continuous use for a month or two, then a return to cycling.

It does not need to be rotated on the skin, although some people prefer to do it that way.

Recommendations posted at electrical body. Paragraph divisions added by me for easier reading.​
 

Peatress

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Thank you. I'm adding this quote from my notes. I don't have the original source but I suspect it might be from a transcript posted on the forum

Ray Peat on the Effects of Progesterone on Estrogen

Caller
: My question is about Dr. Peat’s newsletter on “Tissue-bound estrogen and aging”: he mentions that menopausal women often get high estrogen concentration in their tissue, as opposed to their blood. Could they get a dose of progesterone to knock it out of their tissue into their blood, and then get a phlebotomy? Would that help to decrease systemic estrogen ?

RP: No. If the liver is working, and if you’re eating enough protein, and if your thyroid is ok, your liver will send the estrogen straight to your kidneys, to be excreted, as soon as the progesterone gets it out of your cells into the bloodstream.
And there are several enzyme systems involved in this: the progesterone basically destroys the estrogen receptor that binds estrogen. It destroys the enzyme that releases estrogen from the glucuronic form deposited in cells. It activates the enzymes that add the glucuronic acid to remove it from cells. And it shifts the oxidative enzymes, so that they destroy the active form of estrogen. So, everything progesterone does to estrogen system, gets it out of the cells, then your liver will send it to your kidneys to excrete.

HD: And progesterone helps the liver to get rid of excess estrogen as well.

RP: Yeah. Progesterone activates the thyroid to do that.
 
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Birdie

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Wonderful Peatress.
 
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