Optimal Dose Of Pregnenolone For Androgen Synthesis

[gilson dantas]

I was just thinking the same thing!

Thank you @Blossom!! Very interesting!!

 

[Kray]

Ok so what do u think about 300mg/week i single doses? I ask because that'e what I'm taking.

@goodandevil: How did you arrive at dose of 300mg x 1/week (per Peat's anecdotal findings)? It's rather confusing, to say the least, after reading this thread, whether best to dose throughout the day, once per week, or cyclic, say 3 weeks on and 1 week off to guard against negative feedback loop.

Then-- how much? And I do believe the dosage levels may not be optimally the same between needs of male and female. I'm female, and I'm taking 100mg/day, in one capsule, and feel pretty good, sleeping better, overall better mood and energy.

Peat has said pregnenolone recyles through the intestine throughout the week following a single dose. What then, does continued daily use mean? How much really gets used out of a 100mg capsule? I don't know if it would be similar to oral progesterone, but I believe that 100mg oral progesterone only yields about 20mg after liver processing, etc.

 

[gilson dantas]

Good questions @classicallady!

 

[Kray]

That dose it probably not going to raise progesterone to the point of causing anti-androgenic effects. The physiological doses of pregnenolone are about 30mg - 50mg daily, so that's pretty much what you are taking with that single weekly dose.

@haidut: I'm a little confused on your comment-- if a single 300mg dose wouldn't cause anti-androgenic effects, then why do you suggest the need to split a 50mg dose throughout the day?

 

[gilson dantas]

Good question @haidut!

 

[haidut]

@haidut: I'm a little confused on your comment-- if a single 300mg dose wouldn't cause anti-androgenic effects, then why do you suggest the need to split a 50mg dose throughout the day?

Where did you see me recommending splitting 50mg dose? I said a daily dose of 30mg - 50mg was found effective in a few human studies while the higher doses was not. The difference with the 300mg dose is that it is taken only once weekly, so by the second day it has already metabolized into downstream hormones. Taking it on a daily basis though (or even 100mg on a daily basis) will start to manifest the progesterone effect. See this.
Optimal Dose Of Pregnenolone For Androgen Synthesis

 

[Kray]

Where did you see me recommending splitting 50mg dose? I said a daily dose of 30mg - 50mg was found effective in a few human studies while the higher doses was not. The difference with the 300mg dose is that it is taken only once weekly, so by the second day it has already metabolized into downstream hormones. Taking it on a daily basis though (or even 100mg on a daily basis) will start to manifest the progesterone effect. See this.
Optimal Dose Of Pregnenolone For Androgen Synthesis

It's how I read your posts to @Wagner83, post #14, and to @milk_lover, post #15.

 

[haidut]

It's how I read your posts to @Wagner83, post #14, and to @milk_lover, post #15.

Oh, my point in these is that the smaller the specific dose of pregnenolone the higher the chance that it will convert down both pathways (progesterone and DHEA) than just progesterone. Some people will probably do fine on 30mg - 50mg single dose. Others will need the splitting to get more of an androgenic effects. If you are also taking DHEA then I would split whatever total daily dose of pregnenolone you plan on taking into as many doses as the DHEA. So, if you are taking 5mg DHEA x 3 daily and also plan on taking 30mg pregnenolone daily, I would split that pregnenolone dose so that each steroid dose is 10mg pregnenolone + 5mg DHEA, taken three times daily.
Pregnenolone seems to be quite powerful. An older study from the 1950s found that even 1mg dose before bed improved sleep quality drastically.

 

[goodandevil]

@goodandevil: How did you arrive at dose of 300mg x 1/week (per Peat's anecdotal findings)? It's rather confusing, to say the least, after reading this thread, whether best to dose throughout the day, once per week, or cyclic, say 3 weeks on and 1 week off to guard against negative feedback loop.

Then-- how much? And I do believe the dosage levels may not be optimally the same between needs of male and female. I'm female, and I'm taking 100mg/day, in one capsule, and feel pretty good, sleeping better, overall better mood and energy.

Peat has said pregnenolone recyles through the intestine throughout the week following a single dose. What then, does continued daily use mean? How much really gets used out of a 100mg capsule? I don't know if it would be similar to oral progesterone, but I believe that 100mg oral progesterone only yields about 20mg after liver processing, etc.

Hey classical lady,

Well ray said he tested it from the semtex factory in 80s and used massive quantities, 5 grams a day, i think, for a year, and had zero side effects. Zero with a capital Z is what he told me. While it's possible that pregnenolone encourages a different hormonal profile at high vs low doses, for men i dont believe that corresponds to decreased androgenic charscteristics, and for women, the kncreased progesterone is nothing to worry about and can only je said to be good. my primary concern would be obtaining clean pr3gnenolone. anyways i have faith in what ray says i think the more, the better. He's a careful man and i believe he tested it quite extensively. anyways, yeah, that's the dose ray recommended.

 

[Kray]

Hey classical lady,

Well ray said he tested it from the semtex factory in 80s and used massive quantities, 5 grams a day, i think, for a year, and had zero side effects. Zero with a capital Z is what he told me. While it's possible that pregnenolone encourages a different hormonal profile at high vs low doses, for men i dont believe that corresponds to decreased androgenic charscteristics, and for women, the kncreased progesterone is nothing to worry about and can only je said to be good. my primary concern would be obtaining clean pr3gnenolone. anyways i have faith in what ray says i think the more, the better. He's a careful man and i believe he tested it quite extensively. anyways, yeah, that's the dose ray recommended.

I agree with you-- Peat is quite cautious. I assume you are still cycling the one dose weekly @300mg? For how long, and how are you feeling balance-wise? I'm interested in having my husband do the once-weekly dose @300mg for sake of ease as he's not a pill guy. He's pushing age 60-- from what you've read would older people require a greater dosage than, say, someone in their 30s to 40s?

Do you complement with any DHEA? I know Peat has done a real turn-around with recommending DHEA given studies showing negative effects over time. I would hope that pregnenolone would be sufficient to cover the bases for the downstream hormones, eliminating the need to supplement them individually.

Thank you for getting back to me on this-

 

[goodandevil]

I agree with you-- Peat is quite cautious. I assume you are still cycling the one dose weekly @300mg? For how long, and how are you feeling balance-wise? I'm interested in having my husband do the once-weekly dose @300mg for sake of ease as he's not a pill guy. He's pushing age 60-- from what you've read would older people require a greater dosage than, say, someone in their 30s to 40s?

Do you complement with any DHEA? I know Peat has done a real turn-around with recommending DHEA given studies showing negative effects over time. I would hope that pregnenolone would be sufficient to cover the bases for the downstream hormones, eliminating the need to supplement them individually.

Thank you for getting back to me on this-

Oh yeah i still take 300 once weekly. might do more but it's expensive maybe we neee to make a buyer's club on here to get the high-quality pregnenolone more cheaply. anyways ray says to take the dhea with fat i mix 5mg at a time with coconut oil. if dhea feels good, it is good. i feel great at 300mg. i feel experimentatio is vital and i would encourage your husband to experiment with higher doses so long as the pregnenolone is clean. i trust ray.

 

[Wagner83]

I think what a man wants to achieve as his personal state of health (body, mind, emotions) , what he perceives as doing great may not be the same for all . For example sexuality could be perceived differently in Peat's eyes from the eyes of a young lad raised watching porn and partying, physical health could be perceived differently between Peat and a bodybuilder.

 

[Kray]

I think what a man wants to achieve as his personal state of health (body, mind, emotions) , what he perceives as doing great may not be the same for all . For example sexuality could be perceived differently in Peat's eyes from the eyes of a young lad raised watching porn and partying, physical health could be perceived differently between Peat and a bodybuilder.

Ha! What an understatement.

 

[Kray]

Does someone know how 100mg pregnenolone would

Oh yeah i still take 300 once weekly. might do more but it's expensive maybe we neee to make a buyer's club on here to get the high-quality pregnenolone more cheaply. anyways ray says to take the dhea with fat i mix 5mg at a time with coconut oil. if dhea feels good, it is good. i feel great at 300mg. i feel experimentatio is vital and i would encourage your husband to experiment with higher doses so long as the pregnenolone is clean. i trust ray.

Are you taking a bulk powder, or capsules/tablets? It's hard to find a ready-made supplement without some kind of filler, although there is one I've bought before, it just doesn't come in higher doses, so it's a little pricey for higher dosing. Good point on purity. Maybe if that issue is eliminated, a lower dose potentially would yield better results than a higher dose with fillers or irritants (didn't someone suggest this earlier?).

I always like to go back and read this article as a reference point: http://raypeat.com/articles/articles/three-hormones.shtml

Thanks again for your input and suggestions!

 

[Kray]

I'm throwing in a related question: If you're taking it orally, is there a benefit in using micronized over non-micronized pregnenolone? I couldn't seem to find anything on the forum addressing this issue. If anyone has information on this, I would appreciate knowing.

 

[goodandevil]

Does someone know how 100mg pregnenolone would


Are you taking a bulk powder, or capsules/tablets? It's hard to find a ready-made supplement without some kind of filler, although there is one I've bought before, it just doesn't come in higher doses, so it's a little pricey for higher dosing. Good point on purity. Maybe if that issue is eliminated, a lower dose potentially would yield better results than a higher dose with fillers or irritants (didn't someone suggest this earlier?).

I always like to go back and read this article as a reference point: http://raypeat.com/articles/articles/three-hormones.shtml

Thanks again for your input and suggestions!

Hey i use healthnatura for pregnenolone. they're overpriced and somewhat disrepuable, take forever to ship, bjt their pregnenolone is clean. for dhea i use bulk supplements on amazon. i think ray said the micronized is just a gimmick. i think there's another ean source of pregnenolone, it might be on dan's toxinless.org website.

 

[Agent207]

Hey i use healthnatura for pregnenolone. they're overpriced and somewhat disrepuable, take forever to ship, bjt their pregnenolone is clean. for dhea i use bulk supplements on amazon. i think ray said the micronized is just a gimmick. i think there's another ean source of pregnenolone, it might be on dan's toxinless.org website.

Overpriced? I see its products generally good priced, clean and very high quality. 5gr pregnenolone should last a year.

 

[Kray]

Hey i use healthnatura for pregnenolone. they're overpriced and somewhat disrepuable, take forever to ship, bjt their pregnenolone is clean. for dhea i use bulk supplements on amazon. i think ray said the micronized is just a gimmick. i think there's another ean source of pregnenolone, it might be on dan's toxinless.org website.

What I thought as well, a gimmick. On the DHEA, you mention 5mg portions, do you also take 1 weekly dose of DHEA with your pregnenolone?

 

[Kray]

Hey i use healthnatura for pregnenolone. they're overpriced and somewhat disrepuable, take forever to ship, bjt their pregnenolone is clean. for dhea i use bulk supplements on amazon. i think ray said the micronized is just a gimmick. i think there's another ean source of pregnenolone, it might be on dan's toxinless.org website.

fwiw: Have you read this article on Peat's thoughts regarding DHEA? Looks like the article was last updated 2006, so I'm not sure if his position on DHEA has changed since:

Pregnenolone - A Fruit Of Cholesterol (see WARNING ON DHEA)

 

[goodandevil]

Overpriced? I see its products generally good priced, clean and very high quality. 5gr pregnenolone should last a year.

They're well priced for a monopoly. he has good pregnenolone, im thankful for thayt, but his products are expensive and his shipping is very slow. Like many marketers, he makes an advertisement out of these deficiencies. 5grMs at 300 mgs/week would be four months and that's a low dose of pregnenolone. maybe @Dan Wich can find a cheaper, clean version. i've heard another brand name being bandied about.