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Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative... - Europe PMC Article - Europe PMC
Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia
Take a look at table 6. Mostly increased allopregnanolone, pregnenolone sulfate, progesterone and estrogen*
* Strangely, although table shows a dramatic and surreal increase in estradiol, statements below says the opposite, maybe a typo?
"
Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia
Take a look at table 6. Mostly increased allopregnanolone, pregnenolone sulfate, progesterone and estrogen*
* Strangely, although table shows a dramatic and surreal increase in estradiol, statements below says the opposite, maybe a typo?
"
Absence of conversion to other steroids
Pregnenolone administration for 8 weeks to patients with schizophrenia or schizoaffective disorder did not result in downstream elevations of cortisol, testosterone, free testosterone, DHEA, androstenedione, or estradiol (Table 6). As pregnenolone is a potential precursor to a number of steroids, pregnenolone could theoretically be metabolized to all of these molecules. Our data suggest, however, that pregnenolone metabolism is weighted toward biosynthetic pathways resulting in pregnenolone sulfate and allopregnanolone formation, rather than toward glucocorticoid or sex steroid synthesis involving testosterone or estradiol.
"Pregnenolone administration for 8 weeks to patients with schizophrenia or schizoaffective disorder did not result in downstream elevations of cortisol, testosterone, free testosterone, DHEA, androstenedione, or estradiol (Table 6). As pregnenolone is a potential precursor to a number of steroids, pregnenolone could theoretically be metabolized to all of these molecules. Our data suggest, however, that pregnenolone metabolism is weighted toward biosynthetic pathways resulting in pregnenolone sulfate and allopregnanolone formation, rather than toward glucocorticoid or sex steroid synthesis involving testosterone or estradiol.
