androgen

  1. haidut

    Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens

    A very interesting study that highlights yet again the connection between chronic stress and ill systemic health, especially cardiovascular disease (CVD). The study demonstrates that people who had experienced a heart attack have dramatically higher higher cortisol and adrenaline/noradrenaline...
  2. fever257

    HCG And Proviron - Are They Safe?

    Hello, I need to inquire about the safety of two separate drugs/steroids that I'm inclined to take. Both of these would be to optimize hormonal issues engendered by 5-AR blocking via finasteride. I'm positive that I need to push my system artificially with a drug in order to heal my hormones...
  3. haidut

    Androgens Boost, Estrogen Inhibits, Anti-aging Gene Klotho

    This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR)...
  4. haidut

    Irritable Bowel Syndrome (IBS) Caused By Histamine And Serotonin

    I did not expect to see this statement in a mainstream science news outlet, but here it is below. I am starting to see a change in attitude towards serotonin but mainstream medicine is careful about its game. Somehow, the message about serotonin has now split into two separate, nonsensical ones...
  5. haidut

    Aromatase Inhibitor (AI) + DHT Combo May Reverse Kidney Disease (CKD)

    A truly great study for a number of reasons. First, it cites extensive evidence that male patients with diabetes (both types) have low androgens and high estrogen (estradiol). The association between this endocrine abnormality and the severity of diabetes is apparently quite strong, yet it is...
  6. haidut

    Topical DHEA Has Potent Anti-aging Effects On Human Skin

    I often get emails in regards to possible interventions with anti-aging effects on skin. The study I usually quote is an old one (circa 1967) that did extensive tests on 200+ people with age range of 57-88 years residing in a retirement home, and demonstrated that topical testosterone (1%) cream...
  7. ScurveDream

    Long Chins, Big Ears, Long/narrow Faces = GH, Estrogen?

    I notice some feature mix ups and combinations. Guys with stronger jaws (not sure about women though) tend to have larger ears, but there are guys with big ears and longer chins (downward protruding more than forward) that lack the same jaw types and facial broadness. Since the effects of GH...
  8. haidut

    DHT Is Negatively Associated With Death From Prostate Cancer

    Just a quick study that, despite being epidemiological, raises serious questions about the validity of the "androgen-driven" hypothesis of prostate cancer. If the assumption is that DHT is the primary driver of prostate cancer it is hard to come up with any plausible explanation of how the...
  9. haidut

    Estrogen, Not Androgens, May Be The Cause Of Baldness

    A quick post about a study calling into question yet another dogma in medicine - i.e. that the "evil" androgens (especially DHT) are the causes of men losing their hair and getting prostate cancer. So, the "solution" modern medicine proposes is "chemical castration" with drugs like finasteride...
  10. haidut

    Estrogen And Cortisol, Not Androgens, Suppress Immunity

    There is a very famous theory in reproductive biology still considered the dominant one in its field. Namely, males have to accept a trade-off between androgen levels and immunity. It is known as the immunocompetence handicap hypothesis (ICHH). Higher androgen levels, the theory goes, allow the...
  11. haidut

    Drop In Androgen Levels Causes Parkinson Disease (PD), DHT Reverses It

    Yet another study demonstrating that many of the so-called chronic, degenerative and above all "mysterious" conditions often have quite a simple cause and, potentially, treatment. There is no need for mutated genes or complex interactions of genes with environment that nobody can decipher...
  12. haidut

    Testosterone Does NOT Impair Empathy In Men

    I am sure most readers are quite familiar with the cliche that testosterone (T) is what drives stereotypical "boy behavior" - aggressiveness, carelessness, impulsive behavior, risk taking, cheating, and of course the militaristic attitude characterized by lack of (or reduced) empathy. As I...
  13. haidut

    Drostanolone (a DHT Isomer) May Treat Prostate Cancer

    The bad news for the DHT-driven theory of prostate cancer just keep piling on. There have been at least 3 human trials in the last 5 years demonstrating that the direct injection of testosterone (T) into the prostate can stop advanced, inoperable prostate cancer. There are also studied showing...
  14. haidut

    Androsterone May Be The Main Source Of DHT, Drives Fetal Masculinization

    The study below demonstrates that not only may androsterone be the primary pro-hormone used endogenously for DHT synthesis, it likely also drives the masculinization of sexual organs in the fetus. For a long time it was thought that the so-called "front pathway" using testosterone (T) produced...
  15. GutFeeling

    Relative Testosterone Deficiency And Hypogonadotropism May Lead To Zinc Deficiency

    Zinc deficiency tends to cause few androgens but according to this study it is possible that androgen deficiency causes zinc deficiency. Zinc increases when methyltestosterone is given, especially in boys with growth delay. And zinc level in boys beyond stage 3 of genital development are higher...
  16. haidut

    Low DHEA-S Predicts Fractures In Older Men

    There is a big push to start treating older men with estrogen, just as women are, because estrogen is "good for the bone". No evidence exists to support this approach and in fact multiple studies in women have shown that low DHEA, and not estrogen, is what is associated with weak bones. In...
  17. haidut

    PUFA Is Estrogenic And Androgen/Progesterone Antagonist

    As Peat mentioned many times and I discussed on Danny Roddy's shows, PUFA is a powerful endocrine disruptor. As such, it has direct effects on steroids and expression of steroids receptors in cells that go beyond its metabolism into the inflammatory mediators (even though those amplify the...
  18. haidut

    Omega-3 (DHA, EPA) Degrades The Androgen Receptor

    One of the reasons the medical industry continues to promotes the use of fish oils is that in animal studies it was shown to shrink the prostate. The mechanism was never fully elucidated, but I suspected it is probably not a good one. This study shows that omega-3 fatty acids are anti-androgenic...
  19. haidut

    Strong Androgens (DHT) As Treatment For CVD, Obesity And Metabolic Syndrome

    The study used DHT as the active drug but since the positive effects were due to androgen receptor agonism, any other strong androgen agonist should do. I think the lack of estrogenicity also contributed to the benefits of DHT observed in this study, so this would explain the mixed results with...
  20. haidut

    The Antidepressant Mechanism Of Androsterone

    There is solid evidence that androgens have potent antidepressant effects in both sexes. However, the mechanism of action of that antidepressant effect has not been fully elucidated yet. On the other hand, it is also well known that chemicals that increase the levels of the so-called...
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