androgen

  1. haidut

    Stress ups cortisol/estrogen/prolactin, drops DHT, causes male infertility and prostate issues

    If you try to discuss infertility with a fertility/reproductive specialist or an endocrinologist, and mention that chronic stress may be a factor in infertility, you will probably get laughed out of the room. This is not just speculation. This exact same thing happened to several friends and...
  2. haidut

    DHT, not T, likely the "active" androgen in heart and brain

    Interesting study, done on baboons (so should have good relevance for humans), demonstrating that the cardiovascular system (CVS) exclusively accumulates and recognizes (at the receptor level) DHT, instead of testosterone (T). In fact, the androgen receptor in CVS is so structurally different it...
  3. haidut

    Estrogens cause obesity / PCOS in women, DHT is protective

    Female obesity and the closely related condition PCOS are perhaps the female equivalent of the so-called "androgen hypothesis" for balding and prostate cancer in men, as the female version of this hypothesis not only blames androgens for these conditions but specifically singles out DHT as the...
  4. haidut

    Low DHT can cause hypogonadism symptoms even in eugonadal men

    Seemingly contradictory title, but the study findings are pretty clear. Namely, even in males with normal testosterone levels there is a direct inverse relationship between DHT levels and symptoms of hypogonadism such as sexual dysfunction and "aging male" syndrome. For every 10% increase in DHT...
  5. haidut

    Androgens (T, DHT) highly protective against the flu

    A gem of a study that throws a wrench in one of medicine's core dogmas - i.e. androgens have detrimental effects on the immune system and males have evolved to live with a trade-off between high androgen levels (and as such high fertility) and higher risk of severe viral episodes that can be...
  6. cupofcoffee

    Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men

    https://link.springer.com/article/10.1007/s40618-021-01561-0
  7. Mauritio

    The skin as a steroidogenic organ

    Here's a collection of studies on the skin as a steroidogenic organ mainly to show that hormones like pregnenolone have a different metabolization topically, compared to orally. "The cutaneous steroidogenic system can also have systemic effects, which are emphasized by significant skin...
  8. cupofcoffee

    Trenbolone Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic S

    https://academic.oup.com/endo/article/157/1/368/2251856 perhaps this shows how non-aromatizable steroids can be more beneficial than testosterone in certain subjects. What do you think @haidut? is trenbolone peaty? /s
  9. haidut

    Topical DHT therapy promotes hair growth

    Despite mentioning it in another post on testosterone (T) treatment for hair loss, I thought that this study deserves its own post, just because its findings are so contradictory to the perennial dogma of "androgenic alopecia" - i.e. that androgens, and especially DHT, cause the male-pattern...
  10. haidut

    Testosterone therapy (TRT) reverses hair loss (in women)

    The evidence undermining the fake/corrupt hypothesis of "androgenic alopecia" keeps accumulating. I really wish the study below was conducted in men instead of women, since its findings would have probably finally put an end to the debate as to whether androgens promote or inhibit hair growth...
  11. haidut

    DHT restores anabolism / vitality / sexuality even in 90+ y.o. males

    A great study, a true blast from the (better) past, when androgenic steroids and especially DHT were not considered the devil reincarnate, but were commonly used for all types of ailments, including the broad physiological and psychological symptoms of aging such as sarcopenia (muscle loss)...
  12. haidut

    Androgens (e.g. DHT) curative even for treatment-resistant breast cancer

    As many of my readers know, back in the "good ol' days" (when medicine was slightly less evil and berserk) breast cancer in women was treated with androgens, and the results were so impressive that a synthetic DHT-derivative known as Drostanolone / Masteron (2α-Methyl-DHT) was approved by the...
  13. haidut

    Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens

    A very interesting study that highlights yet again the connection between chronic stress and ill systemic health, especially cardiovascular disease (CVD). The study demonstrates that people who had experienced a heart attack have dramatically higher higher cortisol and adrenaline/noradrenaline...
  14. fever257

    HCG And Proviron - Are They Safe?

    Hello, I need to inquire about the safety of two separate drugs/steroids that I'm inclined to take. Both of these would be to optimize hormonal issues engendered by 5-AR blocking via finasteride. I'm positive that I need to push my system artificially with a drug in order to heal my hormones...
  15. haidut

    Androgens Boost, Estrogen Inhibits, Anti-aging Gene Klotho

    This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR)...
  16. haidut

    Irritable Bowel Syndrome (IBS) Caused By Histamine And Serotonin

    I did not expect to see this statement in a mainstream science news outlet, but here it is below. I am starting to see a change in attitude towards serotonin but mainstream medicine is careful about its game. Somehow, the message about serotonin has now split into two separate, nonsensical ones...
  17. haidut

    Aromatase Inhibitor (AI) + DHT Combo May Reverse Kidney Disease (CKD)

    A truly great study for a number of reasons. First, it cites extensive evidence that male patients with diabetes (both types) have low androgens and high estrogen (estradiol). The association between this endocrine abnormality and the severity of diabetes is apparently quite strong, yet it is...
  18. haidut

    Topical DHEA Has Potent Anti-aging Effects On Human Skin

    I often get emails in regards to possible interventions with anti-aging effects on skin. The study I usually quote is an old one (circa 1967) that did extensive tests on 200+ people with age range of 57-88 years residing in a retirement home, and demonstrated that topical testosterone (1%) cream...
  19. ScurveDream

    Long Chins, Big Ears, Long/narrow Faces = GH, Estrogen?

    I notice some feature mix ups and combinations. Guys with stronger jaws (not sure about women though) tend to have larger ears, but there are guys with big ears and longer chins (downward protruding more than forward) that lack the same jaw types and facial broadness. Since the effects of GH...
  20. haidut

    DHT Is Negatively Associated With Death From Prostate Cancer

    Just a quick study that, despite being epidemiological, raises serious questions about the validity of the "androgen-driven" hypothesis of prostate cancer. If the assumption is that DHT is the primary driver of prostate cancer it is hard to come up with any plausible explanation of how the...
Top