1. haidut

    PUFA peroxidation can cause heart failure, latter can be reversed

    The mainstream view on heart failure is that in most cases (when it is not congenital) it is a secondary morbidity caused by conditions such as diabetes, CVD, obesity, smoking, alcohol intake, etc. However, a direct causative agent and process has not been proposed so far. The study below...
  2. Mauritio

    Cyanidin-3-O-glucoside (C3G), the next polyphenolic StAR ?

    Through reading about polyphenols I discovered this interesting compound that possibly has some interesting effects. It seems to boost Progesterone,Pregnenolone and Testosterone and various steroidogenic enzymes, especially the rate limiting enzyme StAR (hence the title). It also increases the...
  3. L


    Through research and experience, I’ve come to the conclusion that aromatase inhibition is crucial for having high testosterone. Many who take DHEA, DHT, T. etc. and don’t experience the expected conditions of having high T, may benefit from the inhibition of aromatase. Well cooked button...
  4. haidut

    Androgens, glucocorticoids are antagonistic - former inhibit, latter promote fat gain

    As most of my readers know, androgenic steroids are considered extremely dangerous by medicine and are in fact outlawed in most "developed" countries. Aside from the (in)famous "roid rage", medicine claims that a large number of chronic conditions (spanning the spectrum from cosmetic to...
  5. fever257

    Androsterone & Sleep

    Hello all, I recently cycled Androsterone (2 drops daily) out of my regimen. I actually ran out but did not refill my supply. I did this to observe effects and see if I had brought my functioning high enough to live without it going forward. Nothing else changed in my regimen at this time...
  6. Mauritio

    Testosterone and androgens increase, estrogen lowers Taurine

    A big part of the taurine in our body comes from our bodies synthesizing it from the amino acids methionine and cysteine via different enzymes. Peat has often talked about the harmfull effects of those two amnino acids in particular. In contrast, he had more good things to say about the amino...
  7. haidut

    Low androgens, not low estrogens, linked to heart disease in aging women

    One of the most pernicious myths medicine created (and has been promoting for the last century) is that menopause is a condition of estrogen "deficiency". Other, similarly pernicious myths are that estradiol is a "female" hormones while testosterone is a "male" hormone. These myths have...
  8. Charlieb91

    Pregnenolone concerns

    I have a bottle of source naturals 10mg pregnenolone in my kitchen cupboard. I want to try it for androgenic/ergogenic effects but I’m concerned it may cause problems as it seems pregnenolone is unpredictable on how people respond hormonally. If I take it and respond bad will discontinuing...
  9. haidut

    Declining DHT in aging linked to cardiovascular disease (CVD)

    Yet another study demonstrating that the "villain of all males around the world" - the dastardly androgen dihydrotestosterone (DHT) - actually is, in all likelihood, beneficial for males, at least when it comes to their cardiovascular health. However, since CVD is one of the risk factors for...
  10. Cameron

    All about increasing 5 alpha reductase in the face and tissues for beard growth and masculine facial structure

    Let’s get a discussion on best ways to truly up regulate androgens and 5-ar (in the skin and tissue) primarily the expression in the face. Beard maxing looks maxing and masculine jaw maxing Results: Testosterone was taken up by both cell types; significant amounts of 5...
  11. haidut

    Fasting decreases androgens, increases aldosterone (and possibly cortisol/estrogens) in women

    I often get criticized that I rely too much on animal studies, so here is a human one that should give the proponents of caloric restriction / fasting a pause. Even a short fast (24-48 hours) resulted in decreased androgen synthesis in women, while increasing aldosterone. In general, fasting...
  12. miquelangeles

    Androgen Biosynthesis in the Stomach

    For the last ~6 months I've been experimenting with pregnenolone in different dosages, frequencies, schedule and routes of administration. There are already numerous threads about it's effects (they are very different depending on all those factors), but I want to mention two things that I...
  13. haidut

    Low testosterone detrimental, TRT beneficial for men with COVID-19

    Within a month of the pandemic start back in early 2020, doctors were already noticing a gender-specific trend in COVID-19 cases. Namely, pre-menopausal women fared much better in terms of COVID-19 disease course compared to post-menopausal women and (adult) men. The ever-corrupt Big Pharma was...
  14. Cameron

    Want a beard? Take androsterone Androsterone has the greatest effect as an androgen in beard growth 20 mgs a day sublingual
  15. Cameron

    T3 increases 5-AR type 1

    “In addition, in Silurana (Xenopus) tropicalis whole body larvae, T3 increases the expression of androgen-related genes, 5α-reductase type 1 (srd5alpha1) and ar (16). Therefore, the present study aimed to investigate whether TH- and sex steroid-related genes are also regulated by T3 in the brain...
  16. Brandin

    Injecting 11ketodht

    Hi could I inject the 11 ketodht in my rat and if so what is the best way?
  17. haidut

    Blocking androgens causes inflammation and prostate disease/cancer

    Yet another study striking directly the incredibly corrupt theory known as the "androgen hypothesis" - i.e. that androgens are the cause of many of the issues aging males experience, especially prostate enlargement (BPH) and/or prostate cancer. For almost a century now, the so-called standard of...
  18. haidut

    Age-related steroid deficiency may be treatable with niacinamide

    The study is actually about eye health, and the effects androgens play in it. However, the findings are not limited to the eyes and are in fact applicable for any other tissue/organ experiencing a decline in steroidogenesis with advancing age, which is basically all of them. As such, I am...
  19. haidut

    Prostate levels of androgens/DHT drastically lower in prostate cancer patients

    Yet another study, which raises serious doubts about the so-called "androgen hypothesis" of prostate cancer (PC). The study found that androgen levels, and especially DHT, are drastically (90%+) lower in PC than in people with benign prostate hyperplasia (BPH). In fact, 1/3 of the PC patients...
  20. Cameron

    Interesting study on testosterone gel topically for increasing terminal facial hair growth in young men. Topical androgens

    Topical androgens like androsterone and dht would likely have similar localized maturation effect of terminal hairs. Hacking beard growth. Male bio hacking. —————————- Objectives: To determine whether the medical prescription of testosterone gel can...
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