optimal

As many of you know, the Wikipedia page has a warning not to take more than 3g daily as it may elevate liver enzymes. I traced the warning to a few studies with high dose niacinamide using 4g - 6g daily for conditions like HIV and arthritis. However, they did not provide an explanation on why...

There was a recent discussion about high dose pregnenolone on the forum and some people sent Peat my comments that high dose pregnenolone can inhibit androgen synthesis. Peat replied that he has not seen such effects, but did not directly speak against the idea. Privately, I got quite a few...

This study is a bit on the wild side in terms of effectiveness claims but it made it through peer reviews so I decided that it is worth posting. It also provides recommendations on optimal doses of these supplements commonly discussed on the forum. Apparently, the optimal dose of vitamin D is...

The steroids androsterone (A) and DHEA are considered not very strong androgens in terms of direct activity on androgenic receptors. DHEA is often cited as having 1/10 of the androgenic effects of testosterone (T) and androsterone as having 1/7 of the androgenic effects. While that has been...

This Danish study further cements the status of the "overweight paradox" as something that will not soon go away or be explained away as a statistical anomaly. While previous studies looked at the survival of people with specific conditions and found the mildly obese to fare best, this study...

Many people on the forum and elsewhere take caffeine for its pro-metabolic and disease-preventing effects. However, caffeine can induce a stress response. This is especially true in people with poor glycogen stores, liver problems, and hypothyroidism in general. This study says that a human dose...

Please keep in mind that by "optimal" these studies consider what is the optimal dose of protein per meal for muscle protein synthesis. The dosage may be different for other people depending on the circumstances. Malnourished, hypothyroid or liver-disease people may need more or less depending...